CRCGN017_MCF10A.WT.HP_24H:G03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tris(1-chloro-2-propanyl) phosphate 11.22 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:G03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.91866
ABHD6 abhydrolase domain containing 6 3.77894
HBB hemoglobin, beta 3.59457
UGDH UDP-glucose 6-dehydrogenase 3.10216
CERK ceramide kinase 2.73983
SYNE2 spectrin repeat containing, nuclear envelope 2 2.6034
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.44396
EAPP E2F-associated phosphoprotein 2.36384
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.33389
PKN1 protein kinase N1 2.28793
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.23213
GRB10 growth factor receptor-bound protein 10 2.18389
ZMIZ1 zinc finger, MIZ-type containing 1 2.1748
ACAA1 acetyl-CoA acyltransferase 1 2.14359
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.12539
MGAM maltase-glucoamylase 2.04037
RSF1 remodeling and spacing factor 1 2.03523

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -4.07077
CD81 CD81 molecule -3.67819
DNM1L dynamin 1-like -2.96192
HSPA1A heat shock 70kDa protein 1A -2.80345
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.79449
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.7918
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.72168
SCAND1 SCAN domain containing 1 -2.65002
RALGDS ral guanine nucleotide dissociation stimulator -2.5249
ETFB electron-transfer-flavoprotein, beta polypeptide -2.36253
KRT14 keratin 14, type I -2.23905
MSMO1 methylsterol monooxygenase 1 -2.21702
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.10416
PPIE peptidylprolyl isomerase E (cyclophilin E) -2.05605
GADD45B growth arrest and DNA-damage-inducible, beta -2.02362