CRCGN017_MCF10A.WT.HP_24H:I11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description promethazine 33.6 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

26 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:I11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.32355
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.62375
AGR2 anterior gradient 2 3.26
FZD7 frizzled class receptor 7 2.4794
CENPE centromere protein E, 312kDa 2.47195
TPD52L2 tumor protein D52-like 2 2.39595
EVL Enah/Vasp-like 2.3059

decreased expression

Symbol Name Standardized Value
DERA deoxyribose-phosphate aldolase (putative) -5.36825
PGAM4 phosphoglycerate mutase family member 4 -5.16185
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.34245
ACAA1 acetyl-CoA acyltransferase 1 -2.84945
WFDC2 WAP four-disulfide core domain 2 -2.39255
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 -2.3436
PRR15L proline rich 15-like -2.2346
RUNDC3B RUN domain containing 3B -2.18575
PFN1 profilin 1 -2.15805
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa -2.10807
IL12A interleukin 12A -2.0872
GRIA2 glutamate receptor, ionotropic, AMPA 2 -2.0743
IL2 interleukin 2 -2.05905
SRFBP1 serum response factor binding protein 1 -2.05025
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -2.034
MARCO macrophage receptor with collagenous structure -2.02315
LIPC lipase, hepatic -2.0205
GPR87 G protein-coupled receptor 87 -2.01225
LOC128966570 alpha-amylase 1B -2.0055