| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | isoniazid 33.43 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome) |
| Similar Terms | |
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88 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:I05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPAG4 | sperm associated antigen 4 | 3.84621 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 3.82658 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 3.7507 |
| COMP | cartilage oligomeric matrix protein | 3.65991 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 3.63773 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.63009 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 3.55385 |
| PRAF2 | PRA1 domain family, member 2 | 3.44952 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 3.44173 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 3.32084 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | 3.17709 |
| MAMLD1 | mastermind-like domain containing 1 | 3.11787 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.11518 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 3.11339 |
| EAPP | E2F-associated phosphoprotein | 3.10947 |
| EPM2AIP1 | EPM2A (laforin) interacting protein 1 | 3.10094 |
| KIF5C | kinesin family member 5C | 2.98795 |
| IDE | insulin-degrading enzyme | 2.81635 |
| F2R | coagulation factor II (thrombin) receptor | 2.71132 |
| OLFML2B | olfactomedin-like 2B | 2.61342 |
| MED4 | mediator complex subunit 4 | 2.44984 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 2.41376 |
| MYLK | myosin light chain kinase | 2.40185 |
| CD302 | CD302 molecule | 2.39945 |
| ACAA1 | acetyl-CoA acyltransferase 1 | 2.38101 |
| PRKCH | protein kinase C, eta | 2.3429 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 2.33292 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.31983 |
| NOSIP | nitric oxide synthase interacting protein | 2.30683 |
| ILKAP | integrin-linked kinase-associated serine/threonine phosphatase | 2.23234 |
| ANO10 | anoctamin 10 | 2.14902 |
| AGR2 | anterior gradient 2 | 2.14121 |
| HBA1 | hemoglobin, alpha 1 | 2.13924 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 2.1317 |
| PLP1 | proteolipid protein 1 | 2.09407 |
| MAP7 | microtubule-associated protein 7 | 2.0912 |
| WDR7 | WD repeat domain 7 | 2.08561 |
| CERK | ceramide kinase | 2.07818 |
| CST7 | cystatin F (leukocystatin) | 2.04881 |
| ZNF430 | zinc finger protein 430 | 2.03895 |
| COQ8A | coenzyme Q8A | 2.03042 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 2.01519 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GDF15 | growth differentiation factor 15 | -5.00805 |
| KIF20A | kinesin family member 20A | -4.99591 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -4.365 |
| KRT14 | keratin 14, type I | -4.19425 |
| PMM2 | phosphomannomutase 2 | -3.92769 |
| DSG2 | desmoglein 2 | -3.86585 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -3.83641 |
| ACOT9 | acyl-CoA thioesterase 9 | -3.83471 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -3.74026 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.59926 |
| DNM1L | dynamin 1-like | -3.56366 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -3.55924 |
| CCNB1 | cyclin B1 | -3.54874 |
| RPIA | ribose 5-phosphate isomerase A | -3.46568 |
| MSMO1 | methylsterol monooxygenase 1 | -3.36092 |
| VAT1 | vesicle amine transport 1 | -3.19205 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -3.11441 |
| CAB39 | calcium binding protein 39 | -3.10387 |
| HSPA8 | heat shock 70kDa protein 8 | -3.06271 |
| CD81 | CD81 molecule | -3.04169 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -2.99484 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -2.89175 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -2.85439 |
| NMRK2 | nicotinamide riboside kinase 2 | -2.65161 |
| TXNDC9 | thioredoxin domain containing 9 | -2.62516 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | -2.57399 |
| MSN | moesin | -2.54829 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -2.5385 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.47617 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -2.46865 |
| YARS2 | tyrosyl-tRNA synthetase 2, mitochondrial | -2.46508 |
| PRPF4 | pre-mRNA processing factor 4 | -2.45666 |
| VTI1B | vesicle transport through interaction with t-SNAREs 1B | -2.33068 |
| TBCE | tubulin folding cofactor E | -2.3068 |
| CDC45 | cell division cycle 45 | -2.20987 |
| APOO | apolipoprotein O | -2.16283 |
| HEXB | hexosaminidase B (beta polypeptide) | -2.15272 |
| PFN1 | profilin 1 | -2.15014 |
| PRSS23 | protease, serine, 23 | -2.11861 |
| FAM13B | family with sequence similarity 13, member B | -2.10486 |
| PLD3 | phospholipase D family, member 3 | -2.07555 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -2.07374 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -2.05464 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -2.03055 |
| PLK1 | polo-like kinase 1 | -2.02467 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -2.0227 |
