CRCGN017_MCF10A.WT.HP_24H:J07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxytetracycline.hcl 99.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

593 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 9.37935
GFPT1 glutamine--fructose-6-phosphate transaminase 1 8.37087
PYCR1 pyrroline-5-carboxylate reductase 1 7.4297
AARS1 alanyl-tRNA synthetase 1 6.64925
AGR2 anterior gradient 2 6.6486
GLRX glutaredoxin (thioltransferase) 6.4611
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 6.23975
TXNRD1 thioredoxin reductase 1 6.1098
PSAT1 phosphoserine aminotransferase 1 6.0457
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 5.91385
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 5.7143
CARS1 cysteinyl-tRNA synthetase 1 5.67392
LOXL1 lysyl oxidase-like 1 5.64945
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 5.5041
FYN FYN proto-oncogene, Src family tyrosine kinase 5.25568
GARS1 glycyl-tRNA synthetase 1 5.25465
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 5.0245
PHGDH phosphoglycerate dehydrogenase 4.98667
XPOT exportin, tRNA 4.9442
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 4.91278
WIF1 WNT inhibitory factor 1 4.8413
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 4.80222
GRB10 growth factor receptor-bound protein 10 4.77583
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 4.73265
CNPY3 canopy FGF signaling regulator 3 4.66725
CTSL cathepsin L 4.62605
TRIB3 tribbles pseudokinase 3 4.6099
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 4.55175
ATF4 activating transcription factor 4 4.5458
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.4665
LOC128125814 uncharacterized LOC128125814 4.42555
MOK MOK protein kinase 4.33855
YARS1 tyrosyl-tRNA synthetase 1 4.31805
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 4.27647
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 4.16335
TBX2 T-box 2 4.15232
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.10785
VSIG2 V-set and immunoglobulin domain containing 2 4.08715
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 4.07635
STX1A syntaxin 1A (brain) 4.0166
EPRS1 glutamyl-prolyl-tRNA synthetase 1 4.01345
TARS1 threonyl-tRNA synthetase 1 3.99025
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.9843
FHL2 four and a half LIM domains 2 3.8924
NUCB2 nucleobindin 2 3.87535
STC2 stanniocalcin 2 3.87263
NARS1 asparaginyl-tRNA synthetase 1 3.87215
COPB1 coatomer protein complex, subunit beta 1 3.82553
MARS1 methionyl-tRNA synthetase 1 3.81703
HAX1 HCLS1 associated protein X-1 3.7904
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.78725
KCTD5 potassium channel tetramerization domain containing 5 3.78445
TWF2 twinfilin actin binding protein 2 3.75515
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 3.75135
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 3.74545
LRP10 low density lipoprotein receptor-related protein 10 3.6832
CHMP4B charged multivesicular body protein 4B 3.56282
SLC35B1 solute carrier family 35, member B1 3.50525
ASNS asparagine synthetase (glutamine-hydrolyzing) 3.4835
CHIC2 cysteine-rich hydrophobic domain 2 3.46705
LARP6 La ribonucleoprotein domain family, member 6 3.4437
SARS1 seryl-tRNA synthetase 1 3.4332
SIRT3 sirtuin 3 3.42125
ATF6 activating transcription factor 6 3.40715
ACAA1 acetyl-CoA acyltransferase 1 3.37782
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 3.3708
CLIC4 chloride intracellular channel 4 3.35128
TES testin LIM domain protein 3.33735
HMOX1 heme oxygenase 1 3.31185
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 3.29135
ERP29 endoplasmic reticulum protein 29 3.2337
ECH1 enoyl CoA hydratase 1, peroxisomal 3.204
PTPN6 protein tyrosine phosphatase, non-receptor type 6 3.19325
TBL1X transducin (beta)-like 1X-linked 3.1751
CORO1A coronin, actin binding protein, 1A 3.1663
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.11175
METTL25B methyltransferase like 25B 3.06115
GOLT1A golgi transport 1A 3.0135
INHBE inhibin, beta E 2.9945
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 2.9834
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 2.9689
UNC5B unc-5 homolog B (C. elegans) 2.9618
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough 2.9577
P3H1 prolyl 3-hydroxylase 1 2.94695
NPY5R neuropeptide Y receptor Y5 2.91765
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2.91075
TM9SF3 transmembrane 9 superfamily member 3 2.8957
NPDC1 neural proliferation, differentiation and control, 1 2.8863
GSTZ1 glutathione S-transferase zeta 1 2.87225
SQSTM1 sequestosome 1 2.85985
ZCCHC8 zinc finger, CCHC domain containing 8 2.8564
CZIB CXXC motif containing zinc binding protein 2.8516
NAT9 N-acetyltransferase 9 (GCN5-related, putative) 2.8476
CCDC92 coiled-coil domain containing 92 2.84665
GMPPA GDP-mannose pyrophosphorylase A 2.83945
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 2.8271
GOLGA3 golgin A3 2.81935
TAOK3 TAO kinase 3 2.80915
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 2.80625
IFT88 intraflagellar transport 88 2.7515
MSRA methionine sulfoxide reductase A 2.751
CANT1 calcium activated nucleotidase 1 2.74633
GAA glucosidase, alpha; acid 2.7461
ZMYM2 zinc finger, MYM-type 2 2.73455
TRIM8 tripartite motif containing 8 2.7092
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.70823
NLRP4 NLR family, pyrin domain containing 4 2.70345
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 2.6904
UNC13D unc-13 homolog D (C. elegans) 2.68505
CCS copper chaperone for superoxide dismutase 2.6818
TESC tescalcin 2.6699
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.66525
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) 2.66477
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 2.6559
NUPR1 nuclear protein, transcriptional regulator, 1 2.6346
BCAS3 breast carcinoma amplified sequence 3 2.62035
SCCPDH saccharopine dehydrogenase (putative) 2.61943
SPATA20 spermatogenesis associated 20 2.6164
PLEC plectin 2.61443
ATXN2 ataxin 2 2.5876
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 2.58205
RIOX2 ribosomal oxygenase 2 2.57855
CAMTA2 calmodulin binding transcription activator 2 2.5731
SLC67A1 solute carrier family 67 member 1 2.5692
COG5 component of oligomeric golgi complex 5 2.56658
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 2.56572
IFRD1 interferon-related developmental regulator 1 2.5473
MAGED2 melanoma antigen family D2 2.54503
TALDO1 transaldolase 1 2.53615
SMIM10L1 small integral membrane protein 10 like 1 2.52425
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 2.52352
ZPR1 ZPR1 zinc finger 2.50985
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 2.4818
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 2.4811
TSG101 tumor susceptibility 101 2.4806
NADSYN1 NAD synthetase 1 2.46875
TMEM94 transmembrane protein 94 2.46525
STIMATE STIM activating enhancer 2.4651
TFF2 trefoil factor 2 2.4647
STYXL1 serine/threonine/tyrosine interacting-like 1 2.4562
FNDC4 fibronectin type III domain containing 4 2.45555
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.44865
CALU calumenin 2.44216
STN1 STN1 subunit of CST complex 2.4396
SPX spexin hormone 2.43835
BUD31 BUD31 homolog (S. cerevisiae) 2.42615
ZNF281 zinc finger protein 281 2.4212
VPS9D1 VPS9 domain containing 1 2.42115
RBKS ribokinase 2.41937
FICD FIC domain containing 2.41705
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.4168
TBCB tubulin folding cofactor B 2.41638
ITCH itchy E3 ubiquitin protein ligase 2.4156
CCNA1 cyclin A1 2.41525
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.4011
SCRG1 stimulator of chondrogenesis 1 2.3693
LIN7A lin-7 homolog A (C. elegans) 2.3571
RMDN1 regulator of microtubule dynamics 1 2.3568
TM9SF2 transmembrane 9 superfamily member 2 2.34705
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.3393
IL21R interleukin 21 receptor 2.336
MAN2A1 mannosidase, alpha, class 2A, member 1 2.33285
DENR density-regulated protein 2.32805
NGLY1 N-glycanase 1 2.31655
GCC1 GRIP and coiled-coil domain containing 1 2.3156
PRAF2 PRA1 domain family, member 2 2.30245
GORASP2 golgi reassembly stacking protein 2, 55kDa 2.297
FOXO4 forkhead box O4 2.2879
CETP cholesteryl ester transfer protein, plasma 2.28715
ZDHHC14 zinc finger, DHHC-type containing 14 2.2863
ANKZF1 ankyrin repeat and zinc finger domain containing 1 2.2788
LOC124907782 dual specificity protein phosphatase 22 2.26975
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.2686
TMEM59 transmembrane protein 59 2.26765
IGF2R insulin-like growth factor 2 receptor 2.26745
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 2.2646
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.26358
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 2.2586
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 2.2347
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 2.22975
BGN biglycan 2.22878
PIEZO2 piezo-type mechanosensitive ion channel component 2 2.22545
VEGFC vascular endothelial growth factor C 2.2247
ATRAID all-trans retinoic acid-induced differentiation factor 2.2185
WARS1 tryptophanyl-tRNA synthetase 1 2.21845
SNX6 sorting nexin 6 2.2181
ZBTB35 zinc finger and BTB domain containing 35 2.21318
KCTD11 potassium channel tetramerization domain containing 11 2.21245
G0S2 G0/G1 switch 2 2.20985
PPCS phosphopantothenoylcysteine synthetase 2.2082
IFT20 intraflagellar transport 20 2.20475
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.19985
LOC102724560 cystathionine beta-synthase 2.19975
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 2.19855
GID4 GID complex subunit 4 2.19745
ZFPM1 zinc finger protein, FOG family member 1 2.1914
SCMH1 sex comb on midleg homolog 1 (Drosophila) 2.19025
MID1IP1 MID1 interacting protein 1 2.18895
CRAT carnitine O-acetyltransferase 2.1844
NPIPB5 nuclear pore complex interacting protein family, member B5 2.18415
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.1816
GFUS GDP-L-fucose synthase 2.1807
OSGIN1 oxidative stress induced growth inhibitor 1 2.17825
HDLBP high density lipoprotein binding protein 2.17592
RHOG ras homolog family member G 2.17555
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 2.17535
MEA1 male-enhanced antigen 1 2.16425
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2.1598
HOXB13 homeobox B13 2.15965
PCCB propionyl CoA carboxylase, beta polypeptide 2.1579
LETMD1 LETM1 domain containing 1 2.15725
EEIG1 estrogen-induced osteoclastogenesis regulator 1 2.13615
ITGA10 integrin, alpha 10 2.13055
PHF21A PHD finger protein 21A 2.1297
GMFG glia maturation factor, gamma 2.12845
ZNF419 zinc finger protein 419 2.1283
CEMIP cell migration inducing protein, hyaluronan binding 2.12555
EIF2D eukaryotic translation initiation factor 2D 2.1173
MTIF2 mitochondrial translational initiation factor 2 2.11695
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 2.11475
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.1146
TGFBI transforming growth factor, beta-induced, 68kDa 2.11405
IER3 immediate early response 3 2.1058
STXBP2 syntaxin binding protein 2 2.0955
CUL7 cullin 7 2.09008
RNF187 ring finger protein 187 2.08665
GTPBP2 GTP binding protein 2 2.0862
UBQLN2 ubiquilin 2 2.0796
RPN1 ribophorin I 2.07355
MRPL57 mitochondrial ribosomal protein L57 2.07328
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 2.06915
TTC4 tetratricopeptide repeat domain 4 2.068
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.06585
UFM1 ubiquitin-fold modifier 1 2.0644
MUS81 MUS81 structure-specific endonuclease subunit 2.0643
XYLT1 xylosyltransferase I 2.06255
ELL2 elongation factor, RNA polymerase II, 2 2.06095
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.05925
INTS3 integrator complex subunit 3 2.05785
GDF5 growth differentiation factor 5 2.0568
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2.05492
WWC3 WWC family member 3 2.05405
PYGB phosphorylase, glycogen; brain 2.0505
EXD2 exonuclease 3'-5' domain containing 2 2.047
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.04285
SRP19 signal recognition particle 19kDa 2.03928
OLAH oleoyl-ACP hydrolase 2.0389
RLIM ring finger protein, LIM domain interacting 2.03535
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.03445
AGTPBP1 ATP/GTP binding protein 1 2.03205
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.03205
PABPC3 poly(A) binding protein, cytoplasmic 3 2.0253
OARD1 O-acyl-ADP-ribose deacylase 1 2.0214
DYNLT3 dynein, light chain, Tctex-type 3 2.0169
ESYT1 extended synaptotagmin-like protein 1 2.01275
SPATA2L spermatogenesis associated 2-like 2.0093
ACTMAP actin maturation protease 2.00695
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 2.00355
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 2.00315
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.00292
NRBF2 nuclear receptor binding factor 2 2.00245
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 2.0012
HSPA13 heat shock protein 70kDa family, member 13 2.0008
LOC124900388 uncharacterized LOC124900388 2.00075

decreased expression

Symbol Name Standardized Value
PSRC1 proline/serine-rich coiled-coil 1 -6.56405
CDC20 cell division cycle 20 -6.32265
CDK1 cyclin-dependent kinase 1 -6.27412
STMN1 stathmin 1 -6.0505
KRT14 keratin 14, type I -6.01545
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -5.94805
UBE2C ubiquitin-conjugating enzyme E2C -5.8645
TUBB6 tubulin, beta 6 class V -5.808
CDC45 cell division cycle 45 -5.6561
PRPF4 pre-mRNA processing factor 4 -5.53172
HMG20B high mobility group 20B -5.47878
MT2A metallothionein 2A -5.3421
MSMO1 methylsterol monooxygenase 1 -5.32605
ASF1B anti-silencing function 1B histone chaperone -5.30445
OAT ornithine aminotransferase -5.12745
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.04605
INSIG1 insulin induced gene 1 -5.01577
SGK1 serum/glucocorticoid regulated kinase 1 -5.0
S100A8 S100 calcium binding protein A8 -5.0
SMNDC1 survival motor neuron domain containing 1 -4.9075
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -4.72345
CCNB2 cyclin B2 -4.68335
YME1L1 YME1-like 1 ATPase -4.65872
RGS2 regulator of G-protein signaling 2 -4.65545
AURKB aurora kinase B -4.4471
DCK deoxycytidine kinase -4.40505
PLK1 polo-like kinase 1 -4.3942
PCNA proliferating cell nuclear antigen -4.3631
GINS2 GINS complex subunit 2 (Psf2 homolog) -4.2883
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.2626
VAT1 vesicle amine transport 1 -4.26065
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.2121
KIF20A kinesin family member 20A -4.20955
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -4.14105
TMEM109 transmembrane protein 109 -4.07775
CCNA2 cyclin A2 -4.073
BIRC5 baculoviral IAP repeat containing 5 -4.01368
FEN1 flap structure-specific endonuclease 1 -3.92105
KIF18B kinesin family member 18B -3.8559
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -3.81445
HSPB1 heat shock 27kDa protein 1 -3.8095
MCM10 minichromosome maintenance complex component 10 -3.8065
CHAF1A chromatin assembly factor 1, subunit A (p150) -3.72403
ARID4B AT rich interactive domain 4B (RBP1-like) -3.6756
GMNN geminin, DNA replication inhibitor -3.63653
CCNB1 cyclin B1 -3.62665
TOP2A topoisomerase (DNA) II alpha 170kDa -3.6138
PRR15L proline rich 15-like -3.59845
CRYZ crystallin, zeta (quinone reductase) -3.54985
ERCC6L excision repair cross-complementation group 6-like -3.5301
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -3.52825
PMM2 phosphomannomutase 2 -3.52675
KIF11 kinesin family member 11 -3.5169
ZDHHC6 zinc finger, DHHC-type containing 6 -3.45475
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.4472
ALDOC aldolase C, fructose-bisphosphate -3.4316
NUP93 nucleoporin 93kDa -3.42895
GINS3 GINS complex subunit 3 (Psf3 homolog) -3.39433
SESN1 sestrin 1 -3.3938
RFC3 replication factor C (activator 1) 3, 38kDa -3.38928
S100A4 S100 calcium binding protein A4 -3.37695
CDC6 cell division cycle 6 -3.37523
ANXA2 annexin A2 -3.36778
NUSAP1 nucleolar and spindle associated protein 1 -3.3411
SPC25 SPC25, NDC80 kinetochore complex component -3.3204
TRIP13 thyroid hormone receptor interactor 13 -3.292
IDI1 isopentenyl-diphosphate delta isomerase 1 -3.27868
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.27755
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.2763
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -3.2605
GINS1 GINS complex subunit 1 (Psf1 homolog) -3.23725
PBK PDZ binding kinase -3.1983
NCAPH non-SMC condensin I complex, subunit H -3.1454
MT1X metallothionein 1X -3.14485
CDK2 cyclin-dependent kinase 2 -3.1402
PRC1 protein regulator of cytokinesis 1 -3.1103
TROAP trophinin associated protein -3.1003
CD320 CD320 molecule -3.0988
CPNE3 copine III -3.09705
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -3.0963
NMU neuromedin U -3.09485
TK1 thymidine kinase 1, soluble -3.0912
FIRRM FIGNL1 interacting regulator of recombination and mitosis -3.08235
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -3.07717
EXO1 exonuclease 1 -3.058
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.01945
HOXA5 homeobox A5 -3.0066
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -3.0055
OIP5 Opa interacting protein 5 -3.00025
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -2.99818
CCNF cyclin F -2.9977
EMP2 epithelial membrane protein 2 -2.9863
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.98257
KIF4A kinesin family member 4A -2.96855
RBL1 retinoblastoma-like 1 -2.9668
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.963
DEPDC1 DEP domain containing 1 -2.9526
FMR1 fragile X mental retardation 1 -2.95198
CYCS cytochrome c, somatic -2.9441
NCAPD2 non-SMC condensin I complex, subunit D2 -2.9436
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -2.9434
RMI1 RecQ mediated genome instability 1 -2.92835
HSPA14 heat shock 70kDa protein 14 -2.9249
BZW2 basic leucine zipper and W2 domains 2 -2.9187
SHPK sedoheptulokinase -2.9131
SERHL2 serine hydrolase-like 2 -2.9016
SNRPA1 small nuclear ribonucleoprotein polypeptide A' -2.8975
DCAF15 DDB1 and CUL4 associated factor 15 -2.89688
NEK2 NIMA-related kinase 2 -2.87687
PIMREG PICALM interacting mitotic regulator -2.8683
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.8663
CDCA8 cell division cycle associated 8 -2.8623
BICD2 bicaudal D homolog 2 (Drosophila) -2.84305
SNRPA small nuclear ribonucleoprotein polypeptide A -2.84275
ELOVL6 ELOVL fatty acid elongase 6 -2.83575
ACYP1 acylphosphatase 1, erythrocyte (common) type -2.83505
CAV2 caveolin 2 -2.83305
ZWINT ZW10 interacting kinetochore protein -2.81255
VBP1 von Hippel-Lindau binding protein 1 -2.8009
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.78199
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.77785
CAV1 caveolin 1, caveolae protein, 22kDa -2.7769
CENPC centromere protein C -2.77565
MCM5 minichromosome maintenance complex component 5 -2.77437
FOXM1 forkhead box M1 -2.75205
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.751
KIF18A kinesin family member 18A -2.74975
ARHGAP11A Rho GTPase activating protein 11A -2.7487
MTPAP mitochondrial poly(A) polymerase -2.7439
CENPM centromere protein M -2.74305
CTSO cathepsin O -2.7428
ADRB2 adrenoceptor beta 2, surface -2.7426
KIF14 kinesin family member 14 -2.72695
PGAM4 phosphoglycerate mutase family member 4 -2.6966
AURKA aurora kinase A -2.68593
CENPI centromere protein I -2.6731
NUP85 nucleoporin 85kDa -2.6707
SMC4 structural maintenance of chromosomes 4 -2.66053
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.65915
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.6577
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -2.6556
PDGFRL platelet-derived growth factor receptor-like -2.64385
MSN moesin -2.6288
ANGPTL7 angiopoietin-like 7 -2.6228
TCEAL9 transcription elongation factor A like 9 -2.6128
MAB21L1 mab-21-like 1 (C. elegans) -2.60315
CEP55 centrosomal protein 55kDa -2.59965
DNA2 DNA replication helicase/nuclease 2 -2.59865
NCAPG2 non-SMC condensin II complex, subunit G2 -2.5923
FGFBP1 fibroblast growth factor binding protein 1 -2.58745
MCM7 minichromosome maintenance complex component 7 -2.57612
MCMBP minichromosome maintenance complex binding protein -2.57435
BRD7 bromodomain containing 7 -2.56915
MSH2 mutS homolog 2 -2.56315
WDR76 WD repeat domain 76 -2.5563
SPAG5 sperm associated antigen 5 -2.55295
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -2.5486
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.5452
KRT13 keratin 13, type I -2.54455
DSCC1 DNA replication and sister chromatid cohesion 1 -2.5425
ZNF813 zinc finger protein 813 -2.5408
FANCI Fanconi anemia, complementation group I -2.5339
HAUS3 HAUS augmin-like complex, subunit 3 -2.53335
DUOX1 dual oxidase 1 -2.51347
KIF15 kinesin family member 15 -2.51115
MREG melanoregulin -2.5085
RTL8C retrotransposon Gag like 8C -2.49765
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.479
ACLY ATP citrate lyase -2.47768
SNX7 sorting nexin 7 -2.4767
SPDL1 spindle apparatus coiled-coil protein 1 -2.47415
RAD51 RAD51 recombinase -2.47032
TDRD7 tudor domain containing 7 -2.47015
CDT1 chromatin licensing and DNA replication factor 1 -2.4698
TTI2 TELO2 interacting protein 2 -2.46845
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.4633
KCTD9 potassium channel tetramerization domain containing 9 -2.4507
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa -2.45062
CDKN2AIP CDKN2A interacting protein -2.4432
RPA3 replication protein A3, 14kDa -2.4405
DENND2D DENN/MADD domain containing 2D -2.4402
FAM13A family with sequence similarity 13, member A -2.43888
CBR3 carbonyl reductase 3 -2.43875
POLK polymerase (DNA directed) kappa -2.43745
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.42988
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) -2.42825
JAG2 jagged 2 -2.42738
SH3D19 SH3 domain containing 19 -2.4273
HMGB3 high mobility group box 3 -2.4227
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide -2.42115
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.4196
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.41665
LPL lipoprotein lipase -2.41237
MAB21L2 mab-21-like 2 (C. elegans) -2.3932
ERI2 ERI1 exoribonuclease family member 2 -2.3929
RAD51AP1 RAD51 associated protein 1 -2.3909
CRABP2 cellular retinoic acid binding protein 2 -2.3851
SRSF3 serine/arginine-rich splicing factor 3 -2.38182
FAT2 FAT atypical cadherin 2 -2.3815
BAG3 BCL2-associated athanogene 3 -2.3809
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -2.38025
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13 -2.37779
DSN1 DSN1, MIS12 kinetochore complex component -2.3755
PSMC3IP PSMC3 interacting protein -2.37415
LYPD3 LY6/PLAUR domain containing 3 -2.3735
E2F8 E2F transcription factor 8 -2.36815
YJU2 YJU2 splicing factor homolog -2.36675
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -2.36193
LGALS9C lectin, galactoside-binding, soluble, 9C -2.35585
RABL6 RAB, member RAS oncogene family-like 6 -2.35485
NASP nuclear autoantigenic sperm protein (histone-binding) -2.35435
KIF22 kinesin family member 22 -2.35142
POLD3 polymerase (DNA-directed), delta 3, accessory subunit -2.3467
SHCBP1 SHC SH2-domain binding protein 1 -2.345
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type -2.34273
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -2.3427
MRPL44 mitochondrial ribosomal protein L44 -2.34185
PARP2 poly (ADP-ribose) polymerase 2 -2.33285
ARHGAP8 Rho GTPase activating protein 8 -2.33122
HROB homologous recombination factor with OB-fold -2.3284
TMEM51 transmembrane protein 51 -2.32805
ZMYM1 zinc finger, MYM-type 1 -2.32375
BTBD2 BTB (POZ) domain containing 2 -2.3225
HMGN2 high mobility group nucleosomal binding domain 2 -2.3215
TYRP1 tyrosinase-related protein 1 -2.31785
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -2.3127
NDC80 NDC80 kinetochore complex component -2.3032
SRSF2 serine/arginine-rich splicing factor 2 -2.3021
MKI67 marker of proliferation Ki-67 -2.29862
TMEM255A transmembrane protein 255A -2.29805
MFAP1 microfibrillar-associated protein 1 -2.2974
JPT2 Jupiter microtubule associated homolog 2 -2.29572
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.29045
RAD51C RAD51 paralog C -2.28958
NOTCH1 notch 1 -2.2843
TTC33 tetratricopeptide repeat domain 33 -2.28395
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -2.27475
GPR143 G protein-coupled receptor 143 -2.27295
MIS18A MIS18 kinetochore protein A -2.27295
NT5DC2 5'-nucleotidase domain containing 2 -2.26595
EXOSC9 exosome component 9 -2.2648
GCG glucagon -2.26125
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -2.25085
CDC25A cell division cycle 25A -2.2491
BRCA1 breast cancer 1, early onset -2.2444
KLHDC8A kelch domain containing 8A -2.24315
GPD1L glycerol-3-phosphate dehydrogenase 1-like -2.24085
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.2384
TLR3 toll-like receptor 3 -2.2353
TCERG1 transcription elongation regulator 1 -2.22515
WDHD1 WD repeat and HMG-box DNA binding protein 1 -2.22155
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.21715
CENPX centromere protein X -2.2138
ABHD17A abhydrolase domain containing 17A -2.2123
PARPBP PARP1 binding protein -2.20855
AKAP12 A kinase (PRKA) anchor protein 12 -2.20855
FKTN fukutin -2.2057
RAB33B RAB33B, member RAS oncogene family -2.2052
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.1968
ZNF557 zinc finger protein 557 -2.1836
GEMIN4 gem (nuclear organelle) associated protein 4 -2.18128
SRRM1 serine/arginine repetitive matrix 1 -2.17637
VRK1 vaccinia related kinase 1 -2.1693
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -2.16835
MORC3 MORC family CW-type zinc finger 3 -2.16515
NCAPG non-SMC condensin I complex, subunit G -2.15905
ACP5 acid phosphatase 5, tartrate resistant -2.15725
MCM3 minichromosome maintenance complex component 3 -2.15595
DHRS11 dehydrogenase/reductase (SDR family) member 11 -2.15505
CENPN centromere protein N -2.1538
MEGF9 multiple EGF-like-domains 9 -2.14845
SPRR1B small proline-rich protein 1B -2.14585
BORA bora, aurora kinase A activator -2.14435
PTTG1 pituitary tumor-transforming 1 -2.13855
PLK4 polo-like kinase 4 -2.13803
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.1351
RRAGB Ras-related GTP binding B -2.1349
TUBB4B tubulin, beta 4B class IVb -2.13245
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.1279
CCNC cyclin C -2.1253
TTF1 transcription termination factor, RNA polymerase I -2.12095
TMPO thymopoietin -2.12087
CENPQ centromere protein Q -2.11495
MT1E metallothionein 1E -2.11435
BTG3 BTG family, member 3 -2.11413
PARP1 poly (ADP-ribose) polymerase 1 -2.11395
TRIP10 thyroid hormone receptor interactor 10 -2.11325
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -2.1073
SETMAR SET domain and mariner transposase fusion gene -2.10245
GPRC5A G protein-coupled receptor, class C, group 5, member A -2.09705
ABHD10 abhydrolase domain containing 10 -2.09655
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -2.0961
CLCA2 chloride channel accessory 2 -2.09515
LBR lamin B receptor -2.08735
KANK1 KN motif and ankyrin repeat domains 1 -2.08675
STAP2 signal transducing adaptor family member 2 -2.0827
TACC3 transforming, acidic coiled-coil containing protein 3 -2.08235
CDCA3 cell division cycle associated 3 -2.07895
DCLRE1B DNA cross-link repair 1B -2.0788
SCGB1D1 secretoglobin, family 1D, member 1 -2.07682
DEF8 differentially expressed in FDCP 8 homolog (mouse) -2.0729
SPRR1A small proline-rich protein 1A -2.0678
RNF139 ring finger protein 139 -2.0652
FANCG Fanconi anemia, complementation group G -2.065
ORC6 origin recognition complex, subunit 6 -2.06395
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.06355
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.05405
LINS1 lines homolog 1 -2.0502
VDAC3 voltage-dependent anion channel 3 -2.04953
CCDC25 coiled-coil domain containing 25 -2.04295
ATRIP ATR interacting protein -2.04152
NEMP1 nuclear envelope integral membrane protein 1 -2.03725
HSPA2 heat shock 70kDa protein 2 -2.03635
MCM4 minichromosome maintenance complex component 4 -2.03499
UBAC1 UBA domain containing 1 -2.03445
CLN3 ceroid-lipofuscinosis, neuronal 3 -2.0338
IGFBP6 insulin-like growth factor binding protein 6 -2.03345
FAM131A family with sequence similarity 131, member A -2.03295
BMP2 bone morphogenetic protein 2 -2.03175
NR3C2 nuclear receptor subfamily 3, group C, member 2 -2.0314
CASP8AP2 caspase 8 associated protein 2 -2.0262
TSPAN14 tetraspanin 14 -2.02175
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -2.02045
GSTM5 glutathione S-transferase mu 5 -2.011
FAM124B family with sequence similarity 124B -2.00765
ISYNA1 inositol-3-phosphate synthase 1 -2.0062
DHFR dihydrofolate reductase -2.00537
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -2.0053
TRAIP TRAF interacting protein -2.002