CRCGN017_MCF10A.WT.HP_24H:J02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-chloro-p-phenylenediamine sulfate 33.27 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 6.34214
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.98453
TXNRD1 thioredoxin reductase 1 3.71359
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.30457
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.2824
UGDH UDP-glucose 6-dehydrogenase 3.04045
KLHL9 kelch-like family member 9 2.92314
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.5839
HMOX1 heme oxygenase 1 2.57404
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.56922
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.54554
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.49502
IGFBP3 insulin-like growth factor binding protein 3 2.11493
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.06743
FZD1 frizzled class receptor 1 2.06198

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -3.53128
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.50314
PCNA proliferating cell nuclear antigen -3.4432
CDC25B cell division cycle 25B -3.40722
VAT1 vesicle amine transport 1 -3.20721
OXA1L oxidase (cytochrome c) assembly 1-like -3.07881
HAT1 histone acetyltransferase 1 -3.00628
LYPLA1 lysophospholipase I -2.93567
CREG1 cellular repressor of E1A-stimulated genes 1 -2.89088
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.82753
ANKRD10 ankyrin repeat domain 10 -2.72252
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.63577
NLRP4 NLR family, pyrin domain containing 4 -2.44871
TES testin LIM domain protein -2.22606
CHD1 chromodomain helicase DNA binding protein 1 -2.14714
CDC20 cell division cycle 20 -2.03883
CD320 CD320 molecule -2.03658
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.02875