CRCGN017_MCF10A.WT.HP_24H:G08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-phenyl-2-thiourea 34.16 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

117 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:G08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.4634
AMDHD2 amidohydrolase domain containing 2 5.3534
RBM6 RNA binding motif protein 6 5.2796
ZW10 zw10 kinetochore protein 5.0169
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.99535
LOXL1 lysyl oxidase-like 1 4.7159
PEX11A peroxisomal biogenesis factor 11 alpha 4.6852
HBA1 hemoglobin, alpha 1 3.17024
SQOR sulfide quinone oxidoreductase 3.14035
CNRIP1 cannabinoid receptor interacting protein 1 3.0669
MCUR1 mitochondrial calcium uniporter regulator 1 3.02015
CTSZ cathepsin Z 2.9204
KDM5D lysine (K)-specific demethylase 5D 2.84255
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 2.6791
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.65205
POGLUT2 protein O-glucosyltransferase 2 2.53325
PCOLCE procollagen C-endopeptidase enhancer 2.51415
LRRC61 leucine rich repeat containing 61 2.5094
TMEM248 transmembrane protein 248 2.49775
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.49135
MACROH2A2 macroH2A.2 histone 2.4669
MXRA8 matrix-remodelling associated 8 2.4444
MAGEF1 melanoma antigen family F1 2.39825
SFMBT1 Scm-like with four mbt domains 1 2.3094
PHOX2A paired-like homeobox 2a 2.30915
MTARC1 mitochondrial amidoxime reducing component 1 2.30765
MAGEA1 melanoma antigen family A1 2.30495
NAE1 NEDD8 activating enzyme E1 subunit 1 2.265
FCHO1 FCH domain only 1 2.2255
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.2166
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 2.2084
ANKRD17 ankyrin repeat domain 17 2.19995
FKTN fukutin 2.1852
SLIT2 slit homolog 2 (Drosophila) 2.17025
NPIPB6 nuclear pore complex interacting protein family, member B6 2.15705
CTPS2 CTP synthase 2 2.14045
TMEM186 transmembrane protein 186 2.1396
GMPS guanine monphosphate synthase 2.1296
MED4 mediator complex subunit 4 2.11245
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.10327
HOXC10 homeobox C10 2.0974
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.09665
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 2.0881
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 2.08405
COL16A1 collagen, type XVI, alpha 1 2.08295
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 2.0734
CSAG2 CSAG family, member 2 2.0615
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough 2.0498
RAD54L RAD54-like (S. cerevisiae) 2.03305
THOC1 THO complex 1 2.0296
IBSP integrin-binding sialoprotein 2.0264
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.0102
WDR3 WD repeat domain 3 2.00205

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -10.0
SCYL3 SCY1-like 3 (S. cerevisiae) -6.4499
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.31245
RNF167 ring finger protein 167 -5.30505
NPDC1 neural proliferation, differentiation and control, 1 -5.28425
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.9062
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -4.84725
BASP1 brain abundant, membrane attached signal protein 1 -4.73285
BAG3 BCL2-associated athanogene 3 -4.61645
MRPS16 mitochondrial ribosomal protein S16 -4.55965
SLC35F2 solute carrier family 35, member F2 -4.48985
HMG20B high mobility group 20B -4.44802
TUBA4A tubulin, alpha 4a -4.13395
NRIP1 nuclear receptor interacting protein 1 -3.99227
HOXA5 homeobox A5 -3.86015
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.60197
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -3.46225
C1QBP complement component 1, q subcomponent binding protein -3.28175
PFN1 profilin 1 -3.1408
SGK1 serum/glucocorticoid regulated kinase 1 -3.03555
FAM107A family with sequence similarity 107, member A -3.0219
CD81 CD81 molecule -2.9875
PLK1 polo-like kinase 1 -2.8872
VWF von Willebrand factor -2.7045
EMC6 ER membrane protein complex subunit 6 -2.69475
VWA1 von Willebrand factor A domain containing 1 -2.62205
CHI3L2 chitinase 3-like 2 -2.46655
SIRT2 sirtuin 2 -2.40465
CXCL13 chemokine (C-X-C motif) ligand 13 -2.40265
ACAA1 acetyl-CoA acyltransferase 1 -2.39995
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -2.3459
HIGD1B HIG1 hypoxia inducible domain family, member 1B -2.34
WASHC4 WASH complex subunit 4 -2.32393
QPCT glutaminyl-peptide cyclotransferase -2.28385
USP9X ubiquitin specific peptidase 9, X-linked -2.2562
HLA-DMB major histocompatibility complex, class II, DM beta -2.2493
PUDP pseudouridine 5'-phosphatase -2.237
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -2.2152
BCAS1 breast carcinoma amplified sequence 1 -2.20585
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 -2.20345
KLK11 kallikrein-related peptidase 11 -2.2026
KDM6A lysine (K)-specific demethylase 6A -2.2
MRM3 mitochondrial rRNA methyltransferase 3 -2.194
NRIP3 nuclear receptor interacting protein 3 -2.18235
HLA-DMA major histocompatibility complex, class II, DM alpha -2.169
CLDN5 claudin 5 -2.1503
CPM carboxypeptidase M -2.14905
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 -2.14645
NT5C2 5'-nucleotidase, cytosolic II -2.1416
ARID4B AT rich interactive domain 4B (RBP1-like) -2.1266
EXOC3 exocyst complex component 3 -2.1207
SARAF store-operated calcium entry-associated regulatory factor -2.1009
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.1003
CD82 CD82 molecule -2.0944
CYB5R1 cytochrome b5 reductase 1 -2.09035
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.0845
LCK LCK proto-oncogene, Src family tyrosine kinase -2.08003
CD52 CD52 molecule -2.07568
FKBP1C FK506 binding protein 1C -2.06155
NEFH neurofilament, heavy polypeptide -2.03697
NMRK1 nicotinamide riboside kinase 1 -2.01815
PHLDA3 pleckstrin homology-like domain, family A, member 3 -2.00455
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -2.00455
NOCT nocturnin -2.00355