CRCGN017_MCF10A.WT.HP_24H:H02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-nitrosopiperidine 33.49 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

36 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:H02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.83851
CNPY3 canopy FGF signaling regulator 3 4.55419
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.71215
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.27993
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.73699
GIMAP6 GTPase, IMAP family member 6 2.18162
PECAM1 platelet/endothelial cell adhesion molecule 1 2.16938
GRAPL GRB2-related adaptor protein-like 2.16882
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.16863
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.16588
CCL2 chemokine (C-C motif) ligand 2 2.12903
TENT4A terminal nucleotidyltransferase 4A 2.10336
GPR65 G protein-coupled receptor 65 2.08269
BNC1 basonuclin 1 2.07635
LPAR6 lysophosphatidic acid receptor 6 2.00522

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -7.66345
VAT1 vesicle amine transport 1 -5.53449
ZDHHC6 zinc finger, DHHC-type containing 6 -4.99289
CCNB1 cyclin B1 -4.96539
TXNDC9 thioredoxin domain containing 9 -4.81642
ENOPH1 enolase-phosphatase 1 -4.55633
CD58 CD58 molecule -3.90382
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.8595
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.43268
CANT1 calcium activated nucleotidase 1 -3.36071
SNX7 sorting nexin 7 -2.65419
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.38858
TOMM34 translocase of outer mitochondrial membrane 34 -2.1881
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -2.16079
TGIF1 TGFB-induced factor homeobox 1 -2.13873
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -2.1273
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.09845
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -2.0882
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.06612
KIN Kin17 DNA and RNA binding protein -2.04747
NFS1 NFS1 cysteine desulfurase -2.0078