CRCGN017_MCF10A.WT.HP_24H:G04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1-dichloroethane 97.43 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:G04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.20585
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.71687
ACAA1 acetyl-CoA acyltransferase 1 4.41314
WFS1 Wolfram syndrome 1 (wolframin) 3.966
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 3.52184
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.633
TBX2 T-box 2 2.35557
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 2.35151
COQ8A coenzyme Q8A 2.32577
SEC24C SEC24 family member C 2.32324
PTPN3 protein tyrosine phosphatase, non-receptor type 3 2.23719
LAMP3 lysosomal-associated membrane protein 3 2.23303
LY75-CD302 LY75-CD302 readthrough 2.23244
LPAR1 lysophosphatidic acid receptor 1 2.22665
CDK20 cyclin-dependent kinase 20 2.18203
LOC128966597 MAL-like protein 2.16898
MID1IP1 MID1 interacting protein 1 2.1406
PMM1 phosphomannomutase 1 2.0614
PTMA prothymosin, alpha 2.05355
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 2.02964

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -5.88501
DSG2 desmoglein 2 -5.33483
CYCS cytochrome c, somatic -5.23793
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.68197
CCDC86 coiled-coil domain containing 86 -4.38223
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.65751
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -3.47787
ITGB1BP1 integrin beta 1 binding protein 1 -3.34765
CCNB1 cyclin B1 -2.75882
NME7 NME/NM23 family member 7 -2.6496
IFRD2 interferon-related developmental regulator 2 -2.56791
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.46419
ELP4 elongator acetyltransferase complex subunit 4 -2.42815
NT5DC2 5'-nucleotidase domain containing 2 -2.23641
CDKN2A cyclin-dependent kinase inhibitor 2A -2.22951
TMEM115 transmembrane protein 115 -2.12089
BLCAP bladder cancer associated protein -2.09612
TRIM44 tripartite motif containing 44 -2.08789
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.056
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.05145
CRIPT cysteine-rich PDZ-binding protein -2.01919