CRCGN017_MCF10A.WT.HP_24H:G16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sirolimus 10.0 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

144 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:G16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 6.3552
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.2666
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 5.0578
ZNF586 zinc finger protein 586 4.74685
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 4.3811
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.93795
NUCB2 nucleobindin 2 3.9288
GRB10 growth factor receptor-bound protein 10 3.76707
ZNF587 zinc finger protein 587 3.6231
FHL2 four and a half LIM domains 2 3.503
TXNRD1 thioredoxin reductase 1 3.3661
ACAA1 acetyl-CoA acyltransferase 1 3.15567
STX1A syntaxin 1A (brain) 3.12625
DUSP4 dual specificity phosphatase 4 2.99038
CCL2 chemokine (C-C motif) ligand 2 2.9611
ZNF134 zinc finger protein 134 2.94655
SLC75A1 solute carrier family 75 member 1 2.9343
ZNF587B zinc finger protein 587B 2.9019
SQSTM1 sequestosome 1 2.87795
HMGA2 high mobility group AT-hook 2 2.8291
TM9SF3 transmembrane 9 superfamily member 3 2.7727
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.7669
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.75685
SCCPDH saccharopine dehydrogenase (putative) 2.7564
TMEM147 transmembrane protein 147 2.62425
RBKS ribokinase 2.62133
PYGL phosphorylase, glycogen, liver 2.6083
GLRX glutaredoxin (thioltransferase) 2.59275
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase 2.57335
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.56645
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 2.53055
CHIC2 cysteine-rich hydrophobic domain 2 2.50505
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.48072
SQOR sulfide quinone oxidoreductase 2.4062
SPRY2 sprouty homolog 2 (Drosophila) 2.3909
KLHL21 kelch-like family member 21 2.3563
PUS7 pseudouridylate synthase 7 (putative) 2.35605
SLC39A14 solute carrier family 39 (zinc transporter), member 14 2.3547
FNDC3B fibronectin type III domain containing 3B 2.3382
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 2.32999
FOSL1 FOS-like antigen 1 2.3246
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.27965
ABHD14A abhydrolase domain containing 14A 2.24095
PRAF2 PRA1 domain family, member 2 2.22865
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.2208
CHMP2A charged multivesicular body protein 2A 2.22055
RBFA ribosome binding factor A (putative) 2.2074
TFF3 trefoil factor 3 (intestinal) 2.1998
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 2.18248
PKM pyruvate kinase, muscle 2.16818
CTSL cathepsin L 2.16785
ZNF783 zinc finger family member 783 2.16375
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.15505
DEFA3 defensin, alpha 3, neutrophil-specific 2.1541
VKORC1 vitamin K epoxide reductase complex, subunit 1 2.1433
DVL1 dishevelled segment polarity protein 1 2.14145
GAA glucosidase, alpha; acid 2.13415
CHMP4B charged multivesicular body protein 4B 2.1302
ATRAID all-trans retinoic acid-induced differentiation factor 2.1022
RPH3AL rabphilin 3A-like (without C2 domains) 2.10045
CNPY3 canopy FGF signaling regulator 3 2.0938
LRP10 low density lipoprotein receptor-related protein 10 2.0826
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 2.07805
CNPY2 canopy FGF signaling regulator 2 2.05668
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 2.0288
TEX264 testis expressed 264 2.02565
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.0127
ZNF544 zinc finger protein 544 2.006

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -9.30055
LAP3 leucine aminopeptidase 3 -5.0878
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.62752
TES testin LIM domain protein -4.60612
PRPF4 pre-mRNA processing factor 4 -4.43267
HSPA8 heat shock 70kDa protein 8 -4.38997
MSMO1 methylsterol monooxygenase 1 -4.29195
ANKRD10 ankyrin repeat domain 10 -3.7781
PRR15L proline rich 15-like -3.70135
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.60653
TSC22D3 TSC22 domain family, member 3 -3.30643
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.26525
ARID4B AT rich interactive domain 4B (RBP1-like) -3.08005
NGRN neugrin, neurite outgrowth associated -3.00695
ALDOC aldolase C, fructose-bisphosphate -2.9722
INSIG1 insulin induced gene 1 -2.95168
SESN1 sestrin 1 -2.90935
SGK1 serum/glucocorticoid regulated kinase 1 -2.90265
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.89728
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.79055
PSIP1 PC4 and SFRS1 interacting protein 1 -2.74107
PDCD10 programmed cell death 10 -2.7254
MRPL49 mitochondrial ribosomal protein L49 -2.71885
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.62142
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.57615
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit -2.52965
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -2.5258
ZCCHC10 zinc finger, CCHC domain containing 10 -2.50405
TRIB3 tribbles pseudokinase 3 -2.49245
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -2.473
DDIT4 DNA-damage-inducible transcript 4 -2.4534
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.41645
ATG4A autophagy related 4A, cysteine peptidase -2.40115
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.3857
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase -2.3509
TJP2 tight junction protein 2 -2.34755
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 -2.3312
EPN3 epsin 3 -2.33095
VPS33B vacuolar protein sorting 33 homolog B (yeast) -2.26435
CNOT1 CCR4-NOT transcription complex, subunit 1 -2.2519
FMR1 fragile X mental retardation 1 -2.23945
CD58 CD58 molecule -2.22343
CCNC cyclin C -2.22215
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -2.2201
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -2.20575
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B -2.19025
CYCS cytochrome c, somatic -2.18235
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough -2.18045
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.172
SYBU syntabulin (syntaxin-interacting) -2.17045
PLAAT2 phospholipase A and acyltransferase 2 -2.1644
FKBP15 FK506 binding protein 15, 133kDa -2.15655
WASHC4 WASH complex subunit 4 -2.15265
TLR7 toll-like receptor 7 -2.143
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -2.13617
BAD BCL2-associated agonist of cell death -2.1309
TCN2 transcobalamin II -2.1239
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -2.12033
MEIS1 Meis homeobox 1 -2.10915
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.10695
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 -2.10105
CDC40 cell division cycle 40 -2.09218
PLEKHS1 pleckstrin homology domain containing, family S member 1 -2.088
RIC8B RIC8 guanine nucleotide exchange factor B -2.08695
STAP2 signal transducing adaptor family member 2 -2.08485
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.06995
CAPN1 calpain 1, (mu/I) large subunit -2.0677
PGAM4 phosphoglycerate mutase family member 4 -2.0656
SPRR1A small proline-rich protein 1A -2.05405
NOTCH1 notch 1 -2.054
PSRC1 proline/serine-rich coiled-coil 1 -2.0319
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -2.01945
MMP10 matrix metallopeptidase 10 -2.0108
CAAP1 caspase activity and apoptosis inhibitor 1 -2.00885
PLXNB2 plexin B2 -2.0083
KLF10 Kruppel-like factor 10 -2.00375