CRCGN017_MCF10A.WT.HP_24H:I08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description roxarsone 33.1 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:I08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STK10 serine/threonine kinase 10 4.7586
CCDC92 coiled-coil domain containing 92 4.02645
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.48872
CCNF cyclin F 2.99952
ACAA1 acetyl-CoA acyltransferase 1 2.98625
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.91112
CNRIP1 cannabinoid receptor interacting protein 1 2.78625
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.7683
COQ8A coenzyme Q8A 2.44895
NOSIP nitric oxide synthase interacting protein 2.38165
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.3448
PRR7 proline rich 7 (synaptic) 2.26995
ARID5B AT rich interactive domain 5B (MRF1-like) 2.237
FGFR2 fibroblast growth factor receptor 2 2.15159
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.13645
CLIP2 CAP-GLY domain containing linker protein 2 2.07395
GCN1 GCN1 activator of EIF2AK4 2.06505
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 2.0641

decreased expression

Symbol Name Standardized Value
UFM1 ubiquitin-fold modifier 1 -5.52435
TXNDC9 thioredoxin domain containing 9 -5.47267
CCNB1 cyclin B1 -5.3111
SLC35F2 solute carrier family 35, member F2 -4.8349
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -4.4103
SNX7 sorting nexin 7 -3.85595
EXOSC4 exosome component 4 -3.20555
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.91045
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.55703
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.51087
IFRD2 interferon-related developmental regulator 2 -2.47655
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -2.34835
STAC SH3 and cysteine rich domain -2.3384
GOLPH3L golgi phosphoprotein 3-like -2.13885
MTMR6 myotubularin related protein 6 -2.1383
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.1061
CDX1 caudal type homeobox 1 -2.07065
ZNF552 zinc finger protein 552 -2.05905
AK6 adenylate kinase 6 -2.05735
MTERF3 mitochondrial transcription termination factor 3 -2.0046