CRCGN017_MCF10A.WT.HP_24H:G21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methylene chloride 10.98 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

129 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:G21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 6.2927
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.34905
STK10 serine/threonine kinase 10 5.17705
HBA1 hemoglobin, alpha 1 5.12242
WIF1 WNT inhibitory factor 1 5.0
IDE insulin-degrading enzyme 4.884
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 4.7384
HBB hemoglobin, beta 4.36857
USP6NL USP6 N-terminal like 4.0045
TBX2 T-box 2 3.70298
HDAC3 histone deacetylase 3 3.6361
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.58835
LORICRIN loricrin cornified envelope precursor protein 3.5787
POF1B premature ovarian failure, 1B 3.3234
FLG filaggrin 3.2819
KDM5D lysine (K)-specific demethylase 5D 3.12305
SESN1 sestrin 1 3.06365
CPEB3 cytoplasmic polyadenylation element binding protein 3 2.92385
USP9Y ubiquitin specific peptidase 9, Y-linked 2.85545
FCHO1 FCH domain only 1 2.81685
KRT2 keratin 2, type II 2.80605
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.79332
LCE2B late cornified envelope 2B 2.7605
DCTPP1 dCTP pyrophosphatase 1 2.6779
ZFP30 ZFP30 zinc finger protein 2.66075
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.64725
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.62122
PDLIM2 PDZ and LIM domain 2 (mystique) 2.5907
TWSG1 twisted gastrulation BMP signaling modulator 1 2.5731
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.43465
CADM1 cell adhesion molecule 1 2.36618
TMSB4Y thymosin beta 4, Y-linked 2.3574
MLF1 myeloid leukemia factor 1 2.35318
LIN7B lin-7 homolog B (C. elegans) 2.34625
ANXA9 annexin A9 2.34135
PXMP2 peroxisomal membrane protein 2, 22kDa 2.33955
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 2.33275
PPP4R1 protein phosphatase 4, regulatory subunit 1 2.33105
CTNNBIP1 catenin, beta interacting protein 1 2.32005
ESRP2 epithelial splicing regulatory protein 2 2.29795
SCYL2 SCY1-like 2 (S. cerevisiae) 2.29615
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 2.27572
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 2.263
EPHX3 epoxide hydrolase 3 2.24795
RAB32 RAB32, member RAS oncogene family 2.2313
EXPH5 exophilin 5 2.22948
SMAD5 SMAD family member 5 2.22277
ZNF606 zinc finger protein 606 2.21975
GRHL2 grainyhead-like 2 (Drosophila) 2.20455
IFT52 intraflagellar transport 52 2.20275
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.20012
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.19885
DSG1 desmoglein 1 2.1951
PPP1R3D protein phosphatase 1, regulatory subunit 3D 2.19177
CALML5 calmodulin-like 5 2.16505
RELN reelin 2.15635
SYBU syntabulin (syntaxin-interacting) 2.13805
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.12485
FBXO3 F-box protein 3 2.1164
PTP4A3 protein tyrosine phosphatase type IVA, member 3 2.11345
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 2.1125
ASL argininosuccinate lyase 2.11155
TBX4 T-box 4 2.1081
KPLCE KPRP N-terminal and LCE C-terminal like protein 2.097
TCTN1 tectonic family member 1 2.09615
BIN2 bridging integrator 2 2.0907
TCHH trichohyalin 2.0853
EMC9 ER membrane protein complex subunit 9 2.08105
MINDY1 MINDY lysine 48 deubiquitinase 1 2.0802
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 2.0736
MIA melanoma inhibitory activity 2.0627
ALDOC aldolase C, fructose-bisphosphate 2.0621
HSPA2 heat shock 70kDa protein 2 2.05745
TXNRD3 thioredoxin reductase 3 2.04865
TCIM transcriptional and immune response regulator 2.0427
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein 2.04265
TYRP1 tyrosinase-related protein 1 2.04125
SNX16 sorting nexin 16 2.04005
LDHC lactate dehydrogenase C 2.03175
AQP9 aquaporin 9 2.02855
IL2RB interleukin 2 receptor, beta 2.00595
SLC25A40 solute carrier family 25, member 40 2.00445
EGLN1 egl-9 family hypoxia-inducible factor 1 2.004

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -5.4583
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.3652
KIF14 kinesin family member 14 -5.15195
YME1L1 YME1-like 1 ATPase -4.46308
UFM1 ubiquitin-fold modifier 1 -4.4254
OXA1L oxidase (cytochrome c) assembly 1-like -4.3719
CD58 CD58 molecule -4.12298
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.50973
TKT transketolase -3.15125
CD81 CD81 molecule -3.1067
VTI1B vesicle transport through interaction with t-SNAREs 1B -3.08295
GSDME gasdermin E -2.91795
RBM34 RNA binding motif protein 34 -2.856
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.8335
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.75975
TNPO3 transportin 3 -2.63408
COPS5 COP9 signalosome subunit 5 -2.5617
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -2.5533
GDF15 growth differentiation factor 15 -2.5273
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.5209
SMC1A structural maintenance of chromosomes 1A -2.47545
HSPA1A heat shock 70kDa protein 1A -2.45455
SYF2 SYF2 pre-mRNA-splicing factor -2.4413
TMEM243 transmembrane protein 243, mitochondrial -2.41995
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -2.4068
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -2.2651
WASHC4 WASH complex subunit 4 -2.2578
NGRN neugrin, neurite outgrowth associated -2.2255
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -2.2196
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) -2.2186
SERINC1 serine incorporator 1 -2.1949
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.14915
PFN1 profilin 1 -2.1297
SCRIB scribbled planar cell polarity protein -2.11465
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -2.11415
ZFYVE26 zinc finger, FYVE domain containing 26 -2.1051
KDM5C lysine (K)-specific demethylase 5C -2.1012
SQSTM1 sequestosome 1 -2.08817
CDK18 cyclin-dependent kinase 18 -2.07945
RBM15B RNA binding motif protein 15B -2.07515
STK25 serine/threonine kinase 25 -2.0665
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -2.0621
ARHGAP17 Rho GTPase activating protein 17 -2.0416
SLC4A2 solute carrier family 4 (anion exchanger), member 2 -2.02515
NME3 NME/NM23 nucleoside diphosphate kinase 3 -2.00825
RBBP5 retinoblastoma binding protein 5 -2.0071