CRCGN017_MCF10A.WT.HP_24H:I16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description xylene mixture (60% m-xylene, 9% o-xylene, 14% p-xylene, 17% ethylbenzene) 96.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:I16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.031
MYLK myosin light chain kinase 4.9223
PRAF2 PRA1 domain family, member 2 4.7902
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 4.66335
IGHMBP2 immunoglobulin mu binding protein 2 4.08632
KIF5C kinesin family member 5C 3.91495
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 3.56693
MSRA methionine sulfoxide reductase A 2.94145
RXYLT1 ribitol xylosyltransferase 1 2.89135
IRS2 insulin receptor substrate 2 2.56207
COQ8A coenzyme Q8A 2.5353
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.5337
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 2.4941
CCNF cyclin F 2.46073
DES desmin 2.33197
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.27422
NOSIP nitric oxide synthase interacting protein 2.2615
GOLM1 golgi membrane protein 1 2.20025
NDFIP1 Nedd4 family interacting protein 1 2.183
FOXO3 forkhead box O3 2.12591
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 2.09345
DBN1 drebrin 1 2.09255
SCML2 sex comb on midleg-like 2 (Drosophila) 2.08545
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.08495
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like 2.0532
FLNA filamin A, alpha 2.04368
TROAP trophinin associated protein 2.03665

decreased expression

Symbol Name Standardized Value
DSG2 desmoglein 2 -5.17145
OXA1L oxidase (cytochrome c) assembly 1-like -4.8865
PCNA proliferating cell nuclear antigen -4.75895
SGK1 serum/glucocorticoid regulated kinase 1 -4.44425
RNF167 ring finger protein 167 -4.2594
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.24953
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -3.9115
COPS7A COP9 signalosome subunit 7A -3.661
HOXA5 homeobox A5 -3.5933
ARID4B AT rich interactive domain 4B (RBP1-like) -3.5166
TRIB3 tribbles pseudokinase 3 -3.2175
MAVS mitochondrial antiviral signaling protein -3.11775
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.07942
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -3.0187
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.8335
ACAA1 acetyl-CoA acyltransferase 1 -2.7773
PANK2 pantothenate kinase 2 -2.76905
DDRGK1 DDRGK domain containing 1 -2.7589
MTERF3 mitochondrial transcription termination factor 3 -2.72705
LINC02762 long intergenic non-protein coding RNA 2762 -2.6433
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 -2.6183
TMEM230 transmembrane protein 230 -2.5699
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.5161
FOSB FBJ murine osteosarcoma viral oncogene homolog B -2.4202
NSFL1C NSFL1 (p97) cofactor (p47) -2.41528
EMC2 ER membrane protein complex subunit 2 -2.409
RGS2 regulator of G-protein signaling 2 -2.3571
CDK5 cyclin-dependent kinase 5 -2.3439
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.32805
ZNF133 zinc finger protein 133 -2.29315
INSIG1 insulin induced gene 1 -2.2762
DUSP14 dual specificity phosphatase 14 -2.27545
DZANK1 double zinc ribbon and ankyrin repeat domains 1 -2.26555
MFAP1 microfibrillar-associated protein 1 -2.2192
GPR137B G protein-coupled receptor 137B -2.1603
CENPB centromere protein B, 80kDa -2.1492
ARHGAP8 Rho GTPase activating protein 8 -2.13755
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -2.12295
SFTPD surfactant protein D -2.11725
SNX5 sorting nexin 5 -2.10295
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.06782
KIF16B kinesin family member 16B -2.0638
LOC102724428 serine/threonine-protein kinase SIK1 -2.05655
GBA1 glucosylceramidase beta 1 -2.04085
FKBP1C FK506 binding protein 1C -2.02677
CSNK2A2 casein kinase 2, alpha prime polypeptide -2.01613