CRCGN017_MCF10A.WT.HP_24H:H19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,3-propane sultone 100.3 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:H19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NANOS3 nanos homolog 3 (Drosophila) 5.32925
CNRIP1 cannabinoid receptor interacting protein 1 5.09705
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.3604
VGLL4 vestigial-like family member 4 3.77485
WDR7 WD repeat domain 7 3.6224
OLFML2B olfactomedin-like 2B 3.61145
COMP cartilage oligomeric matrix protein 3.38325
IGHMBP2 immunoglobulin mu binding protein 2 3.1951
CCL2 chemokine (C-C motif) ligand 2 2.8194
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.75087
KANSL1 KAT8 regulatory NSL complex subunit 1 2.5385
PLS1 plastin 1 2.41015
CCNE2 cyclin E2 2.2737
FAM110D family with sequence similarity 110, member D 2.27075
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.2306
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 2.23015
SOCS3 suppressor of cytokine signaling 3 2.19645
PDHB pyruvate dehydrogenase (lipoamide) beta 2.15998
HIGD1A HIG1 hypoxia inducible domain family, member 1A 2.13675
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 2.1186
GMPS guanine monphosphate synthase 2.0866
RNF144A ring finger protein 144A 2.06685
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 2.0598
STX17 syntaxin 17 2.0582
DENND1A DENN/MADD domain containing 1A 2.05175
HYAL2 hyaluronoglucosaminidase 2 2.04875
TPPP tubulin polymerization promoting protein 2.0006

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.3559
CANT1 calcium activated nucleotidase 1 -5.03675
GOLT1B golgi transport 1B -4.7844
YME1L1 YME1-like 1 ATPase -4.71235
CD81 CD81 molecule -4.3423
PMM2 phosphomannomutase 2 -4.3112
RXYLT1 ribitol xylosyltransferase 1 -3.69633
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.37145
WASHC4 WASH complex subunit 4 -3.17735
MT2A metallothionein 2A -3.1011
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.53868
XPOT exportin, tRNA -2.51535
ABI1 abl-interactor 1 -2.44007
SPIB Spi-B transcription factor (Spi-1/PU.1 related) -2.3189
RECQL RecQ helicase-like -2.23349
LEMD3 LEM domain containing 3 -2.22295
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -2.2229
ATP10D ATPase, class V, type 10D -2.2212
BCAS4 breast carcinoma amplified sequence 4 -2.2127
MSN moesin -2.19045
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.12895
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 -2.11305
SGK1 serum/glucocorticoid regulated kinase 1 -2.0356