CRCGN017_MCF10A.WT.HP_24H:F23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methotrexate 33.12 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

228 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 5.17625
RGS2 regulator of G-protein signaling 2 4.9313
PLSCR1 phospholipid scramblase 1 4.89218
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.7832
DDB2 damage-specific DNA binding protein 2, 48kDa 4.21105
CDPF1 cysteine-rich, DPF motif domain containing 1 4.13185
HBB hemoglobin, beta 3.58608
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.48065
INPP1 inositol polyphosphate-1-phosphatase 3.45035
PECR peroxisomal trans-2-enoyl-CoA reductase 3.358
FDXR ferredoxin reductase 3.16645
LRP10 low density lipoprotein receptor-related protein 10 3.12185
IER3 immediate early response 3 3.07905
ACAA1 acetyl-CoA acyltransferase 1 3.07698
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.0174
FHIP2B FHF complex subunit HOOK interacting protein 2B 2.98855
NUCB2 nucleobindin 2 2.9723
EVL Enah/Vasp-like 2.9723
LOXL1 lysyl oxidase-like 1 2.89005
IRF7 interferon regulatory factor 7 2.86395
EPHA2 EPH receptor A2 2.7019
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.6986
STN1 STN1 subunit of CST complex 2.69715
LSR lipolysis stimulated lipoprotein receptor 2.66875
MCM5 minichromosome maintenance complex component 5 2.65522
CCND3 cyclin D3 2.6279
IGFLR1 IGF-like family receptor 1 2.6069
GALE UDP-galactose-4-epimerase 2.59115
JMJD7 jumonji domain containing 7 2.5563
CDC45 cell division cycle 45 2.5318
SKIC2 SKI2 subunit of superkiller complex 2.52645
BAX BCL2-associated X protein 2.5061
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 2.5
TYR tyrosinase 2.4974
CNRIP1 cannabinoid receptor interacting protein 1 2.49565
KRT16 keratin 16, type I 2.4765
BGN biglycan 2.43403
IFITM1 interferon induced transmembrane protein 1 2.41305
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.41225
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 2.4043
SLC46A3 solute carrier family 46, member 3 2.4038
FOS FBJ murine osteosarcoma viral oncogene homolog 2.36745
RBKS ribokinase 2.367
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.3606
CCS copper chaperone for superoxide dismutase 2.3605
CHMP6 charged multivesicular body protein 6 2.31825
COL18A1 collagen, type XVIII, alpha 1 2.30142
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 2.29645
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.29535
MGMT O-6-methylguanine-DNA methyltransferase 2.28925
BIN2 bridging integrator 2 2.27345
CCP110 centriolar coiled coil protein 110kDa 2.26785
KRT6A keratin 6A, type II 2.26683
FCHSD2 FCH and double SH3 domains 2 2.2657
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.22835
FASN fatty acid synthase 2.22403
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.223
KRT6B keratin 6B, type II 2.21705
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2.1926
FGGY FGGY carbohydrate kinase domain containing 2.1895
LCAT lecithin-cholesterol acyltransferase 2.17795
SUGCT succinyl-CoA:glutarate-CoA transferase 2.1773
AEBP1 AE binding protein 1 2.16865
HBA1 hemoglobin, alpha 1 2.16558
CIDEB cell death-inducing DFFA-like effector b 2.16085
PNKP polynucleotide kinase 3'-phosphatase 2.14775
CYB5R3 cytochrome b5 reductase 3 2.1402
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.11165
RAP1GAP RAP1 GTPase activating protein 2.10705
ETHE1 ethylmalonic encephalopathy 1 2.0876
TRAPPC6A trafficking protein particle complex 6A 2.08085
IFI27 interferon, alpha-inducible protein 27 2.0775
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 2.07505
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 2.05855
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.03898
CHKB choline kinase beta 2.0374
AMDHD2 amidohydrolase domain containing 2 2.03635
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.02685
TTLL1 tubulin tyrosine ligase-like family member 1 2.02595
SLC45A2 solute carrier family 45, member 2 2.02042
ITM2B integral membrane protein 2B 2.01925
MTG1 mitochondrial ribosome-associated GTPase 1 2.01915
MED15 mediator complex subunit 15 2.0124
IRF9 interferon regulatory factor 9 2.00935
TBX19 T-box 19 2.0083

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -10.0
PLK1 polo-like kinase 1 -8.2723
KIF20A kinesin family member 20A -6.97665
UBE2C ubiquitin-conjugating enzyme E2C -6.8261
EXOSC4 exosome component 4 -6.79313
CCNB1 cyclin B1 -6.75715
LBR lamin B receptor -6.398
TOP2A topoisomerase (DNA) II alpha 170kDa -5.76702
PSRC1 proline/serine-rich coiled-coil 1 -5.10195
HAT1 histone acetyltransferase 1 -5.09405
AURKA aurora kinase A -4.39042
CCNB2 cyclin B2 -4.3421
CIAPIN1 cytokine induced apoptosis inhibitor 1 -4.2282
HMMR hyaluronan-mediated motility receptor (RHAMM) -4.17902
KIF4A kinesin family member 4A -4.1672
HEATR1 HEAT repeat containing 1 -4.14808
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -4.1337
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.07125
KIF14 kinesin family member 14 -3.8327
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.7241
CDC25B cell division cycle 25B -3.71765
ARID4B AT rich interactive domain 4B (RBP1-like) -3.70425
NT5DC2 5'-nucleotidase domain containing 2 -3.58215
NCAPD2 non-SMC condensin I complex, subunit D2 -3.4888
STXBP2 syntaxin binding protein 2 -3.4731
NEK2 NIMA-related kinase 2 -3.31403
RBM12B RNA binding motif protein 12B -3.26815
DEPDC1 DEP domain containing 1 -3.20955
CDCA8 cell division cycle associated 8 -3.15825
CCNA2 cyclin A2 -3.14395
TXNRD1 thioredoxin reductase 1 -3.02985
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -3.0277
WASF3 WAS protein family, member 3 -3.0146
TMEM50A transmembrane protein 50A -2.9287
TPX2 TPX2, microtubule-associated -2.92585
WDR3 WD repeat domain 3 -2.8843
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.82055
CENPA centromere protein A -2.80273
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.78625
AGO2 argonaute RISC catalytic component 2 -2.78565
CENPE centromere protein E, 312kDa -2.7793
MTERF3 mitochondrial transcription termination factor 3 -2.77245
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.75445
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough -2.7479
CUL4A cullin 4A -2.7056
TACC3 transforming, acidic coiled-coil containing protein 3 -2.6958
EMC8 ER membrane protein complex subunit 8 -2.6822
CDC25C cell division cycle 25C -2.63198
BIRC5 baculoviral IAP repeat containing 5 -2.61953
GARRE1 granule associated Rac and RHOG effector 1 -2.59325
METTL13 methyltransferase like 13 -2.5837
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -2.56905
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa -2.56765
TLCD3A TLC domain containing 3A -2.5589
TROAP trophinin associated protein -2.5576
FASTKD1 FAST kinase domains 1 -2.5566
PTTG1 pituitary tumor-transforming 1 -2.55365
NOP16 NOP16 nucleolar protein -2.54597
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.51565
PCF11 PCF11 cleavage and polyadenylation factor subunit -2.5144
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.5059
KIF11 kinesin family member 11 -2.49465
HJURP Holliday junction recognition protein -2.4916
INTS6 integrator complex subunit 6 -2.4709
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 -2.4594
TASOR transcription activation suppressor -2.45258
NUSAP1 nucleolar and spindle associated protein 1 -2.44282
HOXA5 homeobox A5 -2.4341
TOMM34 translocase of outer mitochondrial membrane 34 -2.43265
CDCA3 cell division cycle associated 3 -2.4277
KIF18A kinesin family member 18A -2.41515
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.4052
ZNF250 zinc finger protein 250 -2.39485
TRIM27 tripartite motif containing 27 -2.39397
AK6 adenylate kinase 6 -2.39205
SAFB scaffold attachment factor B -2.3812
CREG1 cellular repressor of E1A-stimulated genes 1 -2.3797
SSB Sjogren syndrome antigen B (autoantigen La) -2.37585
MTHFSD methenyltetrahydrofolate synthetase domain containing -2.36205
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -2.35345
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) -2.35185
FASTKD5 FAST kinase domains 5 -2.3351
METTL8 methyltransferase like 8 -2.3266
ZNF143 zinc finger protein 143 -2.31415
ECT2 epithelial cell transforming 2 -2.29575
TCERG1 transcription elongation regulator 1 -2.29545
CNOT1 CCR4-NOT transcription complex, subunit 1 -2.29475
MMP3 matrix metallopeptidase 3 -2.28775
UBE2S ubiquitin-conjugating enzyme E2S -2.2824
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -2.28075
BORA bora, aurora kinase A activator -2.2747
FBXO28 F-box protein 28 -2.27375
PIMREG PICALM interacting mitotic regulator -2.26865
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.26586
NOLC1 nucleolar and coiled-body phosphoprotein 1 -2.26242
NCOA6 nuclear receptor coactivator 6 -2.2388
LARP4 La ribonucleoprotein domain family, member 4 -2.23602
MAT2A methionine adenosyltransferase II, alpha -2.23088
PARG poly (ADP-ribose) glycohydrolase -2.22765
MPZL1 myelin protein zero-like 1 -2.22693
CARM1 coactivator-associated arginine methyltransferase 1 -2.22685
TFDP1 transcription factor Dp-1 -2.21875
CDKN3 cyclin-dependent kinase inhibitor 3 -2.21315
PPP1R10 protein phosphatase 1, regulatory subunit 10 -2.20675
NVL nuclear VCP-like -2.2058
HEATR3 HEAT repeat containing 3 -2.20155
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -2.1853
ATF6 activating transcription factor 6 -2.17913
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough -2.1714
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.1559
CENPF centromere protein F, 350/400kDa -2.1522
CEP55 centrosomal protein 55kDa -2.1493
MKI67 marker of proliferation Ki-67 -2.14878
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 -2.14675
AP1AR adaptor-related protein complex 1 associated regulatory protein -2.13965
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.10535
PSME3IP1 proteasome activator subunit 3 interacting protein 1 -2.104
ZNF623 zinc finger protein 623 -2.09505
POGK pogo transposable element with KRAB domain -2.0839
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 -2.07955
HOXA11 homeobox A11 -2.07868
SPC25 SPC25, NDC80 kinetochore complex component -2.078
KIF15 kinesin family member 15 -2.0778
SPDL1 spindle apparatus coiled-coil protein 1 -2.0699
PUS1 pseudouridylate synthase 1 -2.06615
HOXA10 homeobox A10 -2.06395
MRPL37 mitochondrial ribosomal protein L37 -2.05875
CAB39 calcium binding protein 39 -2.0574
PLAGL2 pleiomorphic adenoma gene-like 2 -2.05253
RACGAP1 Rac GTPase activating protein 1 -2.0521
INSIG1 insulin induced gene 1 -2.05045
MAP7D3 MAP7 domain containing 3 -2.03815
GSPT1 G1 to S phase transition 1 -2.03187
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.03045
BASP1 brain abundant, membrane attached signal protein 1 -2.0173
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa -2.016
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.016
PRC1 protein regulator of cytokinesis 1 -2.01305
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 -2.0119
IDE insulin-degrading enzyme -2.00785
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha -2.00765
MAPRE1 microtubule-associated protein, RP/EB family, member 1 -2.00493
ZFC3H1 zinc finger, C3H1-type containing -2.0035