CRCGN017_MCF10A.WT.HP_24H:H14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzoin 33.49 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:H14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.83425
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.4418
WASF3 WAS protein family, member 3 4.2056
ZW10 zw10 kinetochore protein 3.9134
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.8728
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 3.5068
ACAA1 acetyl-CoA acyltransferase 1 3.4115
NPDC1 neural proliferation, differentiation and control, 1 2.6179
CGRRF1 cell growth regulator with ring finger domain 1 2.59485
PKN1 protein kinase N1 2.55545
THAP12 THAP domain containing 12 2.51635
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.47725
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.43525
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.34645
OLFML2B olfactomedin-like 2B 2.33575
GSTZ1 glutathione S-transferase zeta 1 2.33175
TNK1 tyrosine kinase, non-receptor, 1 2.31915
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.2703
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.1297
MBIP MAP3K12 binding inhibitory protein 1 2.0053
HBA1 hemoglobin, alpha 1 2.00283

decreased expression

Symbol Name Standardized Value
NUSAP1 nucleolar and spindle associated protein 1 -6.74808
GDF15 growth differentiation factor 15 -6.1996
HAT1 histone acetyltransferase 1 -5.2561
MAPK13 mitogen-activated protein kinase 13 -5.1602
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.97065
CHIC2 cysteine-rich hydrophobic domain 2 -4.9471
SGK1 serum/glucocorticoid regulated kinase 1 -4.8459
MRPS2 mitochondrial ribosomal protein S2 -4.53605
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.31108
PPP1R26 protein phosphatase 1, regulatory subunit 26 -4.0006
MSMO1 methylsterol monooxygenase 1 -3.3187
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.13085
PAEP progestagen-associated endometrial protein -3.02625
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 -2.9097
YPEL5 yippee-like 5 (Drosophila) -2.64755
RAI14 retinoic acid induced 14 -2.60815
ATXN7 ataxin 7 -2.49323
RPAP1 RNA polymerase II associated protein 1 -2.2905
THAP11 THAP domain containing 11 -2.28985
FAT4 FAT atypical cadherin 4 -2.2801
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -2.25685
RRM2 ribonucleotide reductase M2 -2.24067
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -2.23945
CTSW cathepsin W -2.2381
EXD3 exonuclease 3'-5' domain containing 3 -2.20155
MTERF3 mitochondrial transcription termination factor 3 -2.19925
FMNL3 formin-like 3 -2.18765
KEL Kell blood group, metallo-endopeptidase -2.18465
UBAC1 UBA domain containing 1 -2.1695
IL3 interleukin 3 -2.1668
ALG12 ALG12, alpha-1,6-mannosyltransferase -2.13055
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 -2.1193
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 -2.10845
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -2.09433
PTCD1 pentatricopeptide repeat domain 1 -2.0798
CHAMP1 chromosome alignment maintaining phosphoprotein 1 -2.0742
MREG melanoregulin -2.06965
RDH8 retinol dehydrogenase 8 (all-trans) -2.03905
HYAL4 hyaluronoglucosaminidase 4 -2.037
SPG11 spastic paraplegia 11 (autosomal recessive) -2.01945
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.01008
PPP1R15A protein phosphatase 1, regulatory subunit 15A -2.0039