CRCGN017_MCF10A.WT.HP_24H:I09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description roxarsone 11.03 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

118 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:I09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.0
IDE insulin-degrading enzyme 4.6732
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 4.05835
RTN2 reticulon 2 3.99848
PXMP4 peroxisomal membrane protein 4, 24kDa 3.31305
ACAA1 acetyl-CoA acyltransferase 1 3.19973
RB1 retinoblastoma 1 3.1714
ACTL6A actin-like 6A 2.9225
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 2.7167
WIF1 WNT inhibitory factor 1 2.6816
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 2.6479
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.49035
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2.4485
STRN4 striatin, calmodulin binding protein 4 2.42985
CCL2 chemokine (C-C motif) ligand 2 2.2606
DCTN1 dynactin 1 2.2567
PHF10 PHD finger protein 10 2.2488
SATB1 SATB homeobox 1 2.24625
RNF123 ring finger protein 123 2.1832
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 2.16585
TBC1D10B TBC1 domain family, member 10B 2.15705
UBA1 ubiquitin-like modifier activating enzyme 1 2.1446
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 2.12835
MICU1 mitochondrial calcium uptake 1 2.1272
SAE1 SUMO1 activating enzyme subunit 1 2.08965
ZFYVE16 zinc finger, FYVE domain containing 16 2.07405
POLR2M polymerase (RNA) II (DNA directed) polypeptide M 2.0516
DGCR6L DiGeorge syndrome critical region gene 6-like 2.0465
AUP1 ancient ubiquitous protein 1 2.0393
CTBP2 C-terminal binding protein 2 2.032
RBL2 retinoblastoma-like 2 2.02287
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 2.0199
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 2.0049
NYNRIN NYN domain and retroviral integrase containing 2.00055

decreased expression

Symbol Name Standardized Value
LAP3 leucine aminopeptidase 3 -10.0
KRT14 keratin 14, type I -6.4488
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -6.1213
HSPA8 heat shock 70kDa protein 8 -5.58662
LDHD lactate dehydrogenase D -4.8664
TUBB6 tubulin, beta 6 class V -4.74535
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.1239
TLCD3A TLC domain containing 3A -3.7945
RTRAF RNA transcription, translation and transport factor -3.39815
TKT transketolase -3.27677
PUS3 pseudouridylate synthase 3 -3.08245
RBM34 RNA binding motif protein 34 -3.04377
METTL18 methyltransferase like 18 -2.9701
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.91955
RPL36AL ribosomal protein L36a-like -2.89555
MED28 mediator complex subunit 28 -2.8868
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent -2.84055
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -2.76775
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) -2.7328
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 -2.7313
RPL26L1 ribosomal protein L26-like 1 -2.6919
SAMHD1 SAM domain and HD domain 1 -2.6881
PRELID3A PRELI domain containing 3A -2.64765
AP5M1 adaptor-related protein complex 5, mu 1 subunit -2.62915
BCAP29 B-cell receptor-associated protein 29 -2.57835
WASHC4 WASH complex subunit 4 -2.50752
EIF3H eukaryotic translation initiation factor 3, subunit H -2.5067
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -2.5047
CORO1C coronin, actin binding protein, 1C -2.4879
NAMPT nicotinamide phosphoribosyltransferase -2.47385
ARID4A AT rich interactive domain 4A (RBP1-like) -2.47285
HLA-DMB major histocompatibility complex, class II, DM beta -2.4701
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -2.4536
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.434
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.41755
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.4092
LTA4H leukotriene A4 hydrolase -2.39305
LY6E lymphocyte antigen 6 complex, locus E -2.37455
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -2.373
ZNHIT3 zinc finger, HIT-type containing 3 -2.36555
IFI44L interferon-induced protein 44-like -2.3553
EBF2 early B-cell factor 2 -2.34555
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.34247
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma -2.34155
RNF4 ring finger protein 4 -2.30325
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.28525
RPS5 ribosomal protein S5 -2.27925
CD81 CD81 molecule -2.27675
LOC127933115 uncharacterized LOC127933115 -2.2345
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -2.23075
DSE dermatan sulfate epimerase -2.21335
MYH10 myosin, heavy chain 10, non-muscle -2.18355
ANKRD11 ankyrin repeat domain 11 -2.1515
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -2.14453
PPA1 pyrophosphatase (inorganic) 1 -2.1405
CCNG1 cyclin G1 -2.13565
NTM neurotrimin -2.12945
RARS1 arginyl-tRNA synthetase 1 -2.1217
STAT5A signal transducer and activator of transcription 5A -2.1071
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) -2.104
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -2.08905
AKAP12 A kinase (PRKA) anchor protein 12 -2.0819
PEX12 peroxisomal biogenesis factor 12 -2.07795
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) -2.0725
QDPR quinoid dihydropteridine reductase -2.0707
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 -2.06975
CAMLG calcium modulating ligand -2.05985
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.05735
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -2.0515
PMP2 peripheral myelin protein 2 -2.04425
MRPS33 mitochondrial ribosomal protein S33 -2.0435
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.0399
MYL5 myosin, light chain 5, regulatory -2.0343
NCAM2 neural cell adhesion molecule 2 -2.02505
RSAD2 radical S-adenosyl methionine domain containing 2 -2.0246
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.023
ZDHHC7 zinc finger, DHHC-type containing 7 -2.0201
C1R complement component 1, r subcomponent -2.01525
STX18 syntaxin 18 -2.0114
LARP7 La ribonucleoprotein domain family, member 7 -2.01105
PINLYP phospholipase A2 inhibitor and LY6/PLAUR domain containing -2.00715
EIF3E eukaryotic translation initiation factor 3, subunit E -2.0061
CYBA cytochrome b-245, alpha polypeptide -2.0048
RINT1 RAD50 interactor 1 -2.00445