CRCGN017_MCF10A.WT.HP_24H:I18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description xylene mixture (60% m-xylene, 9% o-xylene, 14% p-xylene, 17% ethylbenzene) 10.76 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

22 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:I18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STAP2 signal transducing adaptor family member 2 2.6517
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.6435
SKIC8 SKI8 subunit of superkiller complex 2.0664
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.00075

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -5.0916
CCNB1 cyclin B1 -5.0634
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.728
PCCB propionyl CoA carboxylase, beta polypeptide -4.40995
RNF167 ring finger protein 167 -4.07515
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.69375
VDAC1 voltage-dependent anion channel 1 -3.63458
HEATR1 HEAT repeat containing 1 -3.5656
PARP2 poly (ADP-ribose) polymerase 2 -3.45938
TMEM50A transmembrane protein 50A -2.77525
NT5DC2 5'-nucleotidase domain containing 2 -2.7706
LIN37 lin-37 DREAM MuvB core complex component -2.59015
METTL17 methyltransferase like 17 -2.4634
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.3681
ARID4B AT rich interactive domain 4B (RBP1-like) -2.18045
SLC35G2 solute carrier family 35, member G2 -2.0491
BEGAIN brain-enriched guanylate kinase-associated -2.0093
FAIM Fas apoptotic inhibitory molecule -2.00715