| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | sirolimus 3.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome) |
| Similar Terms | |
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99 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:G17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AGR2 | anterior gradient 2 | 5.68275 |
| E2F2 | E2F transcription factor 2 | 5.49485 |
| PPARG | peroxisome proliferator-activated receptor gamma | 5.4265 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 4.3546 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 4.02 |
| RBKS | ribokinase | 3.96775 |
| TBX2 | T-box 2 | 3.40457 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 3.32425 |
| HMGA2 | high mobility group AT-hook 2 | 3.1209 |
| STXBP1 | syntaxin binding protein 1 | 3.1186 |
| ACAA1 | acetyl-CoA acyltransferase 1 | 3.05665 |
| MSRA | methionine sulfoxide reductase A | 3.0487 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 3.0388 |
| NARS2 | asparaginyl-tRNA synthetase 2, mitochondrial (putative) | 2.8603 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 2.8544 |
| FHL2 | four and a half LIM domains 2 | 2.82355 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.74268 |
| NENF | neudesin neurotrophic factor | 2.64447 |
| AAMDC | adipogenesis associated, Mth938 domain containing | 2.64352 |
| P3H3 | prolyl 3-hydroxylase 3 | 2.62535 |
| PKN1 | protein kinase N1 | 2.6203 |
| TSPAN4 | tetraspanin 4 | 2.59637 |
| TBCA | tubulin folding cofactor A | 2.5925 |
| VPREB1 | pre-B lymphocyte 1 | 2.48805 |
| STN1 | STN1 subunit of CST complex | 2.42255 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 2.34823 |
| GAA | glucosidase, alpha; acid | 2.32625 |
| COPZ1 | coatomer protein complex, subunit zeta 1 | 2.32255 |
| CHMP4B | charged multivesicular body protein 4B | 2.28188 |
| GAB2 | GRB2-associated binding protein 2 | 2.2746 |
| PYGL | phosphorylase, glycogen, liver | 2.26815 |
| DUSP4 | dual specificity phosphatase 4 | 2.24097 |
| TPD52L2 | tumor protein D52-like 2 | 2.20685 |
| TRIP6 | thyroid hormone receptor interactor 6 | 2.18785 |
| LOC107986346 | mitochondrial import receptor subunit TOM7 homolog | 2.1764 |
| DHRS4 | dehydrogenase/reductase (SDR family) member 4 | 2.15445 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 2.11315 |
| PRAF2 | PRA1 domain family, member 2 | 2.09985 |
| FBXL4 | F-box and leucine-rich repeat protein 4 | 2.0816 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 2.06652 |
| ALG8 | ALG8, alpha-1,3-glucosyltransferase | 2.0661 |
| GLOD4 | glyoxalase domain containing 4 | 2.0651 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 2.0507 |
| ADD3 | adducin 3 (gamma) | 2.04399 |
| SQOR | sulfide quinone oxidoreductase | 2.0438 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 2.02015 |
| TMEM50A | transmembrane protein 50A | 2.0185 |
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | 2.01355 |
| PLEK2 | pleckstrin 2 | 2.0047 |
| CRTAP | cartilage associated protein | 2.00295 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNB2 | cyclin B2 | -5.39695 |
| LAP3 | leucine aminopeptidase 3 | -5.15265 |
| CAB39 | calcium binding protein 39 | -5.11135 |
| KIF20A | kinesin family member 20A | -4.93925 |
| TXNDC9 | thioredoxin domain containing 9 | -4.57088 |
| HMG20B | high mobility group 20B | -4.2527 |
| MT2A | metallothionein 2A | -3.6955 |
| ANKRD10 | ankyrin repeat domain 10 | -3.67415 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -3.41092 |
| PRR15L | proline rich 15-like | -3.3931 |
| GDF15 | growth differentiation factor 15 | -3.3708 |
| BID | BH3 interacting domain death agonist | -3.10987 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -3.00818 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -2.8807 |
| INSIG1 | insulin induced gene 1 | -2.87542 |
| ZCCHC10 | zinc finger, CCHC domain containing 10 | -2.87335 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -2.7789 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | -2.5829 |
| MT1X | metallothionein 1X | -2.50493 |
| PEX13 | peroxisomal biogenesis factor 13 | -2.46895 |
| MAIP1 | matrix AAA peptidase interacting protein 1 | -2.44415 |
| PSMD5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | -2.40625 |
| SULT1E1 | sulfotransferase family 1E, estrogen-preferring, member 1 | -2.38905 |
| SLC35A1 | solute carrier family 35 (CMP-sialic acid transporter), member A1 | -2.38395 |
| TLK2 | tousled-like kinase 2 | -2.36365 |
| LMAN2L | lectin, mannose-binding 2-like | -2.3593 |
| FAM13B | family with sequence similarity 13, member B | -2.3413 |
| KIF3B | kinesin family member 3B | -2.33325 |
| HSPB1 | heat shock 27kDa protein 1 | -2.3306 |
| ACOX3 | acyl-CoA oxidase 3, pristanoyl | -2.31868 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -2.3127 |
| UEVLD | UEV and lactate/malate dehyrogenase domains | -2.305 |
| MRPL35 | mitochondrial ribosomal protein L35 | -2.2801 |
| MAPKAPK3 | mitogen-activated protein kinase-activated protein kinase 3 | -2.26242 |
| PFN1 | profilin 1 | -2.2501 |
| TSC22D3 | TSC22 domain family, member 3 | -2.20557 |
| TRPS1 | trichorhinophalangeal syndrome I | -2.1875 |
| RNASE2 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | -2.1518 |
| TRIM37 | tripartite motif containing 37 | -2.13875 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | -2.11727 |
| NDUFS1 | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | -2.1136 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | -2.10325 |
| ZSCAN16 | zinc finger and SCAN domain containing 16 | -2.0975 |
| TMEM127 | transmembrane protein 127 | -2.08335 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -2.05622 |
| TRIM26 | tripartite motif containing 26 | -2.04595 |
| BARD1 | BRCA1 associated RING domain 1 | -2.04365 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -2.03105 |
| OSBPL11 | oxysterol binding protein-like 11 | -2.00545 |
