CRCGN017_MCF10A.WT.HP_24H:G23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-(methylnitrosamino)-1-(3-pyri?dyl)-1-butanol 32.71 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

235 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:G23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
MAMLD1 mastermind-like domain containing 1 10.0
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 8.77885
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 7.59595
TIAM1 T-cell lymphoma invasion and metastasis 1 6.21935
ACAA1 acetyl-CoA acyltransferase 1 6.1268
OLFML2B olfactomedin-like 2B 4.4113
COMP cartilage oligomeric matrix protein 3.5006
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 3.4728
PLS1 plastin 1 3.31
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 3.2793
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.1789
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 3.0097
TRAPPC4 trafficking protein particle complex 4 2.88055
ETNK1 ethanolamine kinase 1 2.82415
HOXC10 homeobox C10 2.7895
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.7691
SYT2 synaptotagmin II 2.7684
FXYD2 FXYD domain containing ion transport regulator 2 2.75765
SPOUT1 SPOUT domain containing methyltransferase 1 2.7287
ENTR1 endosome associated trafficking regulator 1 2.7252
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 2.676
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.66305
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 2.6326
GFRA1 GDNF family receptor alpha 1 2.6202
NKX2-8 NK2 homeobox 8 2.6202
PDZK1 PDZ domain containing 1 2.6171
COQ8A coenzyme Q8A 2.5797
TROAP trophinin associated protein 2.5625
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) 2.5242
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 2.502
HMOX2 heme oxygenase 2 2.4671
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.4621
KCNK2 potassium channel, two pore domain subfamily K, member 2 2.4618
ISOC2 isochorismatase domain containing 2 2.453
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 2.4413
RPS25 ribosomal protein S25 2.4386
NR1H3 nuclear receptor subfamily 1, group H, member 3 2.4084
PYDC1 PYD (pyrin domain) containing 1 2.3998
KRT76 keratin 76, type II 2.3858
FAM246A family with sequence similarity 246 member A 2.3787
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) 2.3723
RTRAF RNA transcription, translation and transport factor 2.3652
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 2.3556
CRNN cornulin 2.3361
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 2.3261
GPC4 glypican 4 2.32165
GRB14 growth factor receptor-bound protein 14 2.3104
SYNGAP1 synaptic Ras GTPase activating protein 1 2.29295
EDN1 endothelin 1 2.2777
NR2F2 nuclear receptor subfamily 2, group F, member 2 2.2633
LBHD1 LBH domain containing 1 2.2569
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.2486
STK26 serine/threonine protein kinase 26 2.2418
MYF6 myogenic factor 6 (herculin) 2.2376
CXCL12 chemokine (C-X-C motif) ligand 12 2.23585
PLSCR3 phospholipid scramblase 3 2.2296
TWNK twinkle mtDNA helicase 2.222
TMPRSS11E transmembrane protease, serine 11E 2.2213
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 2.2135
SFT2D2 SFT2 domain containing 2 2.2067
TMEM131L transmembrane 131 like 2.2058
ACE2 angiotensin I converting enzyme 2 2.20155
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 2.20085
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 2.1974
AOC1 amine oxidase, copper containing 1 2.1904
HMGN1 high mobility group nucleosome binding domain 1 2.1742
UBAC1 UBA domain containing 1 2.172
SURF2 surfeit 2 2.1653
NHP2 NHP2 ribonucleoprotein 2.1628
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.1614
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.1458
C4A complement component 4A (Rodgers blood group) 2.14525
PDE11A phosphodiesterase 11A 2.1416
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 2.1382
GTF3A general transcription factor IIIA 2.13775
GLS2 glutaminase 2 (liver, mitochondrial) 2.135
MFAP2 microfibrillar-associated protein 2 2.1252
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 2.124
MDFI MyoD family inhibitor 2.1236
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 2.1106
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 2.10785
SFRP5 secreted frizzled-related protein 5 2.1027
RIDA reactive intermediate imine deaminase A homolog 2.1016
MYOZ1 myozenin 1 2.1011
TKTL1 transketolase-like 1 2.09965
ADAM12 ADAM metallopeptidase domain 12 2.0861
FXYD6-FXYD2 FXYD6-FXYD2 readthrough 2.0796
RECQL4 RecQ protein-like 4 2.0744
CDA cytidine deaminase 2.066
OSMR oncostatin M receptor 2.0573
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 2.0563
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.0517
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 2.0443
TGM2 transglutaminase 2 2.03895
ACSM2A acyl-CoA synthetase medium-chain family member 2A 2.0361
RABIF RAB interacting factor 2.02715
PMPCA peptidase (mitochondrial processing) alpha 2.0184
PXMP2 peroxisomal membrane protein 2, 22kDa 2.0154
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 2.0137
NOP2 NOP2 nucleolar protein 2.0074
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 2.0058
NTAQ1 N-terminal glutamine amidase 1 2.0052

decreased expression

Symbol Name Standardized Value
ACOT9 acyl-CoA thioesterase 9 -10.0
PARP2 poly (ADP-ribose) polymerase 2 -9.6006
NR2F6 nuclear receptor subfamily 2, group F, member 6 -6.2765
ANXA2 annexin A2 -5.5903
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -5.32027
GDF15 growth differentiation factor 15 -4.4469
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.4429
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -4.2138
METTL17 methyltransferase like 17 -4.1104
OSGEP O-sialoglycoprotein endopeptidase -3.9804
OCEL1 occludin/ELL domain containing 1 -3.6542
LOC127933115 uncharacterized LOC127933115 -3.6014
S100A8 S100 calcium binding protein A8 -3.4783
FOCAD focadhesin -3.2718
IFNGR1 interferon gamma receptor 1 -3.11115
RBBP7 retinoblastoma binding protein 7 -3.0671
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -3.03775
FCGBP Fc fragment of IgG binding protein -2.9944
FKTN fukutin -2.9084
PNPLA4 patatin-like phospholipase domain containing 4 -2.83475
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -2.8191
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -2.7821
RFXANK regulatory factor X-associated ankyrin-containing protein -2.7349
NME7 NME/NM23 family member 7 -2.7196
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 -2.6903
PIGK phosphatidylinositol glycan anchor biosynthesis, class K -2.6831
TEAD3 TEA domain family member 3 -2.6677
TPO thyroid peroxidase -2.6471
MSLN mesothelin -2.6098
WWC3 WWC family member 3 -2.5938
PUDP pseudouridine 5'-phosphatase -2.5894
HOXA1 homeobox A1 -2.5716
GBP2 guanylate binding protein 2, interferon-inducible -2.5705
KIF16B kinesin family member 16B -2.5607
SPI1 Spi-1 proto-oncogene -2.5569
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.55526
HCCS holocytochrome c synthase -2.5393
CXCL14 chemokine (C-X-C motif) ligand 14 -2.5392
LRRC41 leucine rich repeat containing 41 -2.53585
CPB1 carboxypeptidase B1 (tissue) -2.5346
KLHL26 kelch-like family member 26 -2.5111
COA7 cytochrome c oxidase assembly factor 7 (putative) -2.5022
COLGALT1 collagen beta(1-O)galactosyltransferase 1 -2.4982
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -2.4721
SUGP2 SURP and G patch domain containing 2 -2.46342
LIMS1 LIM and senescent cell antigen-like domains 1 -2.4633
APOO apolipoprotein O -2.4564
TBX3 T-box 3 -2.4543
LMO3 LIM domain only 3 (rhombotin-like 2) -2.4524
BCL2L2 BCL2-like 2 -2.4285
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 -2.4246
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -2.4195
F3 coagulation factor III (thromboplastin, tissue factor) -2.4171
ZNF282 zinc finger protein 282 -2.4152
CRYZL1 crystallin, zeta (quinone reductase)-like 1 -2.4069
DENND2A DENN/MADD domain containing 2A -2.3788
FPGT fucose-1-phosphate guanylyltransferase -2.3739
CTPS2 CTP synthase 2 -2.3694
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -2.3669
XPA xeroderma pigmentosum, complementation group A -2.3604
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -2.3563
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -2.3548
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 -2.3443
ACSL5 acyl-CoA synthetase long-chain family member 5 -2.3411
BICRAL BICRA like chromatin remodeling complex associated protein -2.3225
MSL3 male-specific lethal 3 homolog (Drosophila) -2.31005
CHD8 chromodomain helicase DNA binding protein 8 -2.3092
RGPD1 RANBP2-like and GRIP domain containing 1 -2.309
MMD monocyte to macrophage differentiation-associated -2.3072
CCDC25 coiled-coil domain containing 25 -2.3047
PRDX4 peroxiredoxin 4 -2.3003
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 -2.2777
GMPR2 guanosine monophosphate reductase 2 -2.2751
PLPPR4 phospholipid phosphatase related 4 -2.2741
ZBTB38 zinc finger and BTB domain containing 38 -2.2693
TXNDC15 thioredoxin domain containing 15 -2.2248
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 -2.2246
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 -2.2224
SQSTM1 sequestosome 1 -2.2213
CXCL3 chemokine (C-X-C motif) ligand 3 -2.2137
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides -2.2071
SPAG16 sperm associated antigen 16 -2.2007
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 -2.1942
USP11 ubiquitin specific peptidase 11 -2.1836
TFE3 transcription factor binding to IGHM enhancer 3 -2.18185
MYOC myocilin, trabecular meshwork inducible glucocorticoid response -2.1669
DZANK1 double zinc ribbon and ankyrin repeat domains 1 -2.1662
VASP vasodilator-stimulated phosphoprotein -2.1593
NBEA neurobeachin -2.1573
GBP1 guanylate binding protein 1, interferon-inducible -2.15215
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -2.1487
SERGEF secretion regulating guanine nucleotide exchange factor -2.1329
ANXA8L1 annexin A8-like 1 -2.1325
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 -2.1291
SPATS2 spermatogenesis associated, serine-rich 2 -2.1276
AHCYL1 adenosylhomocysteinase-like 1 -2.1241
IL11RA interleukin 11 receptor, alpha -2.1195
PRKCB protein kinase C, beta -2.11675
PF4 platelet factor 4 -2.1161
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -2.1048
NAIP NLR family, apoptosis inhibitory protein -2.1047
DDHD2 DDHD domain containing 2 -2.0907
DENND2B DENN domain containing 2B -2.0905
TKFC triokinase/FMN cyclase -2.0873
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -2.0868
CHGB chromogranin B -2.0861
EMC9 ER membrane protein complex subunit 9 -2.0745
PLTP phospholipid transfer protein -2.0736
DUSP8 dual specificity phosphatase 8 -2.0716
PDE8B phosphodiesterase 8B -2.0711
MTRF1 mitochondrial translational release factor 1 -2.0633
CCL5 chemokine (C-C motif) ligand 5 -2.05865
HLTF helicase-like transcription factor -2.0583
SLC4A2 solute carrier family 4 (anion exchanger), member 2 -2.0548
CHL1 cell adhesion molecule L1-like -2.0516
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.0514
GBE1 glucan (1,4-alpha-), branching enzyme 1 -2.0362
PANX1 pannexin 1 -2.0357
PID1 phosphotyrosine interaction domain containing 1 -2.0328
LAMC1 laminin, gamma 1 (formerly LAMB2) -2.03255
DELE1 DAP3 binding cell death enhancer 1 -2.02705
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) -2.02345
USP33 ubiquitin specific peptidase 33 -2.023
CLEC5A C-type lectin domain family 5, member A -2.0214
POLI polymerase (DNA directed) iota -2.0202
FLNC filamin C, gamma -2.0163
TRIM21 tripartite motif containing 21 -2.0146
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -2.01443
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.01277
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -2.0076
SERF1A small EDRK-rich factor 1A (telomeric) -2.0064
LAMA5 laminin, alpha 5 -2.0046