CRCGN017_MCF10A.WT.HP_24H:F22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methotrexate 99.37 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

252 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 7.25515
CDPF1 cysteine-rich, DPF motif domain containing 1 4.7683
RGS2 regulator of G-protein signaling 2 4.11455
STAT5B signal transducer and activator of transcription 5B 4.06302
DDB2 damage-specific DNA binding protein 2, 48kDa 3.779
INPP1 inositol polyphosphate-1-phosphatase 3.45705
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.4474
CCDC90B coiled-coil domain containing 90B 3.25925
DDTL D-dopachrome tautomerase-like 3.18015
LYRM1 LYR motif containing 1 3.13065
MEA1 male-enhanced antigen 1 3.10995
HBB hemoglobin, beta 3.03398
IER3 immediate early response 3 2.9582
CCNE2 cyclin E2 2.94252
FDXR ferredoxin reductase 2.8578
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 2.83225
LGALS9C lectin, galactoside-binding, soluble, 9C 2.7847
ABHD11 abhydrolase domain containing 11 2.7729
BAX BCL2-associated X protein 2.76655
APOL6 apolipoprotein L, 6 2.75325
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa 2.73895
LSR lipolysis stimulated lipoprotein receptor 2.6901
SESN1 sestrin 1 2.68045
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.6369
MED15 mediator complex subunit 15 2.6054
IFI35 interferon-induced protein 35 2.58175
STAP2 signal transducing adaptor family member 2 2.54835
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 2.5387
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.53505
STAT5A signal transducer and activator of transcription 5A 2.51875
EPHA2 EPH receptor A2 2.51395
LRP10 low density lipoprotein receptor-related protein 10 2.4865
TTLL1 tubulin tyrosine ligase-like family member 1 2.4824
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 2.4779
BCL7C B-cell CLL/lymphoma 7C 2.4634
THAP7 THAP domain containing 7 2.4502
FOS FBJ murine osteosarcoma viral oncogene homolog 2.4393
CDC45 cell division cycle 45 2.41885
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.4099
HMGXB4 HMG box domain containing 4 2.38573
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 2.37095
MPDU1 mannose-P-dolichol utilization defect 1 2.3336
CIRBP cold inducible RNA binding protein 2.32827
EPPK1 epiplakin 1 2.3271
RBM34 RNA binding motif protein 34 2.31268
DGCR6L DiGeorge syndrome critical region gene 6-like 2.299
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.29445
PGAP6 post-GPI attachment to proteins 6 2.28
LOC102724023 ES1 protein homolog, mitochondrial 2.2693
GMIP GEM interacting protein 2.2687
PSMC3IP PSMC3 interacting protein 2.25103
NAGK N-acetylglucosamine kinase 2.24025
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.2304
ATF3 activating transcription factor 3 2.20335
AMDHD2 amidohydrolase domain containing 2 2.19895
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.19565
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa 2.18883
USP18 ubiquitin specific peptidase 18 2.1794
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.17625
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 2.16695
CAMK1 calcium/calmodulin-dependent protein kinase I 2.1629
MYL5 myosin, light chain 5, regulatory 2.1446
ENO2 enolase 2 (gamma, neuronal) 2.1445
PCNA proliferating cell nuclear antigen 2.13605
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 2.13255
YPEL1 yippee-like 1 (Drosophila) 2.13195
DSN1 DSN1, MIS12 kinetochore complex component 2.1231
TLE5 TLE family member 5, transcriptional modulator 2.12065
FHIP2B FHF complex subunit HOOK interacting protein 2B 2.1181
LMF2 lipase maturation factor 2 2.11518
SCAND1 SCAN domain containing 1 2.11495
NONO non-POU domain containing, octamer-binding 2.10972
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae) 2.10898
PPCS phosphopantothenoylcysteine synthetase 2.10895
LOXL1 lysyl oxidase-like 1 2.1064
DUSP3 dual specificity phosphatase 3 2.10142
BTG2 BTG family, member 2 2.09917
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) 2.09795
RFXANK regulatory factor X-associated ankyrin-containing protein 2.0966
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.0879
SH2D1A SH2 domain containing 1A 2.0768
SPATA20 spermatogenesis associated 20 2.07335
JMJD7 jumonji domain containing 7 2.06795
SMCO4 single-pass membrane protein with coiled-coil domains 4 2.066
LPAR2 lysophosphatidic acid receptor 2 2.06512
PNKP polynucleotide kinase 3'-phosphatase 2.0592
PAX6 paired box 6 2.05815
PLEKHO1 pleckstrin homology domain containing, family O member 1 2.05205
DONSON downstream neighbor of SON 2.0499
GALE UDP-galactose-4-epimerase 2.0433
SV2A synaptic vesicle glycoprotein 2A 2.04055
SMAD3 SMAD family member 3 2.03976
COCH cochlin 2.03495
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.0335
CCNE1 cyclin E1 2.03305
DHFR dihydrofolate reductase 2.0329
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 2.0308
ABHD14A abhydrolase domain containing 14A 2.02455
THTPA thiamine triphosphatase 2.024
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.01955
CPT1B carnitine palmitoyltransferase 1B (muscle) 2.01945
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.01865
LSP1 lymphocyte-specific protein 1 2.015
FCHSD2 FCH and double SH3 domains 2 2.00155

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -10.0
PLK1 polo-like kinase 1 -9.3609
KIF20A kinesin family member 20A -7.8231
UBE2C ubiquitin-conjugating enzyme E2C -7.24665
PSRC1 proline/serine-rich coiled-coil 1 -6.42115
CCNB2 cyclin B2 -5.40275
TOP2A topoisomerase (DNA) II alpha 170kDa -5.1543
KIF14 kinesin family member 14 -4.75285
CCNB1 cyclin B1 -4.5959
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.45085
TLCD3A TLC domain containing 3A -4.27925
TXNDC9 thioredoxin domain containing 9 -4.14733
AURKA aurora kinase A -4.10987
CDC25B cell division cycle 25B -3.9556
MT2A metallothionein 2A -3.938
LBR lamin B receptor -3.9293
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -3.8896
NEK2 NIMA-related kinase 2 -3.8505
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.75273
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -3.72795
CENPE centromere protein E, 312kDa -3.4465
TXNRD1 thioredoxin reductase 1 -3.4381
FASTKD5 FAST kinase domains 5 -3.33845
WASHC4 WASH complex subunit 4 -3.31458
KIF4A kinesin family member 4A -3.30695
MT1X metallothionein 1X -3.30565
ARID4B AT rich interactive domain 4B (RBP1-like) -3.1798
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.14995
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.14385
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.13995
HJURP Holliday junction recognition protein -3.07415
NCAPD2 non-SMC condensin I complex, subunit D2 -3.0683
RACGAP1 Rac GTPase activating protein 1 -3.0373
KIF18A kinesin family member 18A -3.0359
DEPDC1 DEP domain containing 1 -3.01825
TWNK twinkle mtDNA helicase -3.00535
HMGB3 high mobility group box 3 -2.9902
YY1AP1 YY1 associated protein 1 -2.9871
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.9738
WASF3 WAS protein family, member 3 -2.966
KIF11 kinesin family member 11 -2.9589
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 -2.93628
KIF23 kinesin family member 23 -2.92945
CDC25C cell division cycle 25C -2.9293
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.8832
CDCA3 cell division cycle associated 3 -2.83685
EIF3B eukaryotic translation initiation factor 3, subunit B -2.83412
CENPA centromere protein A -2.8295
HSPA1A heat shock 70kDa protein 1A -2.82825
ACAA1 acetyl-CoA acyltransferase 1 -2.81635
MTERF3 mitochondrial transcription termination factor 3 -2.7963
CCNA2 cyclin A2 -2.78825
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.77028
CUL4A cullin 4A -2.6839
PIBF1 progesterone immunomodulatory binding factor 1 -2.63075
ZNF516 zinc finger protein 516 -2.62505
TTK TTK protein kinase -2.5798
AGO2 argonaute RISC catalytic component 2 -2.57345
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -2.56625
UNC50 unc-50 homolog (C. elegans) -2.5654
PIMREG PICALM interacting mitotic regulator -2.55955
KIN Kin17 DNA and RNA binding protein -2.557
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -2.5515
ZNF263 zinc finger protein 263 -2.54845
NOP16 NOP16 nucleolar protein -2.548
XPO6 exportin 6 -2.54142
USP6NL USP6 N-terminal like -2.5235
ANKRD28 ankyrin repeat domain 28 -2.51865
KIAA0232 KIAA0232 -2.5142
TASOR transcription activation suppressor -2.4937
TATDN2 TatD DNase domain containing 2 -2.478
PUS1 pseudouridylate synthase 1 -2.4719
PBK PDZ binding kinase -2.4567
PRC1 protein regulator of cytokinesis 1 -2.4447
NDC80 NDC80 kinetochore complex component -2.43755
MEMO1 mediator of cell motility 1 -2.4283
TPST1 tyrosylprotein sulfotransferase 1 -2.4272
CKS2 CDC28 protein kinase regulatory subunit 2 -2.4262
NUSAP1 nucleolar and spindle associated protein 1 -2.42018
CKAP2 cytoskeleton associated protein 2 -2.42015
ANKRD10 ankyrin repeat domain 10 -2.41505
BIRC5 baculoviral IAP repeat containing 5 -2.41167
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.40637
CDCA8 cell division cycle associated 8 -2.4022
GPSM2 G-protein signaling modulator 2 -2.3904
TFB2M transcription factor B2, mitochondrial -2.3722
BORA bora, aurora kinase A activator -2.36745
LARP4 La ribonucleoprotein domain family, member 4 -2.35848
TOP2B topoisomerase (DNA) II beta 180kDa -2.3544
REV1 REV1, polymerase (DNA directed) -2.34565
TASOR2 transcription activation suppressor family member 2 -2.34465
MED17 mediator complex subunit 17 -2.3439
SAP30 Sin3A-associated protein, 30kDa -2.33845
CKS1B CDC28 protein kinase regulatory subunit 1B -2.3354
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A -2.3347
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.32345
RUVBL1 RuvB-like AAA ATPase 1 -2.32255
EIF5B eukaryotic translation initiation factor 5B -2.31679
RNF4 ring finger protein 4 -2.3039
ZBTB11 zinc finger and BTB domain containing 11 -2.28135
COA7 cytochrome c oxidase assembly factor 7 (putative) -2.27875
DPH2 DPH2 homolog (S. cerevisiae) -2.2651
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.2643
ELANE elastase, neutrophil expressed -2.25855
MAEA macrophage erythroblast attacher -2.2562
STMN1 stathmin 1 -2.2542
PARPBP PARP1 binding protein -2.25235
UBP1 upstream binding protein 1 (LBP-1a) -2.24305
WDR3 WD repeat domain 3 -2.2349
HOXA11 homeobox A11 -2.22578
FAM53C family with sequence similarity 53, member C -2.2042
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.2027
TACC3 transforming, acidic coiled-coil containing protein 3 -2.2025
DCAF6 DDB1 and CUL4 associated factor 6 -2.19745
ANAPC1 anaphase promoting complex subunit 1 -2.19675
FNBP4 formin binding protein 4 -2.17475
PNRC2 proline-rich nuclear receptor coactivator 2 -2.16565
METTL8 methyltransferase like 8 -2.13715
INTS15 integrator complex subunit 15 -2.13683
NUP93 nucleoporin 93kDa -2.13545
FBXO5 F-box protein 5 -2.134
BBS10 Bardet-Biedl syndrome 10 -2.11965
FAM168B family with sequence similarity 168, member B -2.11335
ZFTA zinc finger translocation associated -2.107
PALS2 protein associated with LIN7 2, MAGUK p55 family member -2.10525
TPX2 TPX2, microtubule-associated -2.09625
CEP55 centrosomal protein 55kDa -2.0947
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -2.08138
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.07875
ARHGAP17 Rho GTPase activating protein 17 -2.07715
TULP4 tubby like protein 4 -2.076
ARL5A ADP-ribosylation factor-like 5A -2.0656
CAB39 calcium binding protein 39 -2.0598
RPP38 ribonuclease P/MRP 38kDa subunit -2.05255
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.0509
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -2.05055
INSIG1 insulin induced gene 1 -2.0505
MKI67 marker of proliferation Ki-67 -2.04376
SMNDC1 survival motor neuron domain containing 1 -2.03805
TKT transketolase -2.03105
TFCP2 transcription factor CP2 -2.02513
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.01935
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -2.01585
INTS6 integrator complex subunit 6 -2.01463
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -2.01305
TCF12 transcription factor 12 -2.0075
RAB23 RAB23, member RAS oncogene family -2.0016
PTPN20 protein tyrosine phosphatase, non-receptor type 20 -2.00115