CRCGN017_MCF10A.WT.HP_24H:I01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-aminoazotoluene 99.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

247 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:I01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 5.21061
NUCB2 nucleobindin 2 5.04839
MSRA methionine sulfoxide reductase A 4.97459
GLRX glutaredoxin (thioltransferase) 4.94512
SQOR sulfide quinone oxidoreductase 4.84526
UBE2L6 ubiquitin-conjugating enzyme E2L 6 4.40367
ISG15 ISG15 ubiquitin-like modifier 4.38678
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.2281
TNIP1 TNFAIP3 interacting protein 1 4.15682
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.03647
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.96631
STX4 syntaxin 4 3.75471
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 3.67078
AGR2 anterior gradient 2 3.64455
CEMIP2 cell migration inducing hyaluronidase 2 3.63955
STAT1 signal transducer and activator of transcription 1, 91kDa 3.58856
CNPY3 canopy FGF signaling regulator 3 3.52671
IL1B interleukin 1, beta 3.52111
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.51564
IFI35 interferon-induced protein 35 3.49154
PARP12 poly (ADP-ribose) polymerase family, member 12 3.393
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.33493
WFS1 Wolfram syndrome 1 (wolframin) 3.3079
RPN1 ribophorin I 3.27168
IER3 immediate early response 3 3.25966
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.21309
RIGI RNA sensor RIG-I 3.19622
RAP1GAP RAP1 GTPase activating protein 3.15026
BLCAP bladder cancer associated protein 3.11297
E2F2 E2F transcription factor 2 3.07396
MX1 MX dynamin-like GTPase 1 3.03124
CTSL cathepsin L 3.0155
IRF9 interferon regulatory factor 9 2.88961
IFI6 interferon, alpha-inducible protein 6 2.87469
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.8244
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.78769
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.77565
LRP10 low density lipoprotein receptor-related protein 10 2.77198
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.732
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.71623
WIF1 WNT inhibitory factor 1 2.7005
ZC3H12A zinc finger CCCH-type containing 12A 2.68511
FGFR4 fibroblast growth factor receptor 4 2.66484
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 2.65675
UGDH UDP-glucose 6-dehydrogenase 2.64526
IFITM1 interferon induced transmembrane protein 1 2.62408
UBQLN2 ubiquilin 2 2.58727
NIT1 nitrilase 1 2.55852
LARP6 La ribonucleoprotein domain family, member 6 2.51381
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.50302
IRF7 interferon regulatory factor 7 2.48567
IL4R interleukin 4 receptor 2.48555
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.45857
C2CD2 C2 calcium-dependent domain containing 2 2.41783
KLC3 kinesin light chain 3 2.38714
TM9SF3 transmembrane 9 superfamily member 3 2.37248
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.36892
IFI44L interferon-induced protein 44-like 2.36727
APOL1 apolipoprotein L, 1 2.36384
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.35878
LY6E lymphocyte antigen 6 complex, locus E 2.32948
PMP22 peripheral myelin protein 22 2.31662
EPN2 epsin 2 2.31525
CKAP4 cytoskeleton-associated protein 4 2.28546
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.23258
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.22847
HIP1R huntingtin interacting protein 1 related 2.22015
IFI27 interferon, alpha-inducible protein 27 2.2096
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 2.18822
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.18609
GARS1 glycyl-tRNA synthetase 1 2.17594
HYOU1 hypoxia up-regulated 1 2.16134
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 2.14855
OXSR1 oxidative stress responsive 1 2.13834
TRIB1 tribbles pseudokinase 1 2.13783
TENT4A terminal nucleotidyltransferase 4A 2.12967
CHIC2 cysteine-rich hydrophobic domain 2 2.12769
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.10559
DUSP4 dual specificity phosphatase 4 2.09147
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.08747
STXBP1 syntaxin binding protein 1 2.06957
SPINT1 serine peptidase inhibitor, Kunitz type 1 2.06882
DCTN1 dynactin 1 2.04999
CANT1 calcium activated nucleotidase 1 2.04465
ACAA1 acetyl-CoA acyltransferase 1 2.04061
IL15RA interleukin 15 receptor, alpha 2.0274
KCTD5 potassium channel tetramerization domain containing 5 2.01096
PRAF2 PRA1 domain family, member 2 2.0015

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -6.44536
HOXA5 homeobox A5 -6.14357
CCNB2 cyclin B2 -5.28674
CDC20 cell division cycle 20 -5.26617
ZDHHC6 zinc finger, DHHC-type containing 6 -5.13564
UBE2C ubiquitin-conjugating enzyme E2C -4.69297
KIF20A kinesin family member 20A -4.67928
STMN1 stathmin 1 -4.34551
HMG20B high mobility group 20B -4.12456
CCNA2 cyclin A2 -4.12448
PLK1 polo-like kinase 1 -4.064
SOAT2 sterol O-acyltransferase 2 -3.9869
PSRC1 proline/serine-rich coiled-coil 1 -3.95654
DCK deoxycytidine kinase -3.92054
CDK1 cyclin-dependent kinase 1 -3.90985
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -3.82264
TSC22D3 TSC22 domain family, member 3 -3.7878
NLRP4 NLR family, pyrin domain containing 4 -3.78104
PARP2 poly (ADP-ribose) polymerase 2 -3.7603
NT5DC2 5'-nucleotidase domain containing 2 -3.73343
ALDOC aldolase C, fructose-bisphosphate -3.68778
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -3.594
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.58746
HOXA4 homeobox A4 -3.57654
TOP2A topoisomerase (DNA) II alpha 170kDa -3.55931
YME1L1 YME1-like 1 ATPase -3.54705
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.51036
ETFB electron-transfer-flavoprotein, beta polypeptide -3.41802
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.37442
COG2 component of oligomeric golgi complex 2 -3.36039
BIRC5 baculoviral IAP repeat containing 5 -3.34772
GTF2A2 general transcription factor IIA, 2, 12kDa -3.27543
LDHD lactate dehydrogenase D -3.16779
KHDC4 KH domain containing 4, pre-mRNA splicing factor -3.05152
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.99163
SESN1 sestrin 1 -2.96954
NRIP1 nuclear receptor interacting protein 1 -2.9054
NUSAP1 nucleolar and spindle associated protein 1 -2.90073
ANGPTL7 angiopoietin-like 7 -2.90058
PCNA proliferating cell nuclear antigen -2.87103
CDK7 cyclin-dependent kinase 7 -2.86791
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.86527
ZNF134 zinc finger protein 134 -2.86363
GABPA GA binding protein transcription factor, alpha subunit 60kDa -2.85799
HADH hydroxyacyl-CoA dehydrogenase -2.83984
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.82637
AURKA aurora kinase A -2.81684
IKZF5 IKAROS family zinc finger 5 (Pegasus) -2.75916
KIF14 kinesin family member 14 -2.74769
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.73331
ASF1B anti-silencing function 1B histone chaperone -2.71544
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.68179
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.66615
OXA1L oxidase (cytochrome c) assembly 1-like -2.66012
GEMIN2 gem (nuclear organelle) associated protein 2 -2.62393
SMC4 structural maintenance of chromosomes 4 -2.59528
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.58584
TMEM267 transmembrane protein 267 -2.58159
CENPA centromere protein A -2.562
TBP TATA box binding protein -2.54459
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.53578
POT1 protection of telomeres 1 -2.47147
SH3D19 SH3 domain containing 19 -2.46267
CD58 CD58 molecule -2.46218
MVD mevalonate (diphospho) decarboxylase -2.45928
RACGAP1 Rac GTPase activating protein 1 -2.45919
NEK2 NIMA-related kinase 2 -2.45745
CDKN3 cyclin-dependent kinase inhibitor 3 -2.45513
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -2.43289
SLC25A40 solute carrier family 25, member 40 -2.43102
CHODL chondrolectin -2.41236
ATG3 autophagy related 3 -2.41161
SORBS3 sorbin and SH3 domain containing 3 -2.40316
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.38669
ECD ecdysoneless homolog (Drosophila) -2.38137
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.37433
CCNB1 cyclin B1 -2.35802
SMNDC1 survival motor neuron domain containing 1 -2.34192
FASN fatty acid synthase -2.3295
SPAG5 sperm associated antigen 5 -2.31634
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.31203
CDC40 cell division cycle 40 -2.30401
PRPF18 pre-mRNA processing factor 18 -2.30107
HEATR1 HEAT repeat containing 1 -2.28886
ELP4 elongator acetyltransferase complex subunit 4 -2.28809
TPX2 TPX2, microtubule-associated -2.27921
PTTG1 pituitary tumor-transforming 1 -2.27324
CETN3 centrin, EF-hand protein, 3 -2.27014
NLRP2B NLR family pyrin domain containing 2B -2.26909
CAPRIN1 cell cycle associated protein 1 -2.2619
PSIP1 PC4 and SFRS1 interacting protein 1 -2.26005
KIF4A kinesin family member 4A -2.25593
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.25104
ARHGAP19 Rho GTPase activating protein 19 -2.24614
MOCS2 molybdenum cofactor synthesis 2 -2.24512
TCERG1 transcription elongation regulator 1 -2.23625
NCAPH non-SMC condensin I complex, subunit H -2.23484
SPDL1 spindle apparatus coiled-coil protein 1 -2.22844
PRC1 protein regulator of cytokinesis 1 -2.22563
ARID4B AT rich interactive domain 4B (RBP1-like) -2.22506
AK6 adenylate kinase 6 -2.22486
MRPL39 mitochondrial ribosomal protein L39 -2.22357
HMGB2 high mobility group box 2 -2.22082
TUBGCP4 tubulin, gamma complex associated protein 4 -2.21907
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.21244
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.20834
CDCA8 cell division cycle associated 8 -2.20432
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.18539
PFDN1 prefoldin subunit 1 -2.17607
CDCA3 cell division cycle associated 3 -2.17087
ASF1A anti-silencing function 1A histone chaperone -2.16855
SEC23A Sec23 homolog A (S. cerevisiae) -2.16714
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.15689
TMOD3 tropomodulin 3 (ubiquitous) -2.14752
CD320 CD320 molecule -2.13851
HOXA1 homeobox A1 -2.13466
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.12616
SKAP2 src kinase associated phosphoprotein 2 -2.12542
EML4 echinoderm microtubule associated protein like 4 -2.1221
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.12174
ELOVL2 ELOVL fatty acid elongase 2 -2.11835
RFC3 replication factor C (activator 1) 3, 38kDa -2.11819
ENOPH1 enolase-phosphatase 1 -2.11323
DCLRE1A DNA cross-link repair 1A -2.11265
COQ3 coenzyme Q3 methyltransferase -2.09144
WDR83OS WD repeat domain 83 opposite strand -2.09018
MRPS16 mitochondrial ribosomal protein S16 -2.08991
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) -2.08308
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.08065
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.0779
CENPN centromere protein N -2.07615
MECR mitochondrial trans-2-enoyl-CoA reductase -2.07363
LBR lamin B receptor -2.06899
PDLIM2 PDZ and LIM domain 2 (mystique) -2.06533
CHKA choline kinase alpha -2.0651
RFC2 replication factor C (activator 1) 2, 40kDa -2.06083
SHCBP1 SHC SH2-domain binding protein 1 -2.0584
MRPL11 mitochondrial ribosomal protein L11 -2.05623
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.04861
RPP30 ribonuclease P/MRP 30kDa subunit -2.04432
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.0438
EAPP E2F-associated phosphoprotein -2.04253
RPA3 replication protein A3, 14kDa -2.04246
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) -2.0402
MIS12 MIS12 kinetochore complex component -2.03558
FBXO5 F-box protein 5 -2.03254
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.03189
RPL39L ribosomal protein L39-like -2.02765
DLAT dihydrolipoamide S-acetyltransferase -2.02424
TROAP trophinin associated protein -2.02262
PLP1 proteolipid protein 1 -2.02053
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -2.02018
AGPS alkylglycerone phosphate synthase -2.01516
ACYP1 acylphosphatase 1, erythrocyte (common) type -2.01288
SGCE sarcoglycan, epsilon -2.0122
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -2.0121
COX15 cytochrome c oxidase assembly homolog 15 (yeast) -2.00767
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -2.00137
NSUN3 NOP2/Sun domain family, member 3 -2.00099