CRCGN017_MCF10A.WT.HP_24H:J10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caprolactam 99.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

21 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.2666
E2F2 E2F transcription factor 2 4.6357
SESN1 sestrin 1 3.7088
ACAA1 acetyl-CoA acyltransferase 1 3.18455
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 2.89653
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.8692
EVL Enah/Vasp-like 2.7914
MSRA methionine sulfoxide reductase A 2.3923
ZMIZ1 zinc finger, MIZ-type containing 1 2.2338
ITPKB inositol-trisphosphate 3-kinase B 2.1124
CNRIP1 cannabinoid receptor interacting protein 1 2.06765

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -5.0
HSPA8 heat shock 70kDa protein 8 -4.77025
C2CD5 C2 calcium-dependent domain containing 5 -4.7448
NPDC1 neural proliferation, differentiation and control, 1 -4.46425
KRT14 keratin 14, type I -4.2891
MSN moesin -2.6037
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.4802
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.4279
SNX7 sorting nexin 7 -2.38165
NUP88 nucleoporin 88kDa -2.31415