CRCGN017_MCF10A.WT.HP_24H:J09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxytetracycline.hcl 11.09 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 4.99967
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.779
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.48325
PRR7 proline rich 7 (synaptic) 4.30625
FGFR4 fibroblast growth factor receptor 4 4.2906
WFS1 Wolfram syndrome 1 (wolframin) 3.74495
GPER1 G protein-coupled estrogen receptor 1 3.7443
KDM5A lysine (K)-specific demethylase 5A 3.3279
ANO10 anoctamin 10 3.29205
METRN meteorin, glial cell differentiation regulator 3.01615
NOSIP nitric oxide synthase interacting protein 2.67775
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.65785
CNRIP1 cannabinoid receptor interacting protein 1 2.5368
WIF1 WNT inhibitory factor 1 2.39965
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.37975
PLSCR1 phospholipid scramblase 1 2.24222
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 2.2293
ZBTB35 zinc finger and BTB domain containing 35 2.09955
CCNF cyclin F 2.0864
CARTPT CART prepropeptide 2.05815
FKBPL FK506 binding protein like 2.04435
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2.02885
ZNF148 zinc finger protein 148 2.02688

decreased expression

Symbol Name Standardized Value
SGK1 serum/glucocorticoid regulated kinase 1 -6.3176
KRT14 keratin 14, type I -5.0708
DERA deoxyribose-phosphate aldolase (putative) -5.0
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -4.96325
OXA1L oxidase (cytochrome c) assembly 1-like -4.7247
PRPF4 pre-mRNA processing factor 4 -4.45257
CTNND1 catenin (cadherin-associated protein), delta 1 -3.58735
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.5124
SMC1A structural maintenance of chromosomes 1A -2.94613
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.7644
UBA1 ubiquitin-like modifier activating enzyme 1 -2.59415
MSN moesin -2.5922
ACAA1 acetyl-CoA acyltransferase 1 -2.50785
PUDP pseudouridine 5'-phosphatase -2.39615
FOS FBJ murine osteosarcoma viral oncogene homolog -2.29315
SPRED2 sprouty-related, EVH1 domain containing 2 -2.20445
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 -2.19245
ZFYVE16 zinc finger, FYVE domain containing 16 -2.17635
KDM5C lysine (K)-specific demethylase 5C -2.17415
NANOS3 nanos homolog 3 (Drosophila) -2.16855
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -2.0628
PLS3 plastin 3 -2.04795
NRXN2 neurexin 2 -2.04292
NPAS2 neuronal PAS domain protein 2 -2.01905
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.01195
WASHC4 WASH complex subunit 4 -2.00435