CRCGN017_MCF10A.WT.HP_24H:G09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-phenyl-2-thiourea 11.39 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

167 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:G09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.18825
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.42165
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 4.17835
HBA1 hemoglobin, alpha 1 3.60566
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.47778
HBB hemoglobin, beta 3.3835
PRPS2 phosphoribosyl pyrophosphate synthetase 2 3.33295
VAV3 vav 3 guanine nucleotide exchange factor 3.137
MICALL1 MICAL-like 1 2.99977
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.77495
GTPBP8 GTP-binding protein 8 (putative) 2.5985
EPHX3 epoxide hydrolase 3 2.5776
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 2.56365
PAQR3 progestin and adipoQ receptor family member III 2.56265
WASF3 WAS protein family, member 3 2.53125
CTSO cathepsin O 2.51055
MARCKSL1 MARCKS-like 1 2.489
IFI35 interferon-induced protein 35 2.47635
LYN LYN proto-oncogene, Src family tyrosine kinase 2.45177
LHFPL2 lipoma HMGIC fusion partner-like 2 2.4488
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 2.44255
AGA aspartylglucosaminidase 2.42033
SF3B4 splicing factor 3b, subunit 4, 49kDa 2.40075
UBE2D1 ubiquitin-conjugating enzyme E2D 1 2.38333
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 2.3779
IRF2 interferon regulatory factor 2 2.37735
FAM184A family with sequence similarity 184, member A 2.3597
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.3468
GADD45G growth arrest and DNA-damage-inducible, gamma 2.3454
ALCAM activated leukocyte cell adhesion molecule 2.34235
GRAMD4 GRAM domain containing 4 2.336
CENPC centromere protein C 2.29975
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.2926
ARMCX5 armadillo repeat containing, X-linked 5 2.2899
ARB2A ARB2 cotranscriptional regulator A 2.2654
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.25515
LY75-CD302 LY75-CD302 readthrough 2.2327
PRR7 proline rich 7 (synaptic) 2.2311
TULP4 tubby like protein 4 2.2223
MSL2 male-specific lethal 2 homolog (Drosophila) 2.20725
HEATR3 HEAT repeat containing 3 2.19515
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.1946
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.19145
GBE1 glucan (1,4-alpha-), branching enzyme 1 2.18695
PLP1 proteolipid protein 1 2.166
DLK1 delta-like 1 homolog (Drosophila) 2.16195
TM4SF1 transmembrane 4 L six family member 1 2.15703
OGFRL1 opioid growth factor receptor-like 1 2.154
DMAC2 distal membrane arm assembly component 2 2.15133
HDAC4 histone deacetylase 4 2.14595
DENND1C DENN/MADD domain containing 1C 2.1397
CD96 CD96 molecule 2.1274
RALY RALY heterogeneous nuclear ribonucleoprotein 2.11525
SPRY2 sprouty homolog 2 (Drosophila) 2.1116
OSTM1 osteopetrosis associated transmembrane protein 1 2.10705
ACSL5 acyl-CoA synthetase long-chain family member 5 2.10475
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 2.10275
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 2.09932
CD40LG CD40 ligand 2.0922
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 2.0866
IL21 interleukin 21 2.085
STAT5A signal transducer and activator of transcription 5A 2.0834
TRIM5 tripartite motif containing 5 2.078
LRRC20 leucine rich repeat containing 20 2.07435
MBNL1 muscleblind-like splicing regulator 1 2.07343
RNF43 ring finger protein 43 2.0683
FRG1 FSHD region gene 1 2.05605
ZBTB38 zinc finger and BTB domain containing 38 2.0557
TMEM123 transmembrane protein 123 2.05225
GNG12 guanine nucleotide binding protein (G protein), gamma 12 2.03985
GATA3 GATA binding protein 3 2.03575
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.0301
BICRAL BICRA like chromatin remodeling complex associated protein 2.02675
RBL1 retinoblastoma-like 1 2.0192

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -10.0
NPDC1 neural proliferation, differentiation and control, 1 -9.8215
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -7.14845
LDHD lactate dehydrogenase D -5.08475
TEX10 testis expressed 10 -5.0613
KIF14 kinesin family member 14 -4.8731
XPO7 exportin 7 -4.26095
TRAPPC3 trafficking protein particle complex 3 -3.98517
UBE3C ubiquitin protein ligase E3C -3.73095
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.55085
KRT14 keratin 14, type I -3.53975
COG5 component of oligomeric golgi complex 5 -3.4538
VTI1B vesicle transport through interaction with t-SNAREs 1B -3.40615
ERGIC2 ERGIC and golgi 2 -3.3856
IPO8 importin 8 -3.3381
MED21 mediator complex subunit 21 -3.26528
RNF167 ring finger protein 167 -3.12875
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) -3.12768
COPS7A COP9 signalosome subunit 7A -3.0019
RNF146 ring finger protein 146 -2.861
WDR26 WD repeat domain 26 -2.8512
CAPRIN2 caprin family member 2 -2.8446
SPATS2 spermatogenesis associated, serine-rich 2 -2.823
NGRN neugrin, neurite outgrowth associated -2.8171
SRPK2 SRSF protein kinase 2 -2.77932
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.7608
TRAPPC14 trafficking protein particle complex subunit 14 -2.7457
INTS13 integrator complex subunit 13 -2.67295
SCYL2 SCY1-like 2 (S. cerevisiae) -2.6435
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) -2.61475
JAK1 Janus kinase 1 -2.5571
RFXAP regulatory factor X-associated protein -2.53805
PKP2 plakophilin 2 -2.50755
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -2.50347
HTD2 hydroxyacyl-thioester dehydratase type 2 -2.5006
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -2.49475
CRYZL1 crystallin, zeta (quinone reductase)-like 1 -2.48545
SINHCAF SIN3-HDAC complex associated factor -2.48475
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent -2.4609
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -2.45125
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 -2.44405
MLF2 myeloid leukemia factor 2 -2.43165
POM121 POM121 transmembrane nucleoporin -2.41245
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.4117
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.4104
MRPL39 mitochondrial ribosomal protein L39 -2.40575
LIG4 ligase IV, DNA, ATP-dependent -2.39375
FGD1 FYVE, RhoGEF and PH domain containing 1 -2.38525
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa -2.3848
EXOC5 exocyst complex component 5 -2.3767
BPHL biphenyl hydrolase-like (serine hydrolase) -2.3539
BMAL2 basic helix-loop-helix ARNT like 2 -2.35285
TMBIM1 transmembrane BAX inhibitor motif containing 1 -2.323
TSPAN1 tetraspanin 1 -2.3081
TWSG1 twisted gastrulation BMP signaling modulator 1 -2.29645
AZU1 azurocidin 1 -2.28845
SGPP1 sphingosine-1-phosphate phosphatase 1 -2.26
GATD3 glutamine amidotransferase class 1 domain containing 3 -2.25598
RESF1 retroelement silencing factor 1 -2.25395
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -2.2487
DCTN4 dynactin 4 (p62) -2.22005
MRPS15 mitochondrial ribosomal protein S15 -2.219
RARS1 arginyl-tRNA synthetase 1 -2.21055
UBE2H ubiquitin-conjugating enzyme E2H -2.20688
ZNF12 zinc finger protein 12 -2.19225
LRRC42 leucine rich repeat containing 42 -2.1755
CA2 carbonic anhydrase II -2.1743
IGFBP6 insulin-like growth factor binding protein 6 -2.173
CDK5 cyclin-dependent kinase 5 -2.1718
MBOAT2 membrane bound O-acyltransferase domain containing 2 -2.16845
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -2.1568
USP21 ubiquitin specific peptidase 21 -2.154
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.15115
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) -2.14045
DNM3 dynamin 3 -2.13825
TMEM115 transmembrane protein 115 -2.1319
TULP3 tubby like protein 3 -2.12515
TMEM230 transmembrane protein 230 -2.1244
OGDHL oxoglutarate dehydrogenase-like -2.11955
ZNF510 zinc finger protein 510 -2.11775
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.1149
FAM193A family with sequence similarity 193, member A -2.1066
MDFI MyoD family inhibitor -2.0988
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.0929
DPP3 dipeptidyl-peptidase 3 -2.05485
CNTN1 contactin 1 -2.04805
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -2.04645
LPAR3 lysophosphatidic acid receptor 3 -2.04385
MAVS mitochondrial antiviral signaling protein -2.03675
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -2.02497
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine -2.0127
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.0024
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide -2.00035