CRCGN017_MCF10A.WT.HP_24H:J08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxytetracycline.hcl 33.27 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

149 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 6.1703
PHGDH phosphoglycerate dehydrogenase 5.1051
PYCR1 pyrroline-5-carboxylate reductase 1 4.9425
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 4.01225
GARS1 glycyl-tRNA synthetase 1 3.9792
AARS1 alanyl-tRNA synthetase 1 3.96215
PSAT1 phosphoserine aminotransferase 1 3.78055
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 3.6435
XPOT exportin, tRNA 3.6115
ASNS asparagine synthetase (glutamine-hydrolyzing) 3.4835
GSTM2 glutathione S-transferase mu 2 (muscle) 3.38672
FBXO7 F-box protein 7 3.0995
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.0956
EPRS1 glutamyl-prolyl-tRNA synthetase 1 2.86678
BUD31 BUD31 homolog (S. cerevisiae) 2.8573
ATF4 activating transcription factor 4 2.8335
GCC1 GRIP and coiled-coil domain containing 1 2.8244
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.79555
LOXL1 lysyl oxidase-like 1 2.6887
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.6733
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.6432
TWF2 twinfilin actin binding protein 2 2.61065
CARS1 cysteinyl-tRNA synthetase 1 2.60435
IFT88 intraflagellar transport 88 2.5698
DNTT DNA nucleotidylexotransferase 2.5328
NUP205 nucleoporin 205kDa 2.5149
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.50647
NUP133 nucleoporin 133kDa 2.49375
GSTT1 glutathione S-transferase theta 1 2.44665
ERP29 endoplasmic reticulum protein 29 2.4448
MARS1 methionyl-tRNA synthetase 1 2.37953
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.3256
CGREF1 cell growth regulator with EF-hand domain 1 2.32255
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 2.30055
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 2.30035
RBBP8 retinoblastoma binding protein 8 2.2996
NUCB2 nucleobindin 2 2.29665
RAD54L2 RAD54-like 2 (S. cerevisiae) 2.26915
NCOA6 nuclear receptor coactivator 6 2.2676
TRMT5 tRNA methyltransferase 5 2.26295
DHDDS dehydrodolichyl diphosphate synthase 2.2526
GFUS GDP-L-fucose synthase 2.24365
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.2321
MYO5C myosin VC 2.22595
TMEM160 transmembrane protein 160 2.2139
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.20515
TRIB3 tribbles pseudokinase 3 2.20265
NARS1 asparaginyl-tRNA synthetase 1 2.1918
COG5 component of oligomeric golgi complex 5 2.17685
GSTK1 glutathione S-transferase kappa 1 2.17145
PLD2 phospholipase D2 2.1635
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.1612
TNRC6B trinucleotide repeat containing 6B 2.1574
IARS1 isoleucyl-tRNA synthetase 1 2.1498
ZWILCH zwilch kinetochore protein 2.13445
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.1309
MCRS1 microspherule protein 1 2.1175
CYREN cell cycle regulator of NHEJ 2.10665
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.0834
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 2.0634
SLC31A1 solute carrier family 31 (copper transporter), member 1 2.05885
PRB4 proline-rich protein BstNI subfamily 4 2.04885
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.0467
GRB10 growth factor receptor-bound protein 10 2.04528
MPST mercaptopyruvate sulfurtransferase 2.02905
SLC35F6 solute carrier family 35, member F6 2.0276
MRPL30 mitochondrial ribosomal protein L30 2.02495
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.02335

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -7.64535
S100A8 S100 calcium binding protein A8 -6.06875
SLC25A46 solute carrier family 25, member 46 -5.1884
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.1803
KIF20A kinesin family member 20A -5.03105
PUF60 poly-U binding splicing factor 60KDa -5.0
HMG20B high mobility group 20B -4.9763
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.5246
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -4.48755
SGK1 serum/glucocorticoid regulated kinase 1 -4.1771
BASP1 brain abundant, membrane attached signal protein 1 -3.67805
TUBA4A tubulin, alpha 4a -3.39475
DCK deoxycytidine kinase -3.19545
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -3.11213
ARID4B AT rich interactive domain 4B (RBP1-like) -3.03855
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.9926
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.87832
INSIG1 insulin induced gene 1 -2.84093
MSMO1 methylsterol monooxygenase 1 -2.76355
GTF2B general transcription factor IIB -2.6459
TYRP1 tyrosinase-related protein 1 -2.63155
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.62855
GDF15 growth differentiation factor 15 -2.5674
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -2.54315
FEM1C fem-1 homolog c (C. elegans) -2.51095
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -2.4401
EGLN1 egl-9 family hypoxia-inducible factor 1 -2.4253
TLCD3A TLC domain containing 3A -2.40445
MFSD12 major facilitator superfamily domain containing 12 -2.38955
CASP8AP2 caspase 8 associated protein 2 -2.36735
NPTX1 neuronal pentraxin I -2.3654
TRIM21 tripartite motif containing 21 -2.36305
EPPK1 epiplakin 1 -2.3494
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.3459
RRAGB Ras-related GTP binding B -2.30305
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) -2.2928
ICE1 interactor of little elongation complex ELL subunit 1 -2.2919
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -2.28222
EMP2 epithelial membrane protein 2 -2.25335
CLEC16A C-type lectin domain family 16, member A -2.25175
GRAMD2B GRAM domain containing 2B -2.24885
LIFR leukemia inhibitory factor receptor alpha -2.23685
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.2265
MARCKSL1 MARCKS-like 1 -2.22425
FZD6 frizzled class receptor 6 -2.2028
CCL17 chemokine (C-C motif) ligand 17 -2.18585
ANKRD26 ankyrin repeat domain 26 -2.18105
RAB33A RAB33A, member RAS oncogene family -2.18
ZNF267 zinc finger protein 267 -2.17215
BTN2A1 butyrophilin, subfamily 2, member A1 -2.16852
ATP7A ATPase, Cu++ transporting, alpha polypeptide -2.16663
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.16145
SPDL1 spindle apparatus coiled-coil protein 1 -2.159
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.1489
GCC2 GRIP and coiled-coil domain containing 2 -2.1472
ARID4A AT rich interactive domain 4A (RBP1-like) -2.14045
MCOLN3 mucolipin 3 -2.13815
RGS18 regulator of G-protein signaling 18 -2.1358
OSTM1 osteopetrosis associated transmembrane protein 1 -2.1324
LORICRIN loricrin cornified envelope precursor protein -2.1282
JAG2 jagged 2 -2.11468
AADAC arylacetamide deacetylase -2.1009
CCN3 cellular communication network factor 3 -2.08875
POF1B premature ovarian failure, 1B -2.08725
LCE2B late cornified envelope 2B -2.0757
PDE2A phosphodiesterase 2A, cGMP-stimulated -2.0706
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.06623
GSPT2 G1 to S phase transition 2 -2.0609
TPGS1 tubulin polyglutamylase complex subunit 1 -2.0586
KRT14 keratin 14, type I -2.0582
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough -2.0523
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 -2.042
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -2.03395
DHCR24 24-dehydrocholesterol reductase -2.0319
PIGK phosphatidylinositol glycan anchor biosynthesis, class K -2.0316
SCYL3 SCY1-like 3 (S. cerevisiae) -2.03148
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -2.02975
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) -2.01895
CCNL1 cyclin L1 -2.01735
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.0103
MSTN myostatin -2.0102