| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | sirolimus 1.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome) |
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81 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:G18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SNAP25 | synaptosomal-associated protein, 25kDa | 4.9616 |
| GPER1 | G protein-coupled estrogen receptor 1 | 4.62413 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 4.374 |
| CERK | ceramide kinase | 3.48165 |
| DUSP11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | 3.3216 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 3.2409 |
| GPATCH8 | G patch domain containing 8 | 3.1462 |
| HMGA2 | high mobility group AT-hook 2 | 2.86785 |
| MEAF6 | MYST/Esa1-associated factor 6 | 2.861 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 2.8386 |
| ADAT1 | adenosine deaminase, tRNA-specific 1 | 2.7826 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | 2.78 |
| FHL2 | four and a half LIM domains 2 | 2.76625 |
| TSPAN4 | tetraspanin 4 | 2.68555 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | 2.641 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 2.60892 |
| RLIM | ring finger protein, LIM domain interacting | 2.5935 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | 2.5903 |
| ZNF862 | zinc finger protein 862 | 2.5539 |
| KIFBP | kinesin family binding protein | 2.5516 |
| DCP1A | decapping mRNA 1A | 2.54035 |
| EIF3L | eukaryotic translation initiation factor 3, subunit L | 2.4704 |
| LARP1 | La ribonucleoprotein domain family, member 1 | 2.39752 |
| PTK2 | protein tyrosine kinase 2 | 2.37885 |
| CHGB | chromogranin B | 2.3644 |
| RBKS | ribokinase | 2.35232 |
| TXNRD3 | thioredoxin reductase 3 | 2.3037 |
| CYREN | cell cycle regulator of NHEJ | 2.27875 |
| CD5 | CD5 molecule | 2.277 |
| STX1A | syntaxin 1A (brain) | 2.2527 |
| ERCC1 | excision repair cross-complementation group 1 | 2.22097 |
| PABPC3 | poly(A) binding protein, cytoplasmic 3 | 2.22055 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 2.1582 |
| EIF3D | eukaryotic translation initiation factor 3, subunit D | 2.099 |
| RSBN1 | round spermatid basic protein 1 | 2.0943 |
| OLA1 | Obg-like ATPase 1 | 2.0797 |
| STMN2 | stathmin 2 | 2.06892 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 2.06108 |
| UNC13D | unc-13 homolog D (C. elegans) | 2.0596 |
| DENND1C | DENN/MADD domain containing 1C | 2.05285 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 2.0523 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 2.0351 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ISOC1 | isochorismatase domain containing 1 | -5.40165 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -4.8442 |
| PRR15L | proline rich 15-like | -3.48685 |
| XPO7 | exportin 7 | -3.45705 |
| CHMP4B | charged multivesicular body protein 4B | -3.4209 |
| CIAPIN1 | cytokine induced apoptosis inhibitor 1 | -3.02888 |
| PRCP | prolylcarboxypeptidase (angiotensinase C) | -2.9733 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.88592 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -2.8335 |
| SNX7 | sorting nexin 7 | -2.8157 |
| INSIG1 | insulin induced gene 1 | -2.75947 |
| TSC22D3 | TSC22 domain family, member 3 | -2.7224 |
| KRT14 | keratin 14, type I | -2.6275 |
| BIRC3 | baculoviral IAP repeat containing 3 | -2.55235 |
| FAIM | Fas apoptotic inhibitory molecule | -2.5488 |
| SLC35A1 | solute carrier family 35 (CMP-sialic acid transporter), member A1 | -2.506 |
| WNT2 | wingless-type MMTV integration site family member 2 | -2.5037 |
| DCN | decorin | -2.47799 |
| FCN3 | ficolin (collagen/fibrinogen domain containing) 3 | -2.4689 |
| GDF15 | growth differentiation factor 15 | -2.44465 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | -2.4229 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.3988 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -2.3681 |
| DDIT4 | DNA-damage-inducible transcript 4 | -2.3237 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | -2.2146 |
| S100A8 | S100 calcium binding protein A8 | -2.21265 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -2.20316 |
| EIF2B5 | eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa | -2.16355 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -2.16045 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -2.15595 |
| PAX9 | paired box 9 | -2.1459 |
| FCHSD2 | FCH and double SH3 domains 2 | -2.0844 |
| ABHD4 | abhydrolase domain containing 4 | -2.08045 |
| FPGS | folylpolyglutamate synthase | -2.0589 |
| ESRP1 | epithelial splicing regulatory protein 1 | -2.05085 |
| QTMAN | queuosine-tRNA mannosyltransferase | -2.03845 |
| COQ9 | coenzyme Q9 | -2.02845 |
| CCNC | cyclin C | -2.00115 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -2.0005 |
