CRCGN017_MCF10A.WT.HP_24H:J05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitro-o-phenylenediamine 33.27 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 8.18458
TXNRD1 thioredoxin reductase 1 7.27485
UGDH UDP-glucose 6-dehydrogenase 5.21275
CNRIP1 cannabinoid receptor interacting protein 1 3.87924
GLRX glutaredoxin (thioltransferase) 3.84644
BMP4 bone morphogenetic protein 4 3.75051
METRN meteorin, glial cell differentiation regulator 3.51212
GCLM glutamate-cysteine ligase, modifier subunit 3.42247
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.37825
ABHD4 abhydrolase domain containing 4 3.14247
MCOLN1 mucolipin 1 3.13324
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.98344
SQSTM1 sequestosome 1 2.97611
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.85357
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.8001
GCLC glutamate-cysteine ligase, catalytic subunit 2.72923
TRIM16 tripartite motif containing 16 2.68171
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.55341
NUCB2 nucleobindin 2 2.46904
NQO1 NAD(P)H dehydrogenase, quinone 1 2.41283
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.40158
COMP cartilage oligomeric matrix protein 2.26458
GSR glutathione reductase 2.25922
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.23428
INSIG1 insulin induced gene 1 2.20122
LRP10 low density lipoprotein receptor-related protein 10 2.18319
STK10 serine/threonine kinase 10 2.16435
OSGIN1 oxidative stress induced growth inhibitor 1 2.15206
RAP1GAP RAP1 GTPase activating protein 2.13513
HADH hydroxyacyl-CoA dehydrogenase 2.11946
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.10352
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.07151
CES1 carboxylesterase 1 2.06356
CBR3 carbonyl reductase 3 2.04685
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 2.03215
MINDY1 MINDY lysine 48 deubiquitinase 1 2.0257

decreased expression

Symbol Name Standardized Value
TUBB6 tubulin, beta 6 class V -3.88702
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.65767
CD320 CD320 molecule -3.28842
HEATR1 HEAT repeat containing 1 -3.25903
TXNDC9 thioredoxin domain containing 9 -3.03319
CHIC2 cysteine-rich hydrophobic domain 2 -2.93803
KRT14 keratin 14, type I -2.77338
TLCD3A TLC domain containing 3A -2.63158
PES1 pescadillo ribosomal biogenesis factor 1 -2.42391
ATG3 autophagy related 3 -2.29773
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.21042
NLE1 notchless homolog 1 (Drosophila) -2.16594
POLR1G RNA polymerase I subunit G -2.12041
NAT10 N-acetyltransferase 10 (GCN5-related) -2.04642