CRCGN017_MCF10A.WT.HP_24H:G22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-(methylnitrosamino)-1-(3-pyri?dyl)-1-butanol 98.14 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:G22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZW10 zw10 kinetochore protein 5.1223
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.04205
C2CD2 C2 calcium-dependent domain containing 2 4.71535
BAMBI BMP and activin membrane-bound inhibitor 2.64775
CCNF cyclin F 2.41188
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.3264
CEP57 centrosomal protein 57kDa 2.23182
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 2.19885
TPD52L2 tumor protein D52-like 2 2.00895

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -10.0
KRT14 keratin 14, type I -5.0
PANK2 pantothenate kinase 2 -3.2652
TMEM230 transmembrane protein 230 -3.22635
SNX5 sorting nexin 5 -2.9605
WASHC4 WASH complex subunit 4 -2.79443
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.77865
MAVS mitochondrial antiviral signaling protein -2.7433
ACAA1 acetyl-CoA acyltransferase 1 -2.73695
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.6042
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.54985
AZU1 azurocidin 1 -2.523
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.51773
NSFL1C NSFL1 (p97) cofactor (p47) -2.51507
HSPA1A heat shock 70kDa protein 1A -2.43335
XPO7 exportin 7 -2.3847
CENPB centromere protein B, 80kDa -2.31325
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.2931
MPO myeloperoxidase -2.27555
ATRN attractin -2.24605
L2HGDH L-2-hydroxyglutarate dehydrogenase -2.23505
DDRGK1 DDRGK domain containing 1 -2.1883
CREG1 cellular repressor of E1A-stimulated genes 1 -2.13995
MCM6 minichromosome maintenance complex component 6 -2.1127
ULBP2 UL16 binding protein 2 -2.09795
LSM1 LSM1, U6 small nuclear RNA associated -2.0936
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) -2.0557
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.04802
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.02885
SPRR3 small proline-rich protein 3 -2.003