CRCGN017_MCF10A.WT.HP_24H:J04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitro-o-phenylenediamine 99.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

146 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 10.0
TXNRD1 thioredoxin reductase 1 8.8765
SSBP2 single-stranded DNA binding protein 2 5.75696
ABHD4 abhydrolase domain containing 4 5.6166
NUCB2 nucleobindin 2 5.27991
UGDH UDP-glucose 6-dehydrogenase 5.19208
GLRX glutaredoxin (thioltransferase) 4.89985
RAP1GAP RAP1 GTPase activating protein 4.16517
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.02142
LRP10 low density lipoprotein receptor-related protein 10 3.95526
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.80825
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 3.58399
COMP cartilage oligomeric matrix protein 3.45305
SQSTM1 sequestosome 1 3.43273
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 3.31941
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 3.24536
GCLM glutamate-cysteine ligase, modifier subunit 3.20903
CTSL cathepsin L 3.13311
FOXO4 forkhead box O4 3.08564
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 3.01329
NQO1 NAD(P)H dehydrogenase, quinone 1 2.98107
AGR2 anterior gradient 2 2.87909
NUPR1 nuclear protein, transcriptional regulator, 1 2.85457
CBR3 carbonyl reductase 3 2.78184
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.72737
TSKU tsukushi, small leucine rich proteoglycan 2.67709
BLVRB biliverdin reductase B 2.67368
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.66308
NPC1 Niemann-Pick disease, type C1 2.61999
AKR1C3 aldo-keto reductase family 1, member C3 2.61834
PCDHB16 protocadherin beta 16 2.61724
OSGIN1 oxidative stress induced growth inhibitor 1 2.58163
TALDO1 transaldolase 1 2.57777
C1S complement component 1, s subcomponent 2.57707
C1R complement component 1, r subcomponent 2.55904
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.54923
SYNE2 spectrin repeat containing, nuclear envelope 2 2.5453
PRSS8 protease, serine, 8 2.5017
CDPF1 cysteine-rich, DPF motif domain containing 1 2.45632
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.44098
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.43934
AKR1C1 aldo-keto reductase family 1, member C1 2.43742
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.43498
EPHB2 EPH receptor B2 2.41958
DSTN destrin (actin depolymerizing factor) 2.3926
ETFB electron-transfer-flavoprotein, beta polypeptide 2.34018
CARMIL1 capping protein regulator and myosin 1 linker 1 2.33569
SEC24C SEC24 family member C 2.32652
SLC35B1 solute carrier family 35, member B1 2.32429
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 2.30783
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 2.28843
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 2.28569
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.28388
GABARAPL1 GABA(A) receptor-associated protein like 1 2.28218
GPX2 glutathione peroxidase 2 2.27382
MVP major vault protein 2.25789
TRIM16 tripartite motif containing 16 2.23413
CNRIP1 cannabinoid receptor interacting protein 1 2.20964
MSRB1 methionine sulfoxide reductase B1 2.18396
LLGL2 lethal giant larvae homolog 2 (Drosophila) 2.17949
IPP intracisternal A particle-promoted polypeptide 2.17666
ZNF646 zinc finger protein 646 2.17662
MAP7 microtubule-associated protein 7 2.1763
DDB1 damage-specific DNA binding protein 1, 127kDa 2.17019
AKTIP AKT interacting protein 2.16961
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.16442
TOM1 target of myb1 (chicken) 2.16192
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 2.14691
ESRP2 epithelial splicing regulatory protein 2 2.13394
PIR pirin (iron-binding nuclear protein) 2.13263
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 2.11388
KEAP1 kelch-like ECH-associated protein 1 2.0944
CYB5A cytochrome b5 type A (microsomal) 2.09382
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.08608
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 2.07722
GCLC glutamate-cysteine ligase, catalytic subunit 2.07049
NR1H3 nuclear receptor subfamily 1, group H, member 3 2.07038
GSR glutathione reductase 2.06398
BORCS6 BLOC-1 related complex subunit 6 2.06271
SMIM40 small integral membrane protein 40 2.06266
HDAC7 histone deacetylase 7 2.05899
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.04696
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.01424

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -7.33856
CDC45 cell division cycle 45 -4.60261
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -4.19876
ACOT9 acyl-CoA thioesterase 9 -4.17689
FABP5 fatty acid binding protein 5 (psoriasis-associated) -4.16793
STMN1 stathmin 1 -4.13233
RPIA ribose 5-phosphate isomerase A -3.93642
CCNB1 cyclin B1 -3.7866
CAB39 calcium binding protein 39 -3.64168
HMG20B high mobility group 20B -3.3171
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -3.17965
DCK deoxycytidine kinase -2.97465
NUP85 nucleoporin 85kDa -2.95681
MAK16 MAK16 homolog (S. cerevisiae) -2.91282
CDK4 cyclin-dependent kinase 4 -2.90823
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.88007
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.79795
TNIP1 TNFAIP3 interacting protein 1 -2.78496
MSN moesin -2.78393
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.74959
AK6 adenylate kinase 6 -2.70628
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.68094
CDK1 cyclin-dependent kinase 1 -2.67707
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -2.63885
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.60295
WDR3 WD repeat domain 3 -2.57992
CD320 CD320 molecule -2.53176
RUVBL1 RuvB-like AAA ATPase 1 -2.51456
MRPS17 mitochondrial ribosomal protein S17 -2.43228
RFC3 replication factor C (activator 1) 3, 38kDa -2.39727
HAUS7 HAUS augmin-like complex, subunit 7 -2.38718
TRIP13 thyroid hormone receptor interactor 13 -2.38702
EGR1 early growth response 1 -2.37559
NUSAP1 nucleolar and spindle associated protein 1 -2.37167
TEX10 testis expressed 10 -2.34229
CDCA4 cell division cycle associated 4 -2.32569
IFRD2 interferon-related developmental regulator 2 -2.26643
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.23295
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -2.23057
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.21354
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.21342
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.21021
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 -2.19974
KIF4A kinesin family member 4A -2.19417
NOL11 nucleolar protein 11 -2.18111
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -2.17261
VIM vimentin -2.16718
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.13987
CDC23 cell division cycle 23 -2.11645
MCM3 minichromosome maintenance complex component 3 -2.11592
POGLUT2 protein O-glucosyltransferase 2 -2.09644
TOP2A topoisomerase (DNA) II alpha 170kDa -2.09332
TMEM120B transmembrane protein 120B -2.08467
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.05725
HMG20A high mobility group 20A -2.05219
PLP1 proteolipid protein 1 -2.04187
LAS1L LAS1-like (S. cerevisiae) -2.04184
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -2.02577
NUP107 nucleoporin 107kDa -2.02526
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.01918
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -2.01517
SLC35F2 solute carrier family 35, member F2 -2.00637
PFAS phosphoribosylformylglycinamidine synthase -2.00091