| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | methotrexate 11.04 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome) |
| Similar Terms | |
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295 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 10.0 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 5.9297 |
| SPAG4 | sperm associated antigen 4 | 5.24555 |
| ZW10 | zw10 kinetochore protein | 5.0789 |
| WIF1 | WNT inhibitory factor 1 | 5.0 |
| AGR2 | anterior gradient 2 | 4.72945 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 4.66275 |
| COMP | cartilage oligomeric matrix protein | 4.6378 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 4.5943 |
| FKBP14 | FK506 binding protein 14, 22 kDa | 4.5844 |
| RGS2 | regulator of G-protein signaling 2 | 4.58095 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | 4.36575 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 4.07635 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.92567 |
| FDXR | ferredoxin reductase | 3.85265 |
| COL11A1 | collagen, type XI, alpha 1 | 3.55017 |
| EPHA2 | EPH receptor A2 | 3.46375 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 3.1485 |
| ACAA1 | acetyl-CoA acyltransferase 1 | 3.1257 |
| GSAP | gamma-secretase activating protein | 3.10715 |
| ZMAT3 | zinc finger, matrin-type 3 | 2.98425 |
| JMJD7 | jumonji domain containing 7 | 2.9574 |
| INPP1 | inositol polyphosphate-1-phosphatase | 2.9113 |
| ALDH4A1 | aldehyde dehydrogenase 4 family, member A1 | 2.89962 |
| AMDHD2 | amidohydrolase domain containing 2 | 2.88885 |
| HBB | hemoglobin, beta | 2.82467 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.81845 |
| TNFRSF14 | tumor necrosis factor receptor superfamily, member 14 | 2.8116 |
| IRAK4 | interleukin-1 receptor-associated kinase 4 | 2.785 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase | 2.768 |
| IER3 | immediate early response 3 | 2.76405 |
| RECQL | RecQ helicase-like | 2.70659 |
| TRIM22 | tripartite motif containing 22 | 2.70415 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 2.70315 |
| LOXL1 | lysyl oxidase-like 1 | 2.67425 |
| APOBEC3C | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C | 2.6258 |
| HAGH | hydroxyacylglutathione hydrolase | 2.61455 |
| CYB5R1 | cytochrome b5 reductase 1 | 2.60505 |
| SPSB3 | splA/ryanodine receptor domain and SOCS box containing 3 | 2.60427 |
| STN1 | STN1 subunit of CST complex | 2.59155 |
| FASN | fatty acid synthase | 2.58654 |
| DTX2 | deltex 2, E3 ubiquitin ligase | 2.57095 |
| NTM | neurotrimin | 2.5697 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 2.56575 |
| BAX | BCL2-associated X protein | 2.56507 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 2.5534 |
| SFI1 | Sfi1 homolog, spindle assembly associated (yeast) | 2.54945 |
| NAGK | N-acetylglucosamine kinase | 2.5463 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.49345 |
| BIRC7 | baculoviral IAP repeat containing 7 | 2.4772 |
| BCL7B | B-cell CLL/lymphoma 7B | 2.47295 |
| CEP131 | centrosomal protein 131kDa | 2.44865 |
| TBC1D8B | TBC1 domain family, member 8B (with GRAM domain) | 2.4376 |
| CRELD1 | cysteine-rich with EGF-like domains 1 | 2.42225 |
| SIGLEC15 | sialic acid binding Ig-like lectin 15 | 2.416 |
| GPR87 | G protein-coupled receptor 87 | 2.4117 |
| PICK1 | protein interacting with PRKCA 1 | 2.3987 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 2.39233 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 2.38795 |
| HPS4 | Hermansky-Pudlak syndrome 4 | 2.3712 |
| CLN8 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | 2.36905 |
| MGMT | O-6-methylguanine-DNA methyltransferase | 2.35125 |
| S1PR4 | sphingosine-1-phosphate receptor 4 | 2.351 |
| RHCG | Rh family, C glycoprotein | 2.35095 |
| EPS8L2 | EPS8-like 2 | 2.3449 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 2.3397 |
| PGAP6 | post-GPI attachment to proteins 6 | 2.3368 |
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 | 2.3281 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | 2.3133 |
| AEN | apoptosis enhancing nuclease | 2.31295 |
| ZNF76 | zinc finger protein 76 | 2.3028 |
| OR7A5 | olfactory receptor, family 7, subfamily A, member 5 | 2.30245 |
| ACADS | acyl-CoA dehydrogenase, C-2 to C-3 short chain | 2.29735 |
| TSPAN6 | tetraspanin 6 | 2.2911 |
| PLAU | plasminogen activator, urokinase | 2.27032 |
| PLCH2 | phospholipase C, eta 2 | 2.26765 |
| GCHFR | GTP cyclohydrolase I feedback regulator | 2.26625 |
| PNKP | polynucleotide kinase 3'-phosphatase | 2.26305 |
| COXFA4L2 | cytochrome c oxidase hypoxia associated subunit FA4L2 | 2.2614 |
| MICALL2 | MICAL-like 2 | 2.26125 |
| CCN2 | cellular communication network factor 2 | 2.25055 |
| GALT | galactose-1-phosphate uridylyltransferase | 2.2461 |
| CHRNG | cholinergic receptor, nicotinic, gamma (muscle) | 2.2458 |
| SLC25A22 | solute carrier family 25 (mitochondrial carrier: glutamate), member 22 | 2.23658 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 2.2354 |
| FHIP2B | FHF complex subunit HOOK interacting protein 2B | 2.2231 |
| SPATA20 | spermatogenesis associated 20 | 2.22085 |
| SYTL2 | synaptotagmin-like 2 | 2.2197 |
| PGLYRP1 | peptidoglycan recognition protein 1 | 2.2153 |
| KLHL36 | kelch-like family member 36 | 2.19745 |
| ITM2B | integral membrane protein 2B | 2.1973 |
| CIDEB | cell death-inducing DFFA-like effector b | 2.1959 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2.1957 |
| UBA7 | ubiquitin-like modifier activating enzyme 7 | 2.1956 |
| STK38 | serine/threonine kinase 38 | 2.19285 |
| KRT13 | keratin 13, type I | 2.18545 |
| ULBP2 | UL16 binding protein 2 | 2.1742 |
| DSE | dermatan sulfate epimerase | 2.16235 |
| DUSP14 | dual specificity phosphatase 14 | 2.1526 |
| ETHE1 | ethylmalonic encephalopathy 1 | 2.14265 |
| ACAP1 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 | 2.1391 |
| RIOK3 | RIO kinase 3 | 2.13278 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 2.12657 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | 2.12075 |
| INKA2 | inka box actin regulator 2 | 2.1205 |
| CADM1 | cell adhesion molecule 1 | 2.11918 |
| DAPL1 | death associated protein-like 1 | 2.1184 |
| POMGNT1 | protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | 2.1125 |
| CIRBP | cold inducible RNA binding protein | 2.11243 |
| FCHSD2 | FCH and double SH3 domains 2 | 2.1081 |
| MAB21L4 | mab-21 like 4 | 2.1074 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 2.0981 |
| HCFC2 | host cell factor C2 | 2.0941 |
| FHL2 | four and a half LIM domains 2 | 2.0907 |
| DRAM1 | DNA-damage regulated autophagy modulator 1 | 2.08505 |
| SCCPDH | saccharopine dehydrogenase (putative) | 2.08498 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 2.0781 |
| STAP2 | signal transducing adaptor family member 2 | 2.07625 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 2.06395 |
| RING1 | ring finger protein 1 | 2.06165 |
| PIGQ | phosphatidylinositol glycan anchor biosynthesis, class Q | 2.0562 |
| MMP13 | matrix metallopeptidase 13 | 2.0535 |
| CENPM | centromere protein M | 2.03995 |
| SLC25A1 | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 | 2.03925 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 2.0392 |
| SLC45A2 | solute carrier family 45, member 2 | 2.0349 |
| POMC | proopiomelanocortin | 2.03395 |
| BTN2A2 | butyrophilin, subfamily 2, member A2 | 2.02553 |
| MEGF6 | multiple EGF-like-domains 6 | 2.0251 |
| RAD51AP1 | RAD51 associated protein 1 | 2.02405 |
| GLTP | glycolipid transfer protein | 2.0174 |
| PLA2G15 | phospholipase A2, group XV | 2.0162 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 2.0105 |
| TMEM134 | transmembrane protein 134 | 2.00525 |
| TTC12 | tetratricopeptide repeat domain 12 | 2.00495 |
| SLC16A8 | solute carrier family 16 (monocarboxylate transporter), member 8 | 2.0032 |
| AEBP1 | AE binding protein 1 | 2.00285 |
| ABHD11 | abhydrolase domain containing 11 | 2.00245 |
| TRAK2 | trafficking protein, kinesin binding 2 | 2.00195 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDC20 | cell division cycle 20 | -10.0 |
| PLK1 | polo-like kinase 1 | -8.7584 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -7.4785 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -7.4448 |
| KIF20A | kinesin family member 20A | -6.7109 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -5.31582 |
| HMG20B | high mobility group 20B | -5.1658 |
| CCNB2 | cyclin B2 | -4.96865 |
| AURKA | aurora kinase A | -4.8077 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -4.66275 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -4.2439 |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) | -4.1586 |
| CDC25B | cell division cycle 25B | -4.15825 |
| MT2A | metallothionein 2A | -4.14545 |
| CCNB1 | cyclin B1 | -4.0762 |
| KIF14 | kinesin family member 14 | -3.9481 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | -3.86188 |
| MT1X | metallothionein 1X | -3.77533 |
| MTERF3 | mitochondrial transcription termination factor 3 | -3.6043 |
| CAB39 | calcium binding protein 39 | -3.57275 |
| PHOSPHO2-KLHL23 | PHOSPHO2-KLHL23 readthrough | -3.53625 |
| KIF4A | kinesin family member 4A | -3.52465 |
| DEPDC1 | DEP domain containing 1 | -3.4859 |
| LBR | lamin B receptor | -3.4707 |
| CDCA8 | cell division cycle associated 8 | -3.32565 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -3.31502 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -3.295 |
| PIMREG | PICALM interacting mitotic regulator | -3.227 |
| INTS8 | integrator complex subunit 8 | -3.16655 |
| FKBP4 | FK506 binding protein 4, 59kDa | -3.16213 |
| WASF3 | WAS protein family, member 3 | -3.1043 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -3.074 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -3.06765 |
| CDK1 | cyclin-dependent kinase 1 | -3.06548 |
| NEK2 | NIMA-related kinase 2 | -3.04205 |
| CENPA | centromere protein A | -3.00345 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -2.98405 |
| PTTG1 | pituitary tumor-transforming 1 | -2.95745 |
| AGO2 | argonaute RISC catalytic component 2 | -2.9106 |
| RUVBL1 | RuvB-like AAA ATPase 1 | -2.9105 |
| TPX2 | TPX2, microtubule-associated | -2.9042 |
| CCNA2 | cyclin A2 | -2.85085 |
| TROAP | trophinin associated protein | -2.84545 |
| FASTKD5 | FAST kinase domains 5 | -2.84435 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.81205 |
| HSPA1A | heat shock 70kDa protein 1A | -2.78615 |
| CDCA3 | cell division cycle associated 3 | -2.78115 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | -2.78005 |
| WDR3 | WD repeat domain 3 | -2.7758 |
| HJURP | Holliday junction recognition protein | -2.7725 |
| EBNA1BP2 | EBNA1 binding protein 2 | -2.76245 |
| RBM6 | RNA binding motif protein 6 | -2.7613 |
| CDC25C | cell division cycle 25C | -2.70377 |
| RNF4 | ring finger protein 4 | -2.70285 |
| HMGB3 | high mobility group box 3 | -2.68745 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -2.66905 |
| ANKRD27 | ankyrin repeat domain 27 (VPS9 domain) | -2.6341 |
| MRPS30 | mitochondrial ribosomal protein S30 | -2.60768 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -2.60395 |
| EMC8 | ER membrane protein complex subunit 8 | -2.5996 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -2.57587 |
| CD81 | CD81 molecule | -2.5617 |
| SAFB | scaffold attachment factor B | -2.55982 |
| TXNRD1 | thioredoxin reductase 1 | -2.5555 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -2.54408 |
| NOP16 | NOP16 nucleolar protein | -2.54205 |
| DARS2 | aspartyl-tRNA synthetase 2, mitochondrial | -2.53995 |
| TLCD3A | TLC domain containing 3A | -2.5376 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -2.52395 |
| AHCTF1 | AT hook containing transcription factor 1 | -2.5127 |
| CUL4A | cullin 4A | -2.44847 |
| HOXA5 | homeobox A5 | -2.4146 |
| RPIA | ribose 5-phosphate isomerase A | -2.4036 |
| DPH2 | DPH2 homolog (S. cerevisiae) | -2.4025 |
| MT1H | metallothionein 1H | -2.39705 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -2.39242 |
| HEATR1 | HEAT repeat containing 1 | -2.38637 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -2.38042 |
| NRF1 | nuclear respiratory factor 1 | -2.3732 |
| TWNK | twinkle mtDNA helicase | -2.35965 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | -2.353 |
| DNAAF2 | dynein, axonemal, assembly factor 2 | -2.35285 |
| SDAD1 | SDA1 domain containing 1 | -2.3493 |
| PODXL | podocalyxin-like | -2.34045 |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | -2.3332 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -2.3279 |
| MAGEA2B | melanoma antigen family A2B | -2.32115 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -2.32075 |
| NUP93 | nucleoporin 93kDa | -2.30985 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -2.3097 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -2.3072 |
| MT1E | metallothionein 1E | -2.30035 |
| SNRPB2 | small nuclear ribonucleoprotein polypeptide B | -2.3001 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | -2.2976 |
| DCP1A | decapping mRNA 1A | -2.2934 |
| TCERG1 | transcription elongation regulator 1 | -2.26685 |
| RSBN1 | round spermatid basic protein 1 | -2.2486 |
| SETBP1 | SET binding protein 1 | -2.2462 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -2.23395 |
| GTF2E1 | general transcription factor IIE, polypeptide 1, alpha 56kDa | -2.23045 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | -2.2244 |
| TSC22D1 | TSC22 domain family, member 1 | -2.2219 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | -2.21873 |
| LARS2 | leucyl-tRNA synthetase 2, mitochondrial | -2.21622 |
| NES | nestin | -2.2094 |
| CHRDL1 | chordin-like 1 | -2.20305 |
| LPL | lipoprotein lipase | -2.197 |
| KIF18A | kinesin family member 18A | -2.19665 |
| PRC1 | protein regulator of cytokinesis 1 | -2.1941 |
| RAB20 | RAB20, member RAS oncogene family | -2.18635 |
| PUF60 | poly-U binding splicing factor 60KDa | -2.1752 |
| DKC1 | dyskeratosis congenita 1, dyskerin | -2.17438 |
| CCNF | cyclin F | -2.16535 |
| MT1F | metallothionein 1F | -2.16328 |
| BMS1 | BMS1 ribosome biogenesis factor | -2.1528 |
| MT1G | metallothionein 1G | -2.1506 |
| NDC80 | NDC80 kinetochore complex component | -2.1453 |
| MRPL37 | mitochondrial ribosomal protein L37 | -2.1439 |
| SRSF2 | serine/arginine-rich splicing factor 2 | -2.14188 |
| NECTIN3 | nectin cell adhesion molecule 3 | -2.1353 |
| URB2 | URB2 ribosome biogenesis 2 homolog (S. cerevisiae) | -2.13495 |
| COX10 | COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor | -2.13315 |
| DDX27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 | -2.13188 |
| TXLNG | taxilin gamma | -2.1218 |
| CSAG2 | CSAG family, member 2 | -2.11895 |
| PHF20 | PHD finger protein 20 | -2.11665 |
| PDE8A | phosphodiesterase 8A | -2.1128 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -2.1125 |
| SPAG5 | sperm associated antigen 5 | -2.10275 |
| CIAPIN1 | cytokine induced apoptosis inhibitor 1 | -2.10113 |
| JMJD6 | jumonji domain containing 6 | -2.09602 |
| OSBPL11 | oxysterol binding protein-like 11 | -2.0956 |
| LAMB1 | laminin, beta 1 | -2.09375 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -2.09238 |
| FNBP1L | formin binding protein 1-like | -2.0911 |
| ANKRD10 | ankyrin repeat domain 10 | -2.08205 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -2.07947 |
| MKI67 | marker of proliferation Ki-67 | -2.07313 |
| NCOA6 | nuclear receptor coactivator 6 | -2.0608 |
| NUFIP1 | nuclear fragile X mental retardation protein interacting protein 1 | -2.0573 |
| BANP | BTG3 associated nuclear protein | -2.04505 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -2.0446 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -2.03833 |
| MAGEA6 | melanoma antigen family A6 | -2.03807 |
| NOL9 | nucleolar protein 9 | -2.0345 |
| RBM12B | RNA binding motif protein 12B | -2.0329 |
| POGK | pogo transposable element with KRAB domain | -2.03185 |
| PSMC4 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | -2.0311 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -2.0284 |
| MPZL1 | myelin protein zero-like 1 | -2.01622 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -2.01428 |
| GPSM2 | G-protein signaling modulator 2 | -2.0119 |
| KIF22 | kinesin family member 22 | -2.01055 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | -2.00933 |
| CETN3 | centrin, EF-hand protein, 3 | -2.0056 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -2.00515 |
