CRCGN017_MCF10A.WT.HP_24H:J14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

70 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KLHL21 kelch-like family member 21 5.1615
HMOX1 heme oxygenase 1 4.6927
WIF1 WNT inhibitory factor 1 4.63765
UBQLN2 ubiquilin 2 4.3132
RAB11FIP2 RAB11 family interacting protein 2 (class I) 4.1999
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.06485
STAP2 signal transducing adaptor family member 2 3.37415
AAMDC adipogenesis associated, Mth938 domain containing 2.95205
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.95095
ADRB2 adrenoceptor beta 2, surface 2.94955
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.8712
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 2.8587
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.74135
CALML4 calmodulin-like 4 2.43253
RHOT1 ras homolog family member T1 2.371
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 2.36335
ACE2 angiotensin I converting enzyme 2 2.34845
OLFML2B olfactomedin-like 2B 2.3423
H2AC25 H2A clustered histone 25 2.3359
MCUR1 mitochondrial calcium uniporter regulator 1 2.32195
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 2.3102
GSTZ1 glutathione S-transferase zeta 1 2.30165
ZNF185 zinc finger protein 185 (LIM domain) 2.2416
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 2.2025
MPPE1 metallophosphoesterase 1 2.18463
BLVRB biliverdin reductase B 2.1753
PKN1 protein kinase N1 2.16792
UNC119B unc-119 homolog B (C. elegans) 2.11345
TMEM168 transmembrane protein 168 2.10945
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 2.08965
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 2.0834
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 2.06468
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.0297
FAM3A family with sequence similarity 3, member A 2.0275
CSNK1A1 casein kinase 1, alpha 1 2.02522
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 2.0224
KLF10 Kruppel-like factor 10 2.00455
COQ8A coenzyme Q8A 2.002

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -10.0
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.8282
DNM1L dynamin 1-like -4.6995
CCNB1 cyclin B1 -4.5638
PMM2 phosphomannomutase 2 -4.15725
VAT1 vesicle amine transport 1 -3.6096
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.593
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.474
NVL nuclear VCP-like -3.02615
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.90505
ACAA1 acetyl-CoA acyltransferase 1 -2.8836
CAPRIN2 caprin family member 2 -2.76725
NGRN neugrin, neurite outgrowth associated -2.7261
DPF3 D4, zinc and double PHD fingers, family 3 -2.39175
SNX7 sorting nexin 7 -2.378
KIF18A kinesin family member 18A -2.3466
BICD1 bicaudal D homolog 1 (Drosophila) -2.34057
AK6 adenylate kinase 6 -2.31155
SRFBP1 serum response factor binding protein 1 -2.1462
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) -2.123
AMIGO2 adhesion molecule with Ig-like domain 2 -2.1045
RPAP3 RNA polymerase II associated protein 3 -2.1041
THBS2 thrombospondin 2 -2.1
TTK TTK protein kinase -2.08505
LRRC32 leucine rich repeat containing 32 -2.08265
EPCAM epithelial cell adhesion molecule -2.0611
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -2.05884
FLT4 fms-related tyrosine kinase 4 -2.05015
PKP2 plakophilin 2 -2.0404
ASB9 ankyrin repeat and SOCS box containing 9 -2.03635
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 -2.0235
DPYSL3 dihydropyrimidinase-like 3 -2.01958