CRCGN017_MCF10A.WT.HP_24H:H12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetracycline 11.27 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

144 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:H12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 6.65185
PHGDH phosphoglycerate dehydrogenase 5.56785
AARS1 alanyl-tRNA synthetase 1 5.4601
CCP110 centriolar coiled coil protein 110kDa 5.3245
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 5.30115
ABHD4 abhydrolase domain containing 4 4.98065
PSAT1 phosphoserine aminotransferase 1 4.6682
PYCR1 pyrroline-5-carboxylate reductase 1 4.595
SNAP25 synaptosomal-associated protein, 25kDa 4.57827
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.26875
RBKS ribokinase 3.68817
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 3.46475
WIF1 WNT inhibitory factor 1 3.4414
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.4061
YARS1 tyrosyl-tRNA synthetase 1 3.3453
ASNS asparagine synthetase (glutamine-hydrolyzing) 3.2195
EPRS1 glutamyl-prolyl-tRNA synthetase 1 3.1899
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 3.17275
GARS1 glycyl-tRNA synthetase 1 3.14555
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 3.08306
XPOT exportin, tRNA 2.76155
ATF4 activating transcription factor 4 2.75505
MMP1 matrix metallopeptidase 1 2.72337
LOXL1 lysyl oxidase-like 1 2.69705
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.6737
NSG2 neuronal vesicle trafficking associated 2 2.6659
SMC6 structural maintenance of chromosomes 6 2.66185
LOC122526780 uncharacterized LOC122526780 2.5324
HYOU1 hypoxia up-regulated 1 2.4944
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.4768
SYNE2 spectrin repeat containing, nuclear envelope 2 2.435
OXCT1 3-oxoacid CoA transferase 1 2.30815
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.27765
FKBP11 FK506 binding protein 11, 19 kDa 2.2549
P3H3 prolyl 3-hydroxylase 3 2.2502
NPY neuropeptide Y 2.24895
ZMIZ1 zinc finger, MIZ-type containing 1 2.2167
AHCYL1 adenosylhomocysteinase-like 1 2.21025
TARS1 threonyl-tRNA synthetase 1 2.2021
MID1IP1 MID1 interacting protein 1 2.188
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 2.17625
CLEC11A C-type lectin domain family 11, member A 2.17548
CARS1 cysteinyl-tRNA synthetase 1 2.16657
P3H1 prolyl 3-hydroxylase 1 2.15755
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.13645
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.12565
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.1236
MARS1 methionyl-tRNA synthetase 1 2.12272
MBNL2 muscleblind-like splicing regulator 2 2.10913
XPC xeroderma pigmentosum, complementation group C 2.07775
SLC38A10 solute carrier family 38, member 10 2.07285
TXNDC15 thioredoxin domain containing 15 2.07025
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.0475

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -5.4621
SLC35F2 solute carrier family 35, member F2 -5.23945
TXNDC9 thioredoxin domain containing 9 -4.84695
PRPF4 pre-mRNA processing factor 4 -4.8091
HMG20B high mobility group 20B -4.61623
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -4.01667
SGK1 serum/glucocorticoid regulated kinase 1 -4.0075
CLTB clathrin, light chain B -3.84722
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -3.4781
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.29395
MSMO1 methylsterol monooxygenase 1 -2.97605
CLIC3 chloride intracellular channel 3 -2.92815
MYOM2 myomesin 2 -2.66435
CYREN cell cycle regulator of NHEJ -2.5894
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -2.523
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.49
FKBP15 FK506 binding protein 15, 133kDa -2.48732
PDCL phosducin-like -2.46585
UBAC1 UBA domain containing 1 -2.44795
ZNF721 zinc finger protein 721 -2.4423
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) -2.43115
TESPA1 thymocyte expressed, positive selection associated 1 -2.40335
CLIC2 chloride intracellular channel 2 -2.3963
TRDN triadin -2.3783
ZNF557 zinc finger protein 557 -2.36865
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.33875
TOR1B torsin family 1, member B (torsin B) -2.3232
SLC44A1 solute carrier family 44 (choline transporter), member 1 -2.32305
CAND2 cullin-associated and neddylation-dissociated 2 (putative) -2.31205
TNNT3 troponin T type 3 (skeletal, fast) -2.3101
POPDC2 popeye domain containing 2 -2.30985
GPRC5A G protein-coupled receptor, class C, group 5, member A -2.29273
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.28555
SNX7 sorting nexin 7 -2.28525
SPIN2B spindlin family, member 2B -2.27775
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 -2.26445
LYPD3 LY6/PLAUR domain containing 3 -2.2579
CCNE1 cyclin E1 -2.2565
EGLN3 egl-9 family hypoxia-inducible factor 3 -2.2407
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.23915
CCN3 cellular communication network factor 3 -2.23518
JHY junctional cadherin complex regulator -2.2298
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) -2.22835
MYH1 myosin, heavy chain 1, skeletal muscle, adult -2.21775
SIGLEC15 sialic acid binding Ig-like lectin 15 -2.20135
CAPN5 calpain 5 -2.1975
LOC124907012 endogenous retrovirus group K member 7 Env polyprotein-like -2.1693
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -2.1673
SLCO5A1 solute carrier organic anion transporter family, member 5A1 -2.16465
ZNF548 zinc finger protein 548 -2.15375
NGRN neugrin, neurite outgrowth associated -2.14765
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 -2.14575
LINS1 lines homolog 1 -2.14465
ANKRD6 ankyrin repeat domain 6 -2.13955
MYOZ2 myozenin 2 -2.13608
FUBP3 far upstream element (FUSE) binding protein 3 -2.12795
HRC histidine rich calcium binding protein -2.12315
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 -2.12225
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -2.11972
ARL15 ADP-ribosylation factor-like 15 -2.1153
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough -2.1141
ADAMDEC1 ADAM-like, decysin 1 -2.11185
PTPRR protein tyrosine phosphatase, receptor type, R -2.11077
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -2.10585
FAM131B family with sequence similarity 131, member B -2.1058
SH3GLB2 SH3-domain GRB2-like endophilin B2 -2.1038
ATG5 autophagy related 5 -2.10135
SAMD9 sterile alpha motif domain containing 9 -2.0993
GREB1L growth regulation by estrogen in breast cancer-like -2.0976
KRT20 keratin 20, type I -2.0828
SYNGR2 synaptogyrin 2 -2.076
BAD BCL2-associated agonist of cell death -2.0652
AP4M1 adaptor-related protein complex 4, mu 1 subunit -2.06295
HEBP2 heme binding protein 2 -2.05815
HCCS holocytochrome c synthase -2.05058
CDH12 cadherin 12, type 2 (N-cadherin 2) -2.04985
TRIM36 tripartite motif containing 36 -2.0464
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -2.04575
TMCC1 transmembrane and coiled-coil domain family 1 -2.04505
ZNF253 zinc finger protein 253 -2.041
TMEM255A transmembrane protein 255A -2.0394
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -2.03175
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 -2.0283
YIPF1 Yip1 domain family, member 1 -2.02735
TRAT1 T cell receptor associated transmembrane adaptor 1 -2.0224
SYTL2 synaptotagmin-like 2 -2.0207
XPA xeroderma pigmentosum, complementation group A -2.0172
GAN gigaxonin -2.01695
EYA4 EYA transcriptional coactivator and phosphatase 4 -2.0155
RRH retinal pigment epithelium-derived rhodopsin homolog -2.0124
RBM12 RNA binding motif protein 12 -2.00362