CRCGN017_MCF10A.WT.HP_24H:J15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AKT1 v-akt murine thymoma viral oncogene homolog 1 5.464
STAP2 signal transducing adaptor family member 2 5.2925
CCNA1 cyclin A1 5.072
SNAP25 synaptosomal-associated protein, 25kDa 5.0467
SPAG4 sperm associated antigen 4 4.69495
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.44755
WIF1 WNT inhibitory factor 1 3.8748
KDM5A lysine (K)-specific demethylase 5A 3.52017
MINDY1 MINDY lysine 48 deubiquitinase 1 2.83285
STMN2 stathmin 2 2.6806
FAT2 FAT atypical cadherin 2 2.2794
BAHCC1 BAH domain and coiled-coil containing 1 2.1948
ALDOC aldolase C, fructose-bisphosphate 2.0518

decreased expression

Symbol Name Standardized Value
COG2 component of oligomeric golgi complex 2 -4.9174
CAB39 calcium binding protein 39 -4.4831
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.40637
ADI1 acireductone dioxygenase 1 -4.3559
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -4.33705
GLRX glutaredoxin (thioltransferase) -3.88973
DYNLT3 dynein, light chain, Tctex-type 3 -3.88155
SMNDC1 survival motor neuron domain containing 1 -3.15885
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.05947
RGS2 regulator of G-protein signaling 2 -2.71565
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.62477
GDF15 growth differentiation factor 15 -2.57575
MSN moesin -2.4557
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.37902
COTL1 coactosin-like F-actin binding protein 1 -2.35765
ANKRD10 ankyrin repeat domain 10 -2.1385
BPHL biphenyl hydrolase-like (serine hydrolase) -2.0981