CRCGN017_MCF10A.WT.HP_24H:H16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caffeine 101.98 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:H16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 5.45765
MAP7 microtubule-associated protein 7 5.37927
KLHL21 kelch-like family member 21 3.93585
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.874
TXNRD1 thioredoxin reductase 1 3.8182
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.7277
LYRM1 LYR motif containing 1 3.5806
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.50163
HMOX1 heme oxygenase 1 3.3239
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 3.241
WIF1 WNT inhibitory factor 1 2.94905
SESN1 sestrin 1 2.9445
STAMBP STAM binding protein 2.80835
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.79355
LRP10 low density lipoprotein receptor-related protein 10 2.7225
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 2.69925
INPP1 inositol polyphosphate-1-phosphatase 2.6166
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.61615
CCL2 chemokine (C-C motif) ligand 2 2.5084
SKIC8 SKI8 subunit of superkiller complex 2.32955
CEMIP2 cell migration inducing hyaluronidase 2 2.3013
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.2687
ASCC3 activating signal cointegrator 1 complex subunit 3 2.2495
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.2046
ECD ecdysoneless homolog (Drosophila) 2.1803
SQOR sulfide quinone oxidoreductase 2.1724
ADGRE5 adhesion G protein-coupled receptor E5 2.15485
MICALL1 MICAL-like 1 2.05955
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 2.0416
HSPA4L heat shock 70kDa protein 4-like 2.036
AMDHD2 amidohydrolase domain containing 2 2.02085
SKIC2 SKI2 subunit of superkiller complex 2.01885
POPDC3 popeye domain containing 3 2.0175

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -5.57705
MAPK13 mitogen-activated protein kinase 13 -4.48032
ETFB electron-transfer-flavoprotein, beta polypeptide -3.98305
PSRC1 proline/serine-rich coiled-coil 1 -3.54095
PCCB propionyl CoA carboxylase, beta polypeptide -3.44785
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.43975
PLK1 polo-like kinase 1 -3.21995
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.98645
NCAPD2 non-SMC condensin I complex, subunit D2 -2.9748
FBXO21 F-box protein 21 -2.72005
NLRP2 NLR family, pyrin domain containing 2 -2.6191
ARID4B AT rich interactive domain 4B (RBP1-like) -2.5453
KIF20A kinesin family member 20A -2.4295
CCNB1 cyclin B1 -2.2869
FPGS folylpolyglutamate synthase -2.26515
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.2534
PIMREG PICALM interacting mitotic regulator -2.24115
CCNB2 cyclin B2 -2.23615
TRDMT1 tRNA aspartic acid methyltransferase 1 -2.1027
CD320 CD320 molecule -2.0453
ZNF318 zinc finger protein 318 -2.04443
UBE2C ubiquitin-conjugating enzyme E2C -2.017
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.00715