CRCGN017_MCF10A.WT.HP_24H:J18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p,p'-dichlorodiphenyl sulfone 11.2 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EPHB2 EPH receptor B2 8.40135
ACAA1 acetyl-CoA acyltransferase 1 6.1924
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.4422
UGDH UDP-glucose 6-dehydrogenase 4.7836
OLFML2B olfactomedin-like 2B 4.0316
ZBTB35 zinc finger and BTB domain containing 35 3.6454
CNRIP1 cannabinoid receptor interacting protein 1 3.5944
CXXC1 CXXC finger protein 1 3.3772
ELP3 elongator acetyltransferase complex subunit 3 2.8222
ACOT8 acyl-CoA thioesterase 8 2.704
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.6989
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.5726
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 2.3293
MRPL15 mitochondrial ribosomal protein L15 2.3233
KIFBP kinesin family binding protein 2.2831
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 2.2565
PLSCR4 phospholipid scramblase 4 2.2096
TNS3 tensin 3 2.199
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.183
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.1398
ABHD10 abhydrolase domain containing 10 2.1284
PTH1R parathyroid hormone 1 receptor 2.1284
CARM1 coactivator-associated arginine methyltransferase 1 2.086
ZNF443 zinc finger protein 443 2.0496

decreased expression

Symbol Name Standardized Value
DERA deoxyribose-phosphate aldolase (putative) -10.0
HSPA8 heat shock 70kDa protein 8 -9.95103
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -7.7229
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.2907
KRT14 keratin 14, type I -3.2504
PCNT pericentrin -3.1568
CD83 CD83 molecule -2.9779
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.95245
MSN moesin -2.8784
TRIM58 tripartite motif containing 58 -2.792
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.6064
CHAMP1 chromosome alignment maintaining phosphoprotein 1 -2.5471
SRFBP1 serum response factor binding protein 1 -2.5206
LOC105379278 uncharacterized LOC105379278 -2.4868
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -2.4666
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -2.41855
TDRD12 tudor domain containing 12 -2.4168
NCAPD2 non-SMC condensin I complex, subunit D2 -2.4112
GADD45B growth arrest and DNA-damage-inducible, beta -2.3692
PDCD10 programmed cell death 10 -2.3227
WNT5A wingless-type MMTV integration site family, member 5A -2.31885
CRLF1 cytokine receptor-like factor 1 -2.3119
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.2918
FFAR2 free fatty acid receptor 2 -2.2793
SERGEF secretion regulating guanine nucleotide exchange factor -2.2755
FOXF2 forkhead box F2 -2.242
CORO1A coronin, actin binding protein, 1A -2.2351
OSTF1 osteoclast stimulating factor 1 -2.2059
DLL3 delta-like 3 (Drosophila) -2.1821
ZDHHC7 zinc finger, DHHC-type containing 7 -2.1808
HSPA1A heat shock 70kDa protein 1A -2.1698
NBEA neurobeachin -2.1607
SETX senataxin -2.1569
BEX4 brain expressed, X-linked 4 -2.1311
TSPYL2 TSPY-like 2 -2.1295
TAC4 tachykinin 4 (hemokinin) -2.1264
RASA4B RAS p21 protein activator 4B -2.1261
BEX2 brain expressed X-linked 2 -2.1226
CCDC186 coiled-coil domain containing 186 -2.1153
ZNF514 zinc finger protein 514 -2.1119
XK X-linked Kx blood group -2.1062
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -2.0956
IGFBP7 insulin-like growth factor binding protein 7 -2.0914
NKX2-1 NK2 homeobox 1 -2.08565
LMO3 LIM domain only 3 (rhombotin-like 2) -2.0804
SLCO4C1 solute carrier organic anion transporter family, member 4C1 -2.068
HHAT hedgehog acyltransferase -2.0663
ITPKB inositol-trisphosphate 3-kinase B -2.0496
PLCB4 phospholipase C, beta 4 -2.04485
SMAP1 small ArfGAP 1 -2.0344
NSUN5 NOP2/Sun domain family, member 5 -2.03405
GPR19 G protein-coupled receptor 19 -2.0216
LOC122539214 Zinc finger protein LOC122539214 -2.0168
KLHL29 kelch-like family member 29 -2.0153