CRCGN017_MCF10A.WT.HP_24H:F18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dibromoethane 10.99 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

28 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 5.41905
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.7386
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 4.37747
RBM6 RNA binding motif protein 6 4.2417
AGR2 anterior gradient 2 4.1817
SYNE2 spectrin repeat containing, nuclear envelope 2 2.2754
PLS1 plastin 1 2.1986
FSTL1 follistatin-like 1 2.13735
CBX1 chromobox homolog 1 2.09915
SKIC8 SKI8 subunit of superkiller complex 2.09597
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 2.06225
TPD52L2 tumor protein D52-like 2 2.01945

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -8.0696
UFM1 ubiquitin-fold modifier 1 -5.31275
BAG3 BCL2-associated athanogene 3 -4.66355
UBE3C ubiquitin protein ligase E3C -4.29195
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.0069
RNF167 ring finger protein 167 -3.8967
NT5DC2 5'-nucleotidase domain containing 2 -3.72735
NLRP4 NLR family, pyrin domain containing 4 -3.46855
HEATR1 HEAT repeat containing 1 -3.43128
DCK deoxycytidine kinase -3.273
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.8588
ACAA1 acetyl-CoA acyltransferase 1 -2.80198
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.75842
NGRN neugrin, neurite outgrowth associated -2.54145
WASHC4 WASH complex subunit 4 -2.5397
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.1413