CRCGN017_MCF10A.WT.HP_24H:J12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description caprolactam 11.09 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

81 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RBM6 RNA binding motif protein 6 5.60825
E2F2 E2F transcription factor 2 5.57855
CCDC92 coiled-coil domain containing 92 5.1479
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 5.01615
EPHB2 EPH receptor B2 4.75447
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.7386
FGFR4 fibroblast growth factor receptor 4 4.53675
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 4.1907
WIF1 WNT inhibitory factor 1 3.99115
TBX2 T-box 2 3.86208
TMEM50A transmembrane protein 50A 3.7063
ABHD6 abhydrolase domain containing 6 3.67683
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 2.61325
CCNF cyclin F 2.58582
NOSIP nitric oxide synthase interacting protein 2.5543
PRKCQ protein kinase C, theta 2.5444
HOXB9 homeobox B9 2.49
KANK2 KN motif and ankyrin repeat domains 2 2.48077
HSPB2 heat shock 27kDa protein 2 2.413
GDF2 growth differentiation factor 2 2.4087
REEP2 receptor accessory protein 2 2.402
MORN1 MORN repeat containing 1 2.3949
AGR2 anterior gradient 2 2.39165
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.36225
FUZ fuzzy planar cell polarity protein 2.3447
PLD2 phospholipase D2 2.3393
HOXC8 homeobox C8 2.32355
RBMX RNA binding motif protein, X-linked 2.2843
RAB40C RAB40C, member RAS oncogene family 2.27675
SH3BP1 SH3-domain binding protein 1 2.2697
ARHGAP10 Rho GTPase activating protein 10 2.2666
YJU2B YJU2 splicing factor homolog B 2.2454
DUX4 double homeobox 4 2.236
POMT2 protein-O-mannosyltransferase 2 2.21455
SAMD14 sterile alpha motif domain containing 14 2.1814
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.1782
PDCD1 programmed cell death 1 2.16185
KRT33A keratin 33A, type I 2.15385
CPNE7 copine VII 2.15075
FKBP3 FK506 binding protein 3, 25kDa 2.13665
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.132
CNRIP1 cannabinoid receptor interacting protein 1 2.12415
CARHSP1 calcium regulated heat stable protein 1, 24kDa 2.0902
MYL5 myosin, light chain 5, regulatory 2.08725
ZNF205 zinc finger protein 205 2.0593
FANCC Fanconi anemia, complementation group C 2.048
SLURP1 secreted LY6/PLAUR domain containing 1 2.031
CLDN15 claudin 15 2.0169
SCT secretin 2.0103
ADGRB1 adhesion G protein-coupled receptor B1 2.00825

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.07495
FASTKD5 FAST kinase domains 5 -4.70385
NPDC1 neural proliferation, differentiation and control, 1 -4.67915
TM9SF3 transmembrane 9 superfamily member 3 -4.67355
PCCB propionyl CoA carboxylase, beta polypeptide -4.5518
BAG3 BCL2-associated athanogene 3 -4.41945
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.0564
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.74755
STAT1 signal transducer and activator of transcription 1, 91kDa -3.21031
ACAA1 acetyl-CoA acyltransferase 1 -2.81435
KRT14 keratin 14, type I -2.80825
RBM15B RNA binding motif protein 15B -2.74925
ANXA10 annexin A10 -2.6998
FBXO21 F-box protein 21 -2.63915
WASHC4 WASH complex subunit 4 -2.55655
GCC1 GRIP and coiled-coil domain containing 1 -2.44475
TMEM230 transmembrane protein 230 -2.4398
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -2.41775
PFN1 profilin 1 -2.3351
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 -2.2203
SP140L SP140 nuclear body protein-like -2.18395
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -2.16385
KLHL3 kelch-like family member 3 -2.1201
GCAT glycine C-acetyltransferase -2.11643
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.0838
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.0788
VCPKMT valosin containing protein lysine (K) methyltransferase -2.07265
HHEX hematopoietically expressed homeobox -2.06418
ATG101 autophagy related 101 -2.05205
NAP1L3 nucleosome assembly protein 1-like 3 -2.0286
KLHL2 kelch-like family member 2 -2.0231