CRCGN017_MCF10A.WT.HP_24H:F17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dibromoethane 32.98 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 4.78845
MAP7 microtubule-associated protein 7 4.74362
CARMIL1 capping protein regulator and myosin 1 linker 1 4.37615
HBB hemoglobin, beta 4.03675
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 3.99605
ACAA1 acetyl-CoA acyltransferase 1 3.39995
SSBP2 single-stranded DNA binding protein 2 3.0053
HBA1 hemoglobin, alpha 1 2.98198
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.52955
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.5164
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.44245
CEP57 centrosomal protein 57kDa 2.18418
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 2.1818
EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2.173
PAX6 paired box 6 2.08315
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2.04845
TSPAN4 tetraspanin 4 2.04025
TXNL4B thioredoxin-like 4B 2.0348
MOK MOK protein kinase 2.0086

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -5.00885
ARID4B AT rich interactive domain 4B (RBP1-like) -4.76665
DNM1L dynamin 1-like -4.68495
ACOT9 acyl-CoA thioesterase 9 -4.6222
MRPS2 mitochondrial ribosomal protein S2 -4.43555
CCDC86 coiled-coil domain containing 86 -3.86515
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.6814
ARPP19 cAMP-regulated phosphoprotein, 19kDa -3.41112
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.1052
KRT14 keratin 14, type I -2.9607
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.87889
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.8018
RLF rearranged L-myc fusion -2.7464
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.6914
MRPL35 mitochondrial ribosomal protein L35 -2.55995
APOO apolipoprotein O -2.4589
PPP6C protein phosphatase 6, catalytic subunit -2.28367
MSN moesin -2.2731
UBAC1 UBA domain containing 1 -2.16315
GLRX2 glutaredoxin 2 -2.1604
MED21 mediator complex subunit 21 -2.14545
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -2.1119
HCFC2 host cell factor C2 -2.0859
MAP2K4 mitogen-activated protein kinase kinase 4 -2.07867
GPR143 G protein-coupled receptor 143 -2.0562
FKBP1B FK506 binding protein 1B, 12.6 kDa -2.03927
RAB9A RAB9A, member RAS oncogene family -2.03415
CLDND1 claudin domain containing 1 -2.0332
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -2.02385
PLAT plasminogen activator, tissue -2.0056