CRCGN017_MCF10A.WT.HP_24H:H20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,3-propane sultone 33.43 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

28 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:H20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AXIN1 axin 1 5.09025
ACAA1 acetyl-CoA acyltransferase 1 3.19913
TCTN1 tectonic family member 1 3.054
OLFML2B olfactomedin-like 2B 2.865
NUP205 nucleoporin 205kDa 2.6958
FBXO7 F-box protein 7 2.67955
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 2.51785
STAMBP STAM binding protein 2.4411
PLS1 plastin 1 2.33825
CYREN cell cycle regulator of NHEJ 2.30305
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 2.2977
VTA1 vesicle (multivesicular body) trafficking 1 2.25775
ASCC2 activating signal cointegrator 1 complex subunit 2 2.21955
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.1142
CHEK2 checkpoint kinase 2 2.1025
MINDY1 MINDY lysine 48 deubiquitinase 1 2.09045
CCL2 chemokine (C-C motif) ligand 2 2.0777
GSTK1 glutathione S-transferase kappa 1 2.02105

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -5.26945
KRT14 keratin 14, type I -5.0
SGK1 serum/glucocorticoid regulated kinase 1 -4.2881
CANT1 calcium activated nucleotidase 1 -3.76483
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.58925
FPGS folylpolyglutamate synthase -3.4046
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -3.01358
CCNL2 cyclin L2 -2.2535
PLXDC1 plexin domain containing 1 -2.13812
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.02275