| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | xylene mixture (60% m-xylene, 9% o-xylene, 14% p-xylene, 17% ethylbenzene) 32.27 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome) |
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160 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:I17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 5.27499 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 5.2666 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 5.10462 |
| AMDHD2 | amidohydrolase domain containing 2 | 4.97105 |
| SPAG4 | sperm associated antigen 4 | 4.8545 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 4.66275 |
| INTS3 | integrator complex subunit 3 | 4.1177 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 3.802 |
| HBB | hemoglobin, beta | 3.65838 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 3.5263 |
| MXRA7 | matrix-remodelling associated 7 | 3.32265 |
| HBA1 | hemoglobin, alpha 1 | 3.29827 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 3.28373 |
| KDM5A | lysine (K)-specific demethylase 5A | 3.2562 |
| ZNF134 | zinc finger protein 134 | 3.1258 |
| NPIPB6 | nuclear pore complex interacting protein family, member B6 | 3.0627 |
| HLA-DRB3 | major histocompatibility complex, class II, DR beta 3 | 3.00975 |
| MAGEA11 | melanoma antigen family A11 | 2.9879 |
| LOC128966597 | MAL-like protein | 2.9136 |
| FBXO34 | F-box protein 34 | 2.8836 |
| SYNJ2BP | synaptojanin 2 binding protein | 2.7551 |
| CKB | creatine kinase, brain | 2.6405 |
| SMG5 | SMG5 nonsense mediated mRNA decay factor | 2.63958 |
| CYP2W1 | cytochrome P450, family 2, subfamily W, polypeptide 1 | 2.63935 |
| EPS8L2 | EPS8-like 2 | 2.58935 |
| GNL1 | guanine nucleotide binding protein-like 1 | 2.5213 |
| QPRT | quinolinate phosphoribosyltransferase | 2.5141 |
| DES | desmin | 2.50362 |
| KPNA3 | karyopherin alpha 3 (importin alpha 4) | 2.436 |
| TNXB | tenascin XB | 2.41331 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 2.40942 |
| C1QB | complement component 1, q subcomponent, B chain | 2.4051 |
| SH2D1A | SH2 domain containing 1A | 2.39915 |
| IL22RA1 | interleukin 22 receptor, alpha 1 | 2.3978 |
| CHFR | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | 2.39605 |
| CETP | cholesteryl ester transfer protein, plasma | 2.3949 |
| IL13RA2 | interleukin 13 receptor, alpha 2 | 2.39045 |
| NKX2-1 | NK2 homeobox 1 | 2.3846 |
| LOC105379278 | uncharacterized LOC105379278 | 2.3443 |
| SKAP2 | src kinase associated phosphoprotein 2 | 2.33272 |
| BARX2 | BARX homeobox 2 | 2.3216 |
| GATA4 | GATA binding protein 4 | 2.31475 |
| IGLL1 | immunoglobulin lambda-like polypeptide 1 | 2.29075 |
| TTK | TTK protein kinase | 2.27145 |
| APOA1 | apolipoprotein A-I | 2.2438 |
| PRSS8 | protease, serine, 8 | 2.24075 |
| NECAB3 | N-terminal EF-hand calcium binding protein 3 | 2.22145 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 2.21715 |
| SMAD7 | SMAD family member 7 | 2.20935 |
| ELMO3 | engulfment and cell motility 3 | 2.20405 |
| AGR2 | anterior gradient 2 | 2.1765 |
| DOK4 | docking protein 4 | 2.17388 |
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 | 2.17345 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.16402 |
| ACE2 | angiotensin I converting enzyme 2 | 2.14768 |
| KRI1 | KRI1 homolog (S. cerevisiae) | 2.1369 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | 2.135 |
| SAMD9 | sterile alpha motif domain containing 9 | 2.13 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 2.125 |
| ANKRD6 | ankyrin repeat domain 6 | 2.11923 |
| ZNF551 | zinc finger protein 551 | 2.10325 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 2.09955 |
| CAPN3 | calpain 3, (p94) | 2.09618 |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | 2.0866 |
| CENPE | centromere protein E, 312kDa | 2.08315 |
| YY1AP1 | YY1 associated protein 1 | 2.08245 |
| NUBPL | nucleotide binding protein-like | 2.0788 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 2.0754 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 2.0673 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 2.06345 |
| NDC80 | NDC80 kinetochore complex component | 2.06245 |
| NDNF | neuron-derived neurotrophic factor | 2.062 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 2.0616 |
| DUX4 | double homeobox 4 | 2.05595 |
| CDHR2 | cadherin-related family member 2 | 2.051 |
| GYS1 | glycogen synthase 1 (muscle) | 2.04655 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | 2.0341 |
| FRZB | frizzled-related protein | 2.0285 |
| CCL23 | chemokine (C-C motif) ligand 23 | 2.02305 |
| KANK2 | KN motif and ankyrin repeat domains 2 | 2.01505 |
| EFNA1 | ephrin-A1 | 2.0116 |
| CCNA1 | cyclin A1 | 2.00545 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TRAPPC3 | trafficking protein particle complex 3 | -8.26585 |
| KRT14 | keratin 14, type I | -6.39045 |
| HMG20B | high mobility group 20B | -4.91838 |
| MRPS15 | mitochondrial ribosomal protein S15 | -4.57155 |
| PRPF4 | pre-mRNA processing factor 4 | -4.36457 |
| COPS7A | COP9 signalosome subunit 7A | -3.8882 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -3.87875 |
| AGO1 | argonaute RISC catalytic component 1 | -3.7899 |
| MALT1 | MALT1 paracaspase | -3.64892 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -3.6488 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -3.5293 |
| GDF15 | growth differentiation factor 15 | -3.35145 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -3.27375 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -3.23162 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -3.0506 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -2.9659 |
| NISCH | nischarin | -2.9132 |
| ZMYM4 | zinc finger, MYM-type 4 | -2.89977 |
| MEAF6 | MYST/Esa1-associated factor 6 | -2.8809 |
| TLCD3A | TLC domain containing 3A | -2.83595 |
| GIGYF2 | GRB10 interacting GYF protein 2 | -2.77835 |
| COL8A2 | collagen, type VIII, alpha 2 | -2.77348 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | -2.7297 |
| TMEM268 | transmembrane protein 268 | -2.71095 |
| SIGLEC15 | sialic acid binding Ig-like lectin 15 | -2.6568 |
| TRIT1 | tRNA isopentenyltransferase 1 | -2.65375 |
| PLPP2 | phospholipid phosphatase 2 | -2.6511 |
| RIPOR2 | RHO family interacting cell polarization regulator 2 | -2.57118 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | -2.57095 |
| BSPRY | B-box and SPRY domain containing | -2.56495 |
| FAN1 | FANCD2/FANCI-associated nuclease 1 | -2.5606 |
| MOSPD2 | motile sperm domain containing 2 | -2.55867 |
| KIAA0319L | KIAA0319-like | -2.5365 |
| MSN | moesin | -2.52815 |
| YRDC | yrdC N(6)-threonylcarbamoyltransferase domain containing | -2.5237 |
| P3H1 | prolyl 3-hydroxylase 1 | -2.50575 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -2.501 |
| GNL2 | guanine nucleotide binding protein-like 2 (nucleolar) | -2.48355 |
| DNAJC7 | DnaJ (Hsp40) homolog, subfamily C, member 7 | -2.45335 |
| GTF2H4 | general transcription factor IIH, polypeptide 4, 52kDa | -2.40815 |
| MOGS | mannosyl-oligosaccharide glucosidase | -2.3771 |
| SF3A3 | splicing factor 3a, subunit 3, 60kDa | -2.359 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | -2.33895 |
| LOC102724594 | splicing factor U2AF 35 kDa subunit | -2.3269 |
| PARK7 | parkinson protein 7 | -2.3205 |
| ARAP3 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 | -2.30215 |
| CHPF2 | chondroitin polymerizing factor 2 | -2.28863 |
| MANF | mesencephalic astrocyte-derived neurotrophic factor | -2.26625 |
| ZYX | zyxin | -2.26318 |
| OGFOD1 | 2-oxoglutarate and iron-dependent oxygenase domain containing 1 | -2.2556 |
| RBM4B | RNA binding motif protein 4B | -2.2529 |
| TAF12 | TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa | -2.23575 |
| PSMB2 | proteasome (prosome, macropain) subunit, beta type, 2 | -2.23252 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | -2.2242 |
| NNAT | neuronatin | -2.20915 |
| POLE3 | polymerase (DNA directed), epsilon 3, accessory subunit | -2.20705 |
| CLASRP | CLK4-associating serine/arginine rich protein | -2.1993 |
| LOC128031832 | uncharacterized LOC128031832 | -2.1974 |
| CASD1 | CAS1 domain containing 1 | -2.1858 |
| NXT1 | nuclear transport factor 2-like export factor 1 | -2.17125 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | -2.16295 |
| MFSD1 | major facilitator superfamily domain containing 1 | -2.14445 |
| PLEKHS1 | pleckstrin homology domain containing, family S member 1 | -2.12865 |
| TMEM165 | transmembrane protein 165 | -2.12355 |
| RNF146 | ring finger protein 146 | -2.121 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | -2.11585 |
| MANBA | mannosidase, beta A, lysosomal | -2.1077 |
| AGO4 | argonaute RISC catalytic component 4 | -2.0911 |
| MYDGF | myeloid-derived growth factor | -2.07433 |
| RNF25 | ring finger protein 25 | -2.0725 |
| INPP5B | inositol polyphosphate-5-phosphatase, 75kDa | -2.06795 |
| EIF3I | eukaryotic translation initiation factor 3, subunit I | -2.0639 |
| TMEM230 | transmembrane protein 230 | -2.02635 |
| MGA | MGA, MAX dimerization protein | -2.02055 |
| GMCL1 | germ cell-less, spermatogenesis associated 1 | -2.0187 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 | -2.01715 |
| ACP2 | acid phosphatase 2, lysosomal | -2.0043 |
| BSG | basigin (Ok blood group) | -2.00415 |
