CRCGN017_MCF10A.WT.HP_24H:G05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1-dichloroethane 32.48 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:G05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KLHL21 kelch-like family member 21 7.75206
SPAG4 sperm associated antigen 4 5.78924
PPARG peroxisome proliferator-activated receptor gamma 4.75153
TBX2 T-box 2 4.11087
ACAA1 acetyl-CoA acyltransferase 1 3.78016
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.77713
ANO1 anoctamin 1, calcium activated chloride channel 3.0272
GPATCH8 G patch domain containing 8 2.95015
CCNA1 cyclin A1 2.68804
STIMATE STIM activating enhancer 2.68781
ECD ecdysoneless homolog (Drosophila) 2.5984
NOL9 nucleolar protein 9 2.55787
IDE insulin-degrading enzyme 2.39266
CRELD2 cysteine-rich with EGF-like domains 2 2.34668
MSRA methionine sulfoxide reductase A 2.22841
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.2209
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.20327
MICA MHC class I polypeptide-related sequence A 2.13176
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.07761
FAM13A family with sequence similarity 13, member A 2.05207

decreased expression

Symbol Name Standardized Value
NT5DC2 5'-nucleotidase domain containing 2 -3.47018
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.09988
GDF15 growth differentiation factor 15 -2.83578
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.74994
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.71197
ATF5 activating transcription factor 5 -2.6994
VAT1 vesicle amine transport 1 -2.69874
ENOPH1 enolase-phosphatase 1 -2.68229
CHMP4B charged multivesicular body protein 4B -2.58788
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.43099
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.35785
TUBB6 tubulin, beta 6 class V -2.30487
MTERF3 mitochondrial transcription termination factor 3 -2.28244
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.27905
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.2789
S100A8 S100 calcium binding protein A8 -2.27877
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.27537
CDC20 cell division cycle 20 -2.18666
RBM12B RNA binding motif protein 12B -2.1369
STXBP2 syntaxin binding protein 2 -2.07745
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.03602