CRCGN017_MCF10A.WT.HP_24H:I03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-aminoazotoluene 11.09 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

28 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:I03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.92699
IGHMBP2 immunoglobulin mu binding protein 2 4.7455
CCL2 chemokine (C-C motif) ligand 2 3.51149
E2F2 E2F transcription factor 2 3.14309
TIAM1 T-cell lymphoma invasion and metastasis 1 2.85414
COMP cartilage oligomeric matrix protein 2.75271
ZW10 zw10 kinetochore protein 2.50083
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.49836
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.39001
HMX1 H6 family homeobox 1 2.30681
PDCD1 programmed cell death 1 2.22118
CD40LG CD40 ligand 2.16739
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.1453
MCUB mitochondrial calcium uniporter dominant negative subunit beta 2.09932
RAX retina and anterior neural fold homeobox 2.07995
IKZF4 IKAROS family zinc finger 4 (Eos) 2.01346
PRODH proline dehydrogenase (oxidase) 1 2.00322
FAT2 FAT atypical cadherin 2 2.00197

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -6.80615
CCDC86 coiled-coil domain containing 86 -5.01858
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.91099
ARID4B AT rich interactive domain 4B (RBP1-like) -2.65507
GOLT1B golgi transport 1B -2.27039
HLA-DMA major histocompatibility complex, class II, DM alpha -2.22185
GRN granulin -2.14487
NGRN neugrin, neurite outgrowth associated -2.11933
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.06672
STAT1 signal transducer and activator of transcription 1, 91kDa -2.03848