CRCGN017_MCF10A.WT.HP_24H:G24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-(methylnitrosamino)-1-(3-pyri?dyl)-1-butanol 10.9 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:G24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NANOS3 nanos homolog 3 (Drosophila) 5.4617
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.0933
SNAP25 synaptosomal-associated protein, 25kDa 4.9469
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 4.69865
CNRIP1 cannabinoid receptor interacting protein 1 4.66275
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 4.2882
E2F2 E2F transcription factor 2 3.723
ACAA1 acetyl-CoA acyltransferase 1 3.09295
IGHMBP2 immunoglobulin mu binding protein 2 3.02848
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.9011
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.794
LHX5 LIM homeobox 5 2.5492
ATXN7L1 ataxin 7-like 1 2.53625
WDR18 WD repeat domain 18 2.37885
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.3767
PRDM8 PR domain containing 8 2.3345
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.32275
HCRT hypocretin (orexin) neuropeptide precursor 2.31845
VCX3A variable charge, X-linked 3A 2.29367
IGLL1 immunoglobulin lambda-like polypeptide 1 2.27985
GRIA4 glutamate receptor, ionotropic, AMPA 4 2.2644
EVC Ellis van Creveld protein 2.26435
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 2.2534
NID2 nidogen 2 (osteonidogen) 2.25135
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 2.2459
NKX2-8 NK2 homeobox 8 2.20515
ICAM2 intercellular adhesion molecule 2 2.20188
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 2.1985
ZFPM1 zinc finger protein, FOG family member 1 2.1844
FOXD2 forkhead box D2 2.1771
TRAPPC6A trafficking protein particle complex 6A 2.17515
POLL polymerase (DNA directed), lambda 2.15685
LGSN lengsin, lens protein with glutamine synthetase domain 2.1528
NAP1L2 nucleosome assembly protein 1-like 2 2.15195
UPK3A uroplakin 3A 2.1277
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 2.1147
GCAT glycine C-acetyltransferase 2.10133
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit 2.08822
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.0687
VAX2 ventral anterior homeobox 2 2.06595
SHH sonic hedgehog 2.0463
TRIM11 tripartite motif containing 11 2.0385
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2.0383
CADM4 cell adhesion molecule 4 2.03678
GRTP1 growth hormone regulated TBC protein 1 2.03035
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.0282
ABHD14A abhydrolase domain containing 14A 2.0177
MMP15 matrix metallopeptidase 15 (membrane-inserted) 2.0175
CDH20 cadherin 20, type 2 2.0045

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -4.8324
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.75445
YME1L1 YME1-like 1 ATPase -4.60187
CD44 CD44 molecule (Indian blood group) -4.21091
COPS7A COP9 signalosome subunit 7A -4.1909
ARPP19 cAMP-regulated phosphoprotein, 19kDa -3.73632
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.5232
SNX7 sorting nexin 7 -2.8866
TOMM70 translocase of outer mitochondrial membrane 70 -2.6717
MSN moesin -2.5106
MAPK6 mitogen-activated protein kinase 6 -2.4585
WAC WW domain containing adaptor with coiled-coil -2.41538
HMBOX1 homeobox containing 1 -2.25965
ABI1 abl-interactor 1 -2.21265
AMZ2 archaelysin family metallopeptidase 2 -2.1898
YAP1 Yes-associated protein 1 -2.1154
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide -2.0919
TLCD3A TLC domain containing 3A -2.08425
LOC128031832 uncharacterized LOC128031832 -2.0414