CRCGN017_MCF10A.WT.HP_24H:H17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caffeine 33.99 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:H17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.30785
ADAM10 ADAM metallopeptidase domain 10 4.67238
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.5904
UGDH UDP-glucose 6-dehydrogenase 2.3849
SESN1 sestrin 1 2.30605
METRN meteorin, glial cell differentiation regulator 2.252
SNX11 sorting nexin 11 2.15995
TMX2 thioredoxin-related transmembrane protein 2 2.1279
NCOA4 nuclear receptor coactivator 4 2.0381
ATP5MC1 ATP synthase membrane subunit c locus 1 2.0263

decreased expression

Symbol Name Standardized Value
EXOSC4 exosome component 4 -6.9489
KRT14 keratin 14, type I -6.4033
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.72895
TNIP1 TNFAIP3 interacting protein 1 -4.6351
ADI1 acireductone dioxygenase 1 -4.49795
CD320 CD320 molecule -4.49445
RNF167 ring finger protein 167 -3.85315
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.51795
CORO1A coronin, actin binding protein, 1A -3.3414
PFN1 profilin 1 -3.3168
COPS7A COP9 signalosome subunit 7A -3.1797
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.73788
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.4857
MT2A metallothionein 2A -2.47545
XPO7 exportin 7 -2.23997
SOCS1 suppressor of cytokine signaling 1 -2.16765
WASHC4 WASH complex subunit 4 -2.07492
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.06315
AOX1 aldehyde oxidase 1 -2.05732
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 -2.04085
LIMD2 LIM domain containing 2 -2.0366