CRCGN017_MCF10A.WT.HP_24H:G19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methylene chloride 98.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

112 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:G19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.21637
SNAP25 synaptosomal-associated protein, 25kDa 4.9467
HMOX1 heme oxygenase 1 4.7428
CXCR4 chemokine (C-X-C motif) receptor 4 4.69602
CNRIP1 cannabinoid receptor interacting protein 1 4.01035
AGR2 anterior gradient 2 3.5179
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.28967
ACAA1 acetyl-CoA acyltransferase 1 3.22935
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.16092
MYBPC1 myosin binding protein C, slow type 2.9233
PALS2 protein associated with LIN7 2, MAGUK p55 family member 2.7275
PLS1 plastin 1 2.6291
SESN1 sestrin 1 2.5282
FLNB filamin B, beta 2.48242
ARHGAP12 Rho GTPase activating protein 12 2.4588
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like 2.4441
ZNF134 zinc finger protein 134 2.409
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) 2.39707
WDCP WD repeat and coiled coil containing 2.31115
PNKP polynucleotide kinase 3'-phosphatase 2.26715
ABHD2 abhydrolase domain containing 2 2.24874
CH25H cholesterol 25-hydroxylase 2.2389
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 2.22505
TMEM168 transmembrane protein 168 2.21595
MFAP2 microfibrillar-associated protein 2 2.2028
OLFML2B olfactomedin-like 2B 2.1894
OBI1 ORC ubiquitin ligase 1 2.18605
TSPYL5 TSPY-like 5 2.18405
ATG4A autophagy related 4A, cysteine peptidase 2.1775
CTSZ cathepsin Z 2.1712
AQP4 aquaporin 4 2.16796
ZC3H14 zinc finger CCCH-type containing 14 2.15777
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.1477
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 2.1427
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 2.1383
PARG poly (ADP-ribose) glycohydrolase 2.11315
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 2.10965
COQ8A coenzyme Q8A 2.06895
ZNF267 zinc finger protein 267 2.06655
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 2.05175
POLK polymerase (DNA directed) kappa 2.02405
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 2.0084
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 2.00467
ZNF443 zinc finger protein 443 2.00355

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.7378
PFN1 profilin 1 -5.53015
PCNA proliferating cell nuclear antigen -5.0
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.9623
GOLT1B golgi transport 1B -4.7844
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.6551
CHIC2 cysteine-rich hydrophobic domain 2 -4.59525
PCCB propionyl CoA carboxylase, beta polypeptide -4.5421
KIF20A kinesin family member 20A -4.39675
EXOSC4 exosome component 4 -4.03547
PRPF4 pre-mRNA processing factor 4 -3.8274
NRIP1 nuclear receptor interacting protein 1 -3.68783
RNF167 ring finger protein 167 -3.37265
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -3.33855
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -3.316
TMEM230 transmembrane protein 230 -3.1245
S100A8 S100 calcium binding protein A8 -2.9381
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.80835
DDRGK1 DDRGK domain containing 1 -2.77575
SAFB2 scaffold attachment factor B2 -2.76115
PANK2 pantothenate kinase 2 -2.7169
SPTBN2 spectrin, beta, non-erythrocytic 2 -2.6619
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.6533
TXNDC15 thioredoxin domain containing 15 -2.5968
FKBP1C FK506 binding protein 1C -2.42963
HBD hemoglobin, delta -2.42795
CREG1 cellular repressor of E1A-stimulated genes 1 -2.4272
ITM2B integral membrane protein 2B -2.42013
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.3711
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.35755
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.3476
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) -2.3225
WNT4 wingless-type MMTV integration site family, member 4 -2.31325
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.291
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -2.2687
KANK1 KN motif and ankyrin repeat domains 1 -2.26465
CDK9 cyclin-dependent kinase 9 -2.24
UGCG UDP-glucose ceramide glucosyltransferase -2.239
FZD4 frizzled class receptor 4 -2.2283
DERL2 derlin 2 -2.21315
LAMA5 laminin, alpha 5 -2.17385
CENPB centromere protein B, 80kDa -2.1501
YAP1 Yes-associated protein 1 -2.1493
NEO1 neogenin 1 -2.1456
SLC10A3 solute carrier family 10, member 3 -2.14405
SGK1 serum/glucocorticoid regulated kinase 1 -2.1371
AHSP alpha hemoglobin stabilizing protein -2.12965
STARD5 StAR-related lipid transfer (START) domain containing 5 -2.1138
PDGFD platelet derived growth factor D -2.104
INPP5J inositol polyphosphate-5-phosphatase J -2.0987
C1QBP complement component 1, q subcomponent binding protein -2.0899
FOLR3 folate receptor 3 (gamma) -2.0846
ADORA2A adenosine A2a receptor -2.0795
CFI complement factor I -2.07635
NES nestin -2.0741
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -2.06012
BDKRB1 bradykinin receptor B1 -2.04985
RASAL1 RAS protein activator like 1 (GAP1 like) -2.04235
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -2.04215
CDK18 cyclin-dependent kinase 18 -2.02935
PRCP prolylcarboxypeptidase (angiotensinase C) -2.0227
KDM3B lysine (K)-specific demethylase 3B -2.02265
ELOVL4 ELOVL fatty acid elongase 4 -2.0193
CD320 CD320 molecule -2.0124
ARAF A-Raf proto-oncogene, serine/threonine kinase -2.01055
ANAPC2 anaphase promoting complex subunit 2 -2.00955
AMOTL2 angiomotin like 2 -2.00385
NXT1 nuclear transport factor 2-like export factor 1 -2.00275