CRCGN017_MCF10A.WT.HP_24H:H11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetracycline 33.82 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

268 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:H11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 7.4647
PYCR1 pyrroline-5-carboxylate reductase 1 7.1643
AARS1 alanyl-tRNA synthetase 1 6.3106
PSAT1 phosphoserine aminotransferase 1 6.04295
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 5.7765
PHGDH phosphoglycerate dehydrogenase 5.59562
GARS1 glycyl-tRNA synthetase 1 5.06815
C2CD2 C2 calcium-dependent domain containing 2 4.9547
SPAG4 sperm associated antigen 4 4.91085
LOXL1 lysyl oxidase-like 1 4.7284
YARS1 tyrosyl-tRNA synthetase 1 4.53565
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 4.4586
EPRS1 glutamyl-prolyl-tRNA synthetase 1 4.39405
TRIB3 tribbles pseudokinase 3 4.3805
GLRX glutaredoxin (thioltransferase) 4.26697
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 4.1972
TARS1 threonyl-tRNA synthetase 1 4.14175
TXNRD1 thioredoxin reductase 1 4.07145
XPOT exportin, tRNA 4.0692
GFPT1 glutamine--fructose-6-phosphate transaminase 1 3.97018
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 3.8417
ATF4 activating transcription factor 4 3.8097
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 3.69265
NUCB2 nucleobindin 2 3.59845
FYN FYN proto-oncogene, Src family tyrosine kinase 3.57325
ASNS asparagine synthetase (glutamine-hydrolyzing) 3.4835
NARS1 asparaginyl-tRNA synthetase 1 3.4744
AGR2 anterior gradient 2 3.4643
CHMP4B charged multivesicular body protein 4B 3.4578
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 3.34965
MAPK9 mitogen-activated protein kinase 9 3.34613
MARS1 methionyl-tRNA synthetase 1 3.2809
VSIG2 V-set and immunoglobulin domain containing 2 3.11735
FCHO1 FCH domain only 1 3.025
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 3.00803
ECH1 enoyl CoA hydratase 1, peroxisomal 2.9899
CARS1 cysteinyl-tRNA synthetase 1 2.984
IARS1 isoleucyl-tRNA synthetase 1 2.83955
CALCOCO2 calcium binding and coiled-coil domain 2 2.8384
TPD52L2 tumor protein D52-like 2 2.8238
KDM5D lysine (K)-specific demethylase 5D 2.79895
TBC1D16 TBC1 domain family, member 16 2.75275
NLRP4 NLR family, pyrin domain containing 4 2.7173
DHDDS dehydrodolichyl diphosphate synthase 2.71695
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.7013
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 2.69275
CTSL cathepsin L 2.69225
SLC31A1 solute carrier family 31 (copper transporter), member 1 2.63765
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2.6125
OARD1 O-acyl-ADP-ribose deacylase 1 2.5927
GSTZ1 glutathione S-transferase zeta 1 2.5859
LOC128125814 uncharacterized LOC128125814 2.57775
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.56815
PCCB propionyl CoA carboxylase, beta polypeptide 2.56695
CREG1 cellular repressor of E1A-stimulated genes 1 2.5657
ERP29 endoplasmic reticulum protein 29 2.5425
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog 2.5369
LETMD1 LETM1 domain containing 1 2.5309
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.5241
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 2.52405
FKBP11 FK506 binding protein 11, 19 kDa 2.47612
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.43615
TM9SF3 transmembrane 9 superfamily member 3 2.425
STC2 stanniocalcin 2 2.42173
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 2.4034
ZCCHC8 zinc finger, CCHC domain containing 8 2.39885
TWF2 twinfilin actin binding protein 2 2.3885
MCUR1 mitochondrial calcium uniporter regulator 1 2.37155
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 2.36465
PROSER1 proline and serine rich 1 2.35515
HAX1 HCLS1 associated protein X-1 2.35455
JARID2 jumonji, AT rich interactive domain 2 2.34347
MACROD1 MACRO domain containing 1 2.3434
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.34078
LCMT1 leucine carboxyl methyltransferase 1 2.33615
LOC102724560 cystathionine beta-synthase 2.3221
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.31825
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.31335
LIAS lipoic acid synthetase 2.3075
CEP85 centrosomal protein 85kDa 2.3054
GRB10 growth factor receptor-bound protein 10 2.30405
GOLGA3 golgin A3 2.3035
CAMTA2 calmodulin binding transcription activator 2 2.2915
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.28717
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.27765
HOOK1 hook microtubule-tethering protein 1 2.259
NUPR1 nuclear protein, transcriptional regulator, 1 2.25625
MTIF2 mitochondrial translational initiation factor 2 2.24085
RUFY1 RUN and FYVE domain containing 1 2.2316
SIL1 SIL1 nucleotide exchange factor 2.21275
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 2.18895
BLVRB biliverdin reductase B 2.1708
NAT9 N-acetyltransferase 9 (GCN5-related, putative) 2.16085
WASF2 WAS protein family, member 2 2.15865
RBM15B RNA binding motif protein 15B 2.1391
CREB3L2 cAMP responsive element binding protein 3-like 2 2.1317
RIOX2 ribosomal oxygenase 2 2.1281
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 2.1163
IFITM1 interferon induced transmembrane protein 1 2.11247
MKRN2 makorin ring finger protein 2 2.1003
SYF2 SYF2 pre-mRNA-splicing factor 2.0985
OXCT1 3-oxoacid CoA transferase 1 2.0887
CCNA1 cyclin A1 2.08195
CCS copper chaperone for superoxide dismutase 2.0745
SNX24 sorting nexin 24 2.07415
ENOSF1 enolase superfamily member 1 2.06866
TFB1M transcription factor B1, mitochondrial 2.05635
SSR4 signal sequence receptor, delta 2.03135
TENT5C terminal nucleotidyltransferase 5C 2.02195
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.00393
GOLT1A golgi transport 1A 2.00155

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -6.13735
CCNB1 cyclin B1 -5.7413
ADI1 acireductone dioxygenase 1 -5.2391
PUF60 poly-U binding splicing factor 60KDa -5.0
ARID4B AT rich interactive domain 4B (RBP1-like) -4.59265
ACOT9 acyl-CoA thioesterase 9 -4.4682
SNX7 sorting nexin 7 -4.1942
HOXA5 homeobox A5 -4.19015
S100A8 S100 calcium binding protein A8 -4.0193
INSIG1 insulin induced gene 1 -3.54765
FHL5 four and a half LIM domains 5 -3.35595
CD81 CD81 molecule -3.2977
SPRED2 sprouty-related, EVH1 domain containing 2 -3.21095
DCK deoxycytidine kinase -3.1964
GINS3 GINS complex subunit 3 (Psf3 homolog) -3.17295
FAIM Fas apoptotic inhibitory molecule -3.06105
JAG2 jagged 2 -3.03162
SGK1 serum/glucocorticoid regulated kinase 1 -3.02305
OGN osteoglycin -2.983
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -2.96305
KRT14 keratin 14, type I -2.9121
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.89225
CRYZ crystallin, zeta (quinone reductase) -2.8725
KRT13 keratin 13, type I -2.8653
PTK2 protein tyrosine kinase 2 -2.82562
NCS1 neuronal calcium sensor 1 -2.80495
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.79653
GMNN geminin, DNA replication inhibitor -2.78592
HSPA12A heat shock 70kDa protein 12A -2.74375
MATN2 matrilin 2 -2.7359
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -2.71325
FXYD1 FXYD domain containing ion transport regulator 1 -2.70445
GJD3 gap junction protein, delta 3, 31.9kDa -2.68705
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 -2.6797
CCNL1 cyclin L1 -2.6788
UPK3B uroplakin 3B -2.66955
RASL12 RAS-like, family 12 -2.6295
RRAGB Ras-related GTP binding B -2.6112
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) -2.60835
KDM6A lysine (K)-specific demethylase 6A -2.60403
ANGPTL7 angiopoietin-like 7 -2.55795
SMC1A structural maintenance of chromosomes 1A -2.55418
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.5505
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -2.5372
ELAVL4 ELAV like neuron-specific RNA binding protein 4 -2.52365
HSPB1 heat shock 27kDa protein 1 -2.51905
ZFP91 ZFP91 zinc finger protein -2.4895
ZNF721 zinc finger protein 721 -2.4723
PYDC1 PYD (pyrin domain) containing 1 -2.4634
ELOVL6 ELOVL fatty acid elongase 6 -2.46165
NDRG4 NDRG family member 4 -2.456
TUBG2 tubulin, gamma 2 -2.4548
SMNDC1 survival motor neuron domain containing 1 -2.44625
HYDIN HYDIN, axonemal central pair apparatus protein -2.4316
FXYD6-FXYD2 FXYD6-FXYD2 readthrough -2.42295
PLN phospholamban -2.41172
MORC3 MORC family CW-type zinc finger 3 -2.4004
ANKRD6 ankyrin repeat domain 6 -2.3935
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.37125
CALM3 calmodulin 3 (phosphorylase kinase, delta) -2.34737
ASCL1 achaete-scute family bHLH transcription factor 1 -2.34675
CAMTA1 calmodulin binding transcription activator 1 -2.33585
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.33185
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal -2.32943
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) -2.32445
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.30435
ZNF480 zinc finger protein 480 -2.301
SNRPA1 small nuclear ribonucleoprotein polypeptide A' -2.2997
TRAPPC13 trafficking protein particle complex 13 -2.2995
SCRIB scribbled planar cell polarity protein -2.28885
HOXD9 homeobox D9 -2.28055
PRR15L proline rich 15-like -2.28015
EMP2 epithelial membrane protein 2 -2.27505
FMNL3 formin-like 3 -2.2736
CD93 CD93 molecule -2.27292
CHAD chondroadherin -2.27145
EMCN endomucin -2.26995
UNC5C unc-5 homolog C (C. elegans) -2.26705
TUBB6 tubulin, beta 6 class V -2.2566
TRIM21 tripartite motif containing 21 -2.2553
RERGL RERG/RAS-like -2.25365
FAM163A family with sequence similarity 163, member A -2.2527
PSRC1 proline/serine-rich coiled-coil 1 -2.24885
CSK c-src tyrosine kinase -2.2418
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.2398
CALCRL calcitonin receptor-like -2.2375
SEC24B SEC24 family member B -2.21605
WNT7B wingless-type MMTV integration site family, member 7B -2.20105
ZNF143 zinc finger protein 143 -2.1968
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.18615
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) -2.1818
HLX H2.0-like homeobox -2.1792
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.17725
ZNF324B zinc finger protein 324B -2.1725
GSPT2 G1 to S phase transition 2 -2.1693
ZNF107 zinc finger protein 107 -2.1544
CDK1 cyclin-dependent kinase 1 -2.14063
PPP1R12B protein phosphatase 1, regulatory subunit 12B -2.13783
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 -2.1376
MYH7B myosin, heavy chain 7B, cardiac muscle, beta -2.13685
RPGRIP1L RPGRIP1-like -2.13595
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 -2.1337
PGF placental growth factor -2.13295
DYSF dysferlin -2.1307
DNAH3 dynein, axonemal, heavy chain 3 -2.1274
STMN1 stathmin 1 -2.12635
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.1203
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -2.11893
BPHL biphenyl hydrolase-like (serine hydrolase) -2.11755
TEF thyrotrophic embryonic factor -2.1079
ANGPT2 angiopoietin 2 -2.10458
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.10425
SERF1A small EDRK-rich factor 1A (telomeric) -2.10225
CASQ2 calsequestrin 2 (cardiac muscle) -2.10025
ASB9 ankyrin repeat and SOCS box containing 9 -2.0956
SNN stannin -2.0928
CCN3 cellular communication network factor 3 -2.08857
RRH retinal pigment epithelium-derived rhodopsin homolog -2.0838
LINS1 lines homolog 1 -2.07985
SCHIP1 schwannomin interacting protein 1 -2.07985
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -2.0792
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.07877
ADAMTSL2 ADAMTS-like 2 -2.07845
IL18 interleukin 18 -2.0773
CLEC1A C-type lectin domain family 1, member A -2.07655
VAX2 ventral anterior homeobox 2 -2.0758
DENND3 DENN/MADD domain containing 3 -2.07363
ZNF557 zinc finger protein 557 -2.0734
CYCS cytochrome c, somatic -2.06985
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -2.0697
TMLHE trimethyllysine hydroxylase, epsilon -2.0612
NCAM2 neural cell adhesion molecule 2 -2.0596
MAB21L1 mab-21-like 1 (C. elegans) -2.05575
MSANTD3-TMEFF1 MSANTD3-TMEFF1 readthrough -2.0554
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) -2.05025
ALOX5AP arachidonate 5-lipoxygenase-activating protein -2.04905
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 -2.04785
MARCKS myristoylated alanine-rich protein kinase C substrate -2.04473
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 -2.0382
TICAM1 toll-like receptor adaptor molecule 1 -2.0337
HRC histidine rich calcium binding protein -2.03345
GATA2 GATA binding protein 2 -2.0328
ERCC6L excision repair cross-complementation group 6-like -2.0301
PTBP2 polypyrimidine tract binding protein 2 -2.02865
TLR1 toll-like receptor 1 -2.0248
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) -2.02287
CDH5 cadherin 5, type 2 (vascular endothelium) -2.0197
MCPH1 microcephalin 1 -2.01685
AP4M1 adaptor-related protein complex 4, mu 1 subunit -2.01605
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 -2.0129
CBR3 carbonyl reductase 3 -2.0126
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 -2.01035
MAB21L2 mab-21-like 2 (C. elegans) -2.0084
PTHLH parathyroid hormone-like hormone -2.00813
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -2.0052
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -2.00325
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -2.0032