CRCGN017_MCF10A.WT.HP_24H:J03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-chloro-p-phenylenediamine sulfate 11.09 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

75 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 4.95969
COMP cartilage oligomeric matrix protein 4.28197
MAMLD1 mastermind-like domain containing 1 4.1688
UGDH UDP-glucose 6-dehydrogenase 3.67471
NBEA neurobeachin 3.02822
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.98818
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 2.84742
TBX2 T-box 2 2.84162
RFPL2 ret finger protein-like 2 2.66272
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 2.59837
FCHO1 FCH domain only 1 2.58977
FBXO11 F-box protein 11 2.5332
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.53114
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.51547
SOCS5 suppressor of cytokine signaling 5 2.43415
LTN1 listerin E3 ubiquitin protein ligase 1 2.34322
EPHB2 EPH receptor B2 2.24236
IL6 interleukin 6 2.22667
MSH2 mutS homolog 2 2.22262
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 2.22212
REG1B regenerating islet-derived 1 beta 2.212
RFPL3 ret finger protein-like 3 2.17747
PLAC1 placenta-specific 1 2.15035
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 2.14873
CLDN3 claudin 3 2.12825
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 2.12799
CNRIP1 cannabinoid receptor interacting protein 1 2.10765
ZNF85 zinc finger protein 85 2.08727
MINDY3 MINDY lysine 48 deubiquitinase 3 2.07944
RECK reversion-inducing-cysteine-rich protein with kazal motifs 2.07319
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 2.05746
PCDHGA10 protocadherin gamma subfamily A, 10 2.05284
FGF7 fibroblast growth factor 7 2.04754
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 2.0468
TAGLN3 transgelin 3 2.04154
GPATCH8 G patch domain containing 8 2.03974
PYGM phosphorylase, glycogen, muscle 2.03536
MRPL12 mitochondrial ribosomal protein L12 2.03361
DEFA6 defensin, alpha 6, Paneth cell-specific 2.03212
FZD7 frizzled class receptor 7 2.01573
SSUH2 ssu-2 homolog (C. elegans) 2.00494

decreased expression

Symbol Name Standardized Value
MRPS16 mitochondrial ribosomal protein S16 -5.90571
TNIP1 TNFAIP3 interacting protein 1 -5.76491
SLC35F2 solute carrier family 35, member F2 -5.16132
ACOT9 acyl-CoA thioesterase 9 -4.7143
FABP5 fatty acid binding protein 5 (psoriasis-associated) -4.59453
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.43065
TM9SF3 transmembrane 9 superfamily member 3 -4.03718
CD81 CD81 molecule -3.78013
KRT14 keratin 14, type I -3.09276
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.89361
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -2.82568
MSN moesin -2.71022
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.67529
CD58 CD58 molecule -2.63651
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.55238
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.5397
OXCT1 3-oxoacid CoA transferase 1 -2.49864
COPS7A COP9 signalosome subunit 7A -2.49368
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 -2.45265
DYNLRB1 dynein, light chain, roadblock-type 1 -2.28288
CHMP2A charged multivesicular body protein 2A -2.27428
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.2725
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -2.20121
PRR13 proline rich 13 -2.18911
GIPC1 GIPC PDZ domain containing family, member 1 -2.18647
GAA glucosidase, alpha; acid -2.14914
FCGRT Fc fragment of IgG, receptor, transporter, alpha -2.14748
ACAA1 acetyl-CoA acyltransferase 1 -2.13204
ZNF672 zinc finger protein 672 -2.12856
TLCD3A TLC domain containing 3A -2.12672
APOO apolipoprotein O -2.07586
CREG1 cellular repressor of E1A-stimulated genes 1 -2.05098
GNB5 guanine nucleotide binding protein (G protein), beta 5 -2.04044
COX7C cytochrome c oxidase subunit VIIc -2.00446