CRCGN017_MCF10A.WT.HP_24H:H21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,3-propane sultone 11.14 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

36 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:H21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 4.80225
CHEK1 checkpoint kinase 1 4.44317
PPARG peroxisome proliferator-activated receptor gamma 4.30205
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.8606
EPN2 epsin 2 3.34998
TIAM1 T-cell lymphoma invasion and metastasis 1 3.3126
VAV3 vav 3 guanine nucleotide exchange factor 3.00955
IGHMBP2 immunoglobulin mu binding protein 2 2.9238
TJP2 tight junction protein 2 2.59635
GARRE1 granule associated Rac and RHOG effector 1 2.5026
PLS1 plastin 1 2.37035
RBM7 RNA binding motif protein 7 2.3597
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.32288
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 2.11795
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.06017
CCL22 chemokine (C-C motif) ligand 22 2.04245

decreased expression

Symbol Name Standardized Value
VDAC1 voltage-dependent anion channel 1 -4.74185
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.5413
RBM34 RNA binding motif protein 34 -3.20042
THAP11 THAP domain containing 11 -2.84375
ACAA1 acetyl-CoA acyltransferase 1 -2.73015
SMC1A structural maintenance of chromosomes 1A -2.5987
BPHL biphenyl hydrolase-like (serine hydrolase) -2.3252
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.23655
CUBN cubilin (intrinsic factor-cobalamin receptor) -2.2297
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -2.1624
SIRT7 sirtuin 7 -2.14295
RTCA RNA 3'-terminal phosphate cyclase -2.1363
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound -2.1193
GDF15 growth differentiation factor 15 -2.06905
TUBA4A tubulin, alpha 4a -2.04775
AMIGO2 adhesion molecule with Ig-like domain 2 -2.03485
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.01625
VIPR1 vasoactive intestinal peptide receptor 1 -2.01345
RPF1 ribosome production factor 1 homolog (S. cerevisiae) -2.01025
KIZ kizuna centrosomal protein -2.0005