CRCGN017_MCF10A.WT.HP_24H:J17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p,p'-dichlorodiphenyl sulfone 33.6 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 5.4764
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.51285
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.21975
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.64585
NOSIP nitric oxide synthase interacting protein 2.5873
SESN1 sestrin 1 2.2633
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.2315
VKORC1 vitamin K epoxide reductase complex, subunit 1 2.1854
CTDNEP1 CTD nuclear envelope phosphatase 1 2.0161

decreased expression

Symbol Name Standardized Value
PUF60 poly-U binding splicing factor 60KDa -10.0
ACOT9 acyl-CoA thioesterase 9 -5.87025
CCNB1 cyclin B1 -4.88405
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.7703
SCRIB scribbled planar cell polarity protein -4.1619
C1QBP complement component 1, q subcomponent binding protein -2.9895
ACAA1 acetyl-CoA acyltransferase 1 -2.9482
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.51613
ANKRD10 ankyrin repeat domain 10 -2.4256
GSDMD gasdermin D -2.42145
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.4096
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) -2.3905
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 -2.38995
BOP1 block of proliferation 1 -2.38882
GPA33 glycoprotein A33 (transmembrane) -2.36615
RAPSN receptor-associated protein of the synapse -2.35575
SNX7 sorting nexin 7 -2.3343
HGH1 HGH1 homolog (S. cerevisiae) -2.30267
ITGA9 integrin, alpha 9 -2.2705
KLK14 kallikrein-related peptidase 14 -2.23755
ZNF7 zinc finger protein 7 -2.22845
MEFV Mediterranean fever -2.226
EFR3B EFR3 homolog B (S. cerevisiae) -2.2099
AGTR1 angiotensin II receptor, type 1 -2.20005
DGAT1 diacylglycerol O-acyltransferase 1 -2.18245
BPHL biphenyl hydrolase-like (serine hydrolase) -2.18055
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 -2.1798
TLX1 T-cell leukemia homeobox 1 -2.1696
ZNF623 zinc finger protein 623 -2.1669
TBX19 T-box 19 -2.12175
TUBAL3 tubulin, alpha-like 3 -2.09365
HSPA12A heat shock 70kDa protein 12A -2.0931
MYL7 myosin, light chain 7, regulatory -2.0788
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -2.07335
HSF1 heat shock transcription factor 1 -2.07177
DCHS2 dachsous cadherin-related 2 -2.0669
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 -2.064
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D -2.04505
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 -2.03863
GTF2IRD2B GTF2I repeat domain containing 2B -2.02915
HYAL4 hyaluronoglucosaminidase 4 -2.02295
RPAIN RPA interacting protein -2.019