CRCGN017_MCF10A.WT.HP_24H:G06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1-dichloroethane 10.83 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:G06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 4.82905
SSBP2 single-stranded DNA binding protein 2 4.76915
SPAG4 sperm associated antigen 4 4.64488
NOSIP nitric oxide synthase interacting protein 3.15845
UBQLN2 ubiquilin 2 2.92635
CXCR4 chemokine (C-X-C motif) receptor 4 2.91726
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.78576
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.72447
BMP4 bone morphogenetic protein 4 2.58574
HBB hemoglobin, beta 2.5435
GRB10 growth factor receptor-bound protein 10 2.49695
OLFML2B olfactomedin-like 2B 2.47853
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.37299
WIF1 WNT inhibitory factor 1 2.27911
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.26836
NR1H3 nuclear receptor subfamily 1, group H, member 3 2.18743
ZBTB35 zinc finger and BTB domain containing 35 2.15324
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.11312
LYRM1 LYR motif containing 1 2.04028
HBA1 hemoglobin, alpha 1 2.0003

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -4.77037
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.40771
ACOT9 acyl-CoA thioesterase 9 -3.62568
GDF15 growth differentiation factor 15 -2.79374
FBXO21 F-box protein 21 -2.77759
TUBB6 tubulin, beta 6 class V -2.77231
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.74804
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.56512
RGS2 regulator of G-protein signaling 2 -2.31326
ENOPH1 enolase-phosphatase 1 -2.23806
S100A8 S100 calcium binding protein A8 -2.09735
REEP5 receptor accessory protein 5 -2.00466